Pasted below is the lab result for some genetic testing I had done.
- What the heck does this mean (in plain english please), and
- Could it have any potential relevance to someone who seems to be having issues with amines/salicylates?
Here's the result:
"This patient has the normal or wild-type genotype for the MTHFR C677T (C/C) polymorphism and is homozygous for MTHFR A1298C (C/C). The A1298C C/C genotype results in significantly reduced activity of MTHFR, potentially leading to diminished production of L- methylfolate, the active form of folate. Reduced levels of L-methylfolate lead to decreased production of neurotransmitters, reduced conversion of homocysteine to methionine, and reduced s-adenosylmethionine (SAMe) concentrations. CNS neurochemical deficiency, along with buildup of homocysteine and decreased availability of methyl groups from SAMe, may increase an individual???s risk for developing cardiovascular disease. Additionally, this may predispose an individual to certain psychiatric disorders and/or memory and attention deficits. Patients who are homozyogous for the MTHFR A1298C polymorphism should consider supplementation with the active L-methylfolate in combination with vitamin B12 (methylcobalamin). Increased homocysteine levels may reflect other conditions (B- vitamin deficiencies, renal disease, etc.), which should be evaluated prior to initiating supplementation."
asked byCaveMan_Mike (3275)
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on August 22, 2013
at 10:17 PM
I and several of my family members have MTHFR mutations. They can predispose you to blood clots, cardiovascular problems, and neuro-psychiatric problems. It's a complicated issue and I find it quite difficult to understand. The short version of treatment is to avoid folic acid and supplement with methylfolate. B12 is often needed as well, but not all kinds of B12 are optimal.
Here are some resources:
on January 12, 2014
at 03:56 PM
on December 19, 2013
at 11:50 AM
Another resource www.nutrahacker.com
on December 17, 2013
at 05:49 PM
what means this sentence(MTHFR C677T is wild type-normal)?,
on September 03, 2013
at 06:08 AM
On your point 2. i have not come across any info on mthfr & amines/salicylates,
but i have seen plenty of mentions of histamine and mthfr/methylation (i noticed you have histamine as a tag) .
From what i can glean;
if you are undermethylating (for some reason*), then histamine levels are likely high (above normal).
& if you are overmethylating (for some reason*), then histamine levels are likely low (below normal).
*& i guess that one of the reasons could be gene related.
...that's all i got...(i agree, it's very complicated)