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a link between high protein consumption and growth hormone to cancer.

Commented on February 13, 2014
Created February 11, 2014 at 9:09 PM

saw this documentary the other day which spoke about the benfits of fasting. they said fasting reduces growth hormone levels and also let the body the chance to "fix" itself. they said that high growth hormone increases the risk of getting cancer. and there is a direct relationship between protien consumption to growth hormone. the more protein you get from your diet the more growth hormone you have and the result is higher risk to get cancer.

I wonder if someone has any objections about this.

Cf08ad26759fdd206a2c9f9385080a57

(995)

on February 13, 2014
at 01:06 AM

By weight, the diet works out to about 3/4 plant foods, 1/4 animal foods. By calories, it works out to about 600 carb calories, primarily from starches; around 300 protein calories; and fats supply a majority (50-60%) of daily calories.

75 grams is right around the sweet spot of 1g/kg protein requirements for nitrogen balance, in the middle of where peak muscle/protein intake is reached at 150g. After 150g, protein becomes excessive.

I've seen a few people on here with 200g+ daily intakes, but most aim for more conservative numbers.

Be157308a0438e382b88d9db4c12ab30

on February 12, 2014
at 07:42 PM

The evidence is not saying to stop eating protein, protein is an absolutely essential nutrient and must be consumed in the human diet. What is being said is that the amount of protein that is eaten should be moderated and that excess protein can be harmful for the above stated reasons. Continue to eat protein, you need it, but don't assume that just because eating a 24 ounce Sirloin steak is perfectly Paleo it will also be healthy. Many things that are technically Paleo are unhealthy in large doses. Just because you see other people doing something, doesn't mean you should blindly follow.

70b7242f51987c5d442128ead283b8f9

(0)

on February 12, 2014
at 07:18 PM

in this case, im probably missing something. as far as i know (not much) about paleo, it is based on protein and fat. so how is it goes along with these facts? paleo people consume alot of protein dont they?

De1095b2ba29c1035f00428cbfe3cc7c

(777)

on February 12, 2014
at 06:50 PM

Thanks for the links guys, good stuff!

Be157308a0438e382b88d9db4c12ab30

on February 12, 2014
at 01:04 AM

Maybe pastoral societies were cancer free, maybe not. The point is that they often died from reasons unknown and their lifespans were not necessarily longer (often they were shorter). Ancient civilizations didn't exactly get CT scans or go to oncologists when they got cancer symptoms, often they just died and natural causes were assumed. Many also died from disease and other third-world maladies that we don't have to deal with in our modern industrialized society. You can't get cancer at 60 if you die from malaria at 23.

Be157308a0438e382b88d9db4c12ab30

on February 12, 2014
at 12:58 AM

Their might be healthy in spite of a high protein diet, not because of a high protein diet. Epidimiological observations prove nothing. Assuming you're neither Inuit or Masai living in the Arctic or the jungles of Africa, respectively, then you would be mistaken to believe adapting a single aspect of their diet (high-protein) would necessarily lead to better health. Jeanne Calment, the oldest human to ever live, was a smoker. By your logic, people should take up smoking because a certain person who lived a long time did so as well, in spite of all the scientific evidence to the contrary.

56c28e3654d4dd8a8abdb2c1f525202e

(1822)

on February 12, 2014
at 12:42 AM

au contraire, I am interested in cancer outcomes for those who neither smoke nor drink because that population resembles me more than the general US population. I agree that I have not been selected as much as the Inuit have. On the other hand there are multiple data points of hunter gatherers or pastoral societies being largely cancer free at different latitudes. The Masai for example. I will be able to see the papers tomorrow at work, but I am guessing it is not the proteins alone.

