1

votes

Genotype for the MTHFR C677T: What does this mean? (PLAIN ENGLISH PLEASE)

Answered on August 19, 2014
Created August 22, 2013 at 7:15 PM

Pasted below is the lab result for some genetic testing I had done.

  1. What the heck does this mean (in plain english please), and
  2. Could it have any potential relevance to someone who seems to be having issues with amines/salicylates?

Here's the result:

"This patient has the normal or wild-type genotype for the MTHFR C677T (C/C) polymorphism and is homozygous for MTHFR A1298C (C/C). The A1298C C/C genotype results in significantly reduced activity of MTHFR, potentially leading to diminished production of L- methylfolate, the active form of folate. Reduced levels of L-methylfolate lead to decreased production of neurotransmitters, reduced conversion of homocysteine to methionine, and reduced s-adenosylmethionine (SAMe) concentrations. CNS neurochemical deficiency, along with buildup of homocysteine and decreased availability of methyl groups from SAMe, may increase an individual???s risk for developing cardiovascular disease. Additionally, this may predispose an individual to certain psychiatric disorders and/or memory and attention deficits. Patients who are homozyogous for the MTHFR A1298C polymorphism should consider supplementation with the active L-methylfolate in combination with vitamin B12 (methylcobalamin). Increased homocysteine levels may reflect other conditions (B- vitamin deficiencies, renal disease, etc.), which should be evaluated prior to initiating supplementation."

Many thanks,

Mike

543a65b3004bf5a51974fbdd60d666bb

(4493)

on September 17, 2013
at 10:52 PM

this article seems to have some good info on the MTHFR C677T Mutation, may be worth a read, MTHFR C677T Mutation: Basic Protocol

7fc82eebafd44badc73c520f44660150

(3275)

on August 22, 2013
at 10:21 PM

thank you. and yes, this particular topic hurts my head (very complicated) :-)

7fc82eebafd44badc73c520f44660150

(3275)

on August 22, 2013
at 08:12 PM

He said take L- methylfolate supplements. He's not at all familiar with any food intolerance issues like histamine, amines, salicylates so he's certainly not going to be able to add value on the inter-relationship between the two.

Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

6 Answers

best answer

1
Bcb2f5436d11467e89123680c046b858

(1356)

on August 22, 2013
at 10:17 PM

I and several of my family members have MTHFR mutations. They can predispose you to blood clots, cardiovascular problems, and neuro-psychiatric problems. It's a complicated issue and I find it quite difficult to understand. The short version of treatment is to avoid folic acid and supplement with methylfolate. B12 is often needed as well, but not all kinds of B12 are optimal.

Here are some resources:

MTHFR.net

http://geneticgenie.org/

7fc82eebafd44badc73c520f44660150

(3275)

on August 22, 2013
at 10:21 PM

thank you. and yes, this particular topic hurts my head (very complicated) :-)

0
7fc82eebafd44badc73c520f44660150

on January 12, 2014
at 03:56 PM

Since posting this question, I've done an enormous amount of research on MTHFR.

I created two public evernote folders of my web clippings, in case anyone finds it useful, here it is:

https://www.evernote.com/pub/pcguys/mthfr_general

https://www.evernote.com/pub/pcguys/mthfr_me

0
9f8e26e7d8a764e067efcb02516d85e2

on December 19, 2013
at 11:50 AM

Another resource www.nutrahacker.com

0
534871cea2fa853559ba41d4df9206d2

on December 17, 2013
at 05:49 PM

what means this sentence(MTHFR C677T is wild type-normal)?

,

0
543a65b3004bf5a51974fbdd60d666bb

(4493)

on September 03, 2013
at 06:08 AM

On your point 2. i have not come across any info on mthfr & amines/salicylates,
but i have seen plenty of mentions of histamine and mthfr/methylation (i noticed you have histamine as a tag) .

From what i can glean;
if you are undermethylating (for some reason*), then histamine levels are likely high (above normal).
& if you are overmethylating (for some reason*), then histamine levels are likely low (below normal).

*& i guess that one of the reasons could be gene related.

...that's all i got...(i agree, it's very complicated)

543a65b3004bf5a51974fbdd60d666bb

(4493)

on September 17, 2013
at 10:52 PM

this article seems to have some good info on the MTHFR C677T Mutation, may be worth a read, MTHFR C677T Mutation: Basic Protocol

0
336c383a3c4d28652d7ab888c79108a3

on August 22, 2013
at 07:58 PM

What did your doctor say??

7fc82eebafd44badc73c520f44660150

(3275)

on August 22, 2013
at 08:12 PM

He said take L- methylfolate supplements. He's not at all familiar with any food intolerance issues like histamine, amines, salicylates so he's certainly not going to be able to add value on the inter-relationship between the two.

Answer Question


Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!