I never had any issues with histamine until approx. 3 years ago when I started eating high-fat diet. Since then I am extremely sensitive. Anyone noticed the same thing?
Found this research that seems to support my theory:
Google for "Nutrient-induced inflammation in the intestine" and click the first link.
There is increasing evidence linking gut local inflammatory events with the intake of nutrients. Our recent studies, using the conscious lymph fistula rat model, demonstrate that fat absorption activates the intestinal mucosal mast cells. This is accompanied by a dramatic increase in the lymphatic release of mast cell mediators including histamine, rat mucosal mast cell protease II (RMCPII), as well as the lipid mediator prostaglandin D2 (PGD2). Clinical studies suggest that increased consumption of animal fat may play a role in the pathogenesis of inflammatory bowel disease. This impact of dietary fat may not be restricted to the gut but may extend to the whole body. nThere is evidence liking a high-fat diet-induced metabolic syndrome, with a low-grade chronic inflammatory state. In this review, we hope to convince the readers that fat absorption can have far reaching physiological and pathophysiological consequences.
This seems to discuss the research above (had no time to read it yet though):
That Paleo Guy website: google for Nutrient-induced inflammation in the intestine. and click the second link.
This scares the shit out of me:
It is entirely possible that the chronic consumption of a high-fat diet can compromise the integrity of the intestinal barrier by disrupting the balance of epithelial injury and restitution, due to inappropriate and exaggerated mucosal immune responses that can potentially result in increased entry of pathogens or microorganisms into the body from the intestinal lumen. The integrity of the tight junction is compromised by the chronic consumption of a high-fat diet.
As much as That Paleo Guy may argue with the article, I feel like a living proof that high fat diet causes at least bad histamine intolerance.
asked bylib8 (0)
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on June 01, 2018
at 08:31 AM
You inspired me to look for the high fat diet and histamine intolerance I sat for days searching through a lot of information.
I have read all possible articles and pages about it. This trail and your question allowed me to combine many facts. I'm trying to recover my health.
Thanks to your suggestion I combined my problems with high estrogen level> high histamine> probably gene mutation MTHFR and Mast Cell Activation Syndrome > problems with cortisol / stress hormone> thyroid problems.
I'm 2 years on high-fat diet and discovered my basic basis of the problem and the mechanism of action that drives my illness!!! I can not believe it!!! because I know how many people it brings to health benefits..... and I am 1% who do not!!!! :( All my diseases, hormonal disorders began to "come out" on a high-fat diet
Do you use any medications regarding this histamine intolerance?
Do you use an anti-histamine diet? how does it look like?
on January 19, 2015
at 11:13 AM
which kind of food makes you feeling sick and what are your symptoms?
I'm sensitive to histamine as well and I'm able to take a dietary supplement called Daosin. It makes it possible for me to eat what I like even histamine rich food. I couldn't eat a certain kind of cheese and mushrooms!
You can talk with your allergist about it, maybe it helps ;)