What are the main differences in how someone processes glucose from the diet vs gluconeogenesis?
Paul Jaminet, a seriously smart cookie and charming guy, writes we need a certain number of grams of glucose a day and can create it through gluconeogenesis in protein. He advocates eating less than your body needs so you are still activating the gluconeogenesis pathway.
Low carbers and circadian Krusers:
Help me understand your argument better. What is not clear to me are how eating 100g of starch a day in a the context of a high fat diet would be more deleterious than creating the glucose from protein. The high fat content would lower the blood glucose spikes.
Does gluconeogensis create more/less igf-1 or insulin?
Lets assume the person in question ingesting the "safe starches" or keto-ic gluconeogenesis diet is not insulin resistant.
I would guess that gluconeogenesis might have a slower onset vs the sudden injestion of sugars that can spike with ingested carbs being processed at one time.
Inquiring minds want to know.
asked byThinnerStrength (2204)
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on August 17, 2012
at 10:13 PM
In addition to what Drs Kruse and Jaminet said, I think an important distinction is that gluconeogenesis is regulated by internal feedback mechanisms. Safe starches are regulated by who puts the food on our plate and how big of a portion it is.
on August 17, 2012
at 11:50 PM
There are big differences between eating the sugar and having your body make it, such as similar to what Diane notes; the body is much more adept in knowing where and when the glucose is needed. The difference also depends on the precursor used; far better to use glycerol from fat, lactate, and ketones themselves than amino acids, that need hardly be used at all, if properly adapted to my diet. Most important is the effect on hormones such as insulin and leptin that glucose will raise that in turn has a major adverse impact on repair and the longevity phenotype exemplified by calorie restriction. I address this very issue in my next blog post summarizing the safe starch debate by posing 4 questions including the above, that I answer. This should go up tonight or tomorrow morning. Thanks for the question.
on August 18, 2012
at 03:13 AM
Does gluconeogenesis create more/less igf-1 or insulin?
NB: The arrow of causality is in the other direction.
Where gluconeogenesis = GN,
promotes GN: glucagon, growth hormone
inhibits GN: insulin, IGF-1
Remember, 3 ways to increase blood glucose: exogenously (eating carbs), glycogenolysis (breaking down glycogen stored in liver and muscle) and GN (synthesising glucose from proteins, glycerol and lactic acid)
The rate of glucose produced via GN can never match that of exogenous intake and only briefly matches that of glycogenolysis. Consequently, the effect on insulin is minor.