Cf08ad26759fdd206a2c9f9385080a57

(995)

on February 11, 2014
at 11:58 PM

In the second link they mention excess methionine could counter the benefits. Fascinating stuff http://www.youtube.com/watch?v=t9PcwVOn3N4

Be157308a0438e382b88d9db4c12ab30

on February 11, 2014
at 11:37 PM

Don't go by epidimiological observations, these studies are never reliable indicators as there are many other factors involved such as cold temperatures, physical exertion, highly selective environment where only the very well adapted survived, accuracy of birth certificates, no smoking and alcohol, etc. This is the same reason why Ancel Keys's lipid hypothesis was flawed; it only looked at epidimiological observations from certain countries he saw fit his curve. True science uses controlled experimentation to derive conclusions.

Be157308a0438e382b88d9db4c12ab30

on February 11, 2014
at 11:07 PM

Good stuff. I really liked that second link, quite an interesting read. Thanks.

Cf08ad26759fdd206a2c9f9385080a57

(995)

on February 11, 2014
at 10:41 PM

Also http://www.sciencedirect.com/science/article/pii/0047637483900143 (referenced in http://materiais.dbio.uevora.pt/BD/Crescimento/Mitohormesis.pdf) I couldn't find a study on superoxide dismutase in relation to human diets. I'd be very curious to see that.

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4 Answers

0
70b7242f51987c5d442128ead283b8f9

on February 12, 2014
at 07:15 PM

in this case, im probably missing something. as far as i know (not much) about paleo, it is based on protein and fat. so how is it goes along with these facts? paleo people consume alot of protein dont they?

0
3fad84c6627ed9a26e05427d58e061ab

on February 12, 2014
at 03:10 PM

The only thing I can add to this is a counter I heard to this argument was that the studies that show protein causing this did not isolate the effect of protein and were also with a high processed carb diet and there was not consideration of confounding factors caused by the inflammation a high carb diet would cause.

0
56c28e3654d4dd8a8abdb2c1f525202e

(1822)

on February 11, 2014
at 11:16 PM

the question that comes to mind is why traditional Inuit, at 25% of calories, used to not get cancer.

Be157308a0438e382b88d9db4c12ab30

on February 11, 2014
at 11:37 PM

Don't go by epidimiological observations, these studies are never reliable indicators as there are many other factors involved such as cold temperatures, physical exertion, highly selective environment where only the very well adapted survived, accuracy of birth certificates, no smoking and alcohol, etc. This is the same reason why Ancel Keys's lipid hypothesis was flawed; it only looked at epidimiological observations from certain countries he saw fit his curve. True science uses controlled experimentation to derive conclusions.

0
Be157308a0438e382b88d9db4c12ab30

on February 11, 2014
at 09:59 PM

No objections from me on this issue. This is a topic that has been discussed multiple times. Nevertheless, it doesn't hurt to bring to light some scientific data relevant to this discussion.

Effect of Protein Intake on IGF-1: http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2008.00417.x/full

Insulin and IGF-1 signaling pathways and effects on longevity: http://ajpendo.physiology.org/content/285/5/E1064

Reduced Insulin and IGF-1 receptor activity lowers body weight and increases lifespan: http://press.endocrine.org/doi/abs/10.1210/en.2003-0374

This information supports your contention that protein raises levels of hormones (specifically insulin and insulin-like growth factor 1 or IGF-1) and in so doing promotes aging and carcinogenesis. Intracellularly, the mechanisms involved would be PI3K, Akt and mTORC1, which are activated by insulin, IGF-1 and other growth factors, amino acids and glucose.

70b7242f51987c5d442128ead283b8f9

(0)

on February 12, 2014
at 07:18 PM

in this case, im probably missing something. as far as i know (not much) about paleo, it is based on protein and fat. so how is it goes along with these facts? paleo people consume alot of protein dont they?

Cf08ad26759fdd206a2c9f9385080a57

(995)

on February 11, 2014
at 10:41 PM

Also http://www.sciencedirect.com/science/article/pii/0047637483900143 (referenced in http://materiais.dbio.uevora.pt/BD/Crescimento/Mitohormesis.pdf) I couldn't find a study on superoxide dismutase in relation to human diets. I'd be very curious to see that.

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