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B vitamin supplementation

Answered on August 19, 2014
Created September 11, 2012 at 8:06 PM

If I take methyl b12 and folate, will it deplete my b6, b2 and the others?

Should I try to take them all?

Trying to lower my homocysteine levels.

I do have sort of bloodshot eyes which is b2 related, so maybe I shouldn't take folate and b12 without the others. Should I go with http://www.iherb.com/Thorne-Research-Methyl-Guard-Plus-90-Veggie-Caps/33646

I originally bought individual supplements of folate, b12 but maybe I should return those?

Or do the methylated versions somehow not deplete the other b vitamins?

What do you think?

A2c38be4c54c91a15071f82f14cac0b3

(12682)

on September 11, 2012
at 11:26 PM

Ahh you're welcome. Seems like a lot of B12 though, with both supps together. You'll probably pee out most of it. Just don't want your money to end up in a toilet.

Ba09704971e33481f5716c4790648966

(1794)

on September 11, 2012
at 11:10 PM

Really good answer, thanks a lot. I think I'll try both the methyl guard and the individual supplements. I'm taking a natural folate btw. Thanks again.

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A2c38be4c54c91a15071f82f14cac0b3

(12682)

on September 11, 2012
at 10:57 PM

Since vitamin B6 has a role in methylating (detoxifying) homocysteine, supplementing B12 and folate (since they can also perform this role) will likely spare B6 in the body. And because the conversion of pyridoxine (the form of B6 commonly found in food) to pyridoxal (the biologically active form) may use B2, B2 may ultimately be spared a bit as well (but maybe not, more on that shortly).

So I believe vitamin B12 and folate will spare B6 and B12 will spare B2. This is speculative on my part, but it appears largely supported by the scientific literature. However, I think folate supplementation may hurt B2 status and here's why:

Vitamin B2 appears to be an cofactor for Methylenetetrahydrofolate reductase, or MTHFR (I enjoy that acronym). MTHFR is necessary for the conversion of folate to a form that can mathylate homocysteine. Essentially, vitamin B2 may be used to support the detoxification of homocysteine by folate, lowering B2.

So to summarize: I think B12 will be beneficial to B2 and B6 status. I also think folate will help B6 status, but it might hurt B2 status, I don't know for sure. Also, synthetic folate is considered by some to be a risky supplement, better gotten from food. I might skip the supplement and look for folate from good food sources like leafy greens and liver, since they also come rich in B2.

Some references:

"Riboflavin (vitamin B-2) and health"

"Biochemical assessment of the nutritional status of vitamin B6 in the human"

"Folic Acid: Nutritional Biochemistry, Molecular Biology, and Role in Disease Processes"

Ba09704971e33481f5716c4790648966

(1794)

on September 11, 2012
at 11:10 PM

Really good answer, thanks a lot. I think I'll try both the methyl guard and the individual supplements. I'm taking a natural folate btw. Thanks again.

A2c38be4c54c91a15071f82f14cac0b3

(12682)

on September 11, 2012
at 11:26 PM

Ahh you're welcome. Seems like a lot of B12 though, with both supps together. You'll probably pee out most of it. Just don't want your money to end up in a toilet.

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