13

votes

what is a leaky gut?

Answered on September 12, 2014
Created January 08, 2012 at 12:02 PM

So I see this on here all the time about what "causes" a leaky gut or how to "fix" a leaky gut, but what IS a leaky gut? What are the symptoms (in layman speak) of a leaky gut? How do you know you have a leaky gut?

695d450f25e1e5f4eba82c615206cc5a

(189)

on January 09, 2012
at 04:58 PM

that was helpful for someone who had no idea what it was to begin with! Thank you.

742ff8ba4ff55e84593ede14ac1c3cab

(3536)

on January 08, 2012
at 10:00 PM

Don't underestimate the powers of astrophysics.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 09:58 PM

@Kamal, he has to be one stubborn guy.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 09:22 PM

No seriously, how is he still alive? He gets no physical activity, has a disease which has killed everyone else on earth who's had it decades before their 70th birthdays, almost certainly doesn't eat paleo, etc etc. Maybe he's so smart that he's convinced his cells to keep doing their thing.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 09:20 PM

He's sooooooo cool. Also, how the heck is he still alive? I should ask Paul Jaminet, since he used to be an astrophysicist and they probably all hang out together.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 09:13 PM

I'm a big Hawking fan.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 08:25 PM

Today is Stephen Hawking's birthday!! Happy Birthday, big guy! (figuratively speaking) He wasn't able to attend his bash because of health issues :( .....http://www.nydailynews.com/news/world/stephen-hawking-misses-70th-birthday-celebration-due-unknown-health-issue-article-1.1002530?localLinksEnabled=false

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 08:22 PM

@Kamal, tee hee!

100fd85230060e754fc13394eee6d6f1

(18706)

on January 08, 2012
at 08:21 PM

I've encountered many brilliant people, too, and none of them communicated remotely like Quilt. I don't need things dumbed down. I can understand what he is writing the way it is, and I can see it for what it is. It's not that there is no truth to what he says, it's that there isn't any evidence of reasoning.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 08:21 PM

And he does share Quilt's desire to tie things together on a grander scale..."All of my life, I have been fascinated by the big questions that face us, and have tried to find scientific answers to them. Perhaps that is why I have sold more books on physics than Madonna has on sex."

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 08:19 PM

Stephen Hawking is pretty smart. Has trouble with typing, but pretty good at communicating nonetheless. He is an exceptional case, of course.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 08:09 PM

@Ambimorph, I wasn't speaking to his credentials, which are valid, but to his practice and research and the manner in which he is choosing to live his life. Simply because of living this long, I've encountered many brilliant people and they pretty much all communicated like Quilt. To write a book, they usually need a "translator" to dumb it down for people like me. Ad lib communication is usually at their level of expertise, as I said, which means they need understanding or highly educated spouses. :-

100fd85230060e754fc13394eee6d6f1

(18706)

on January 08, 2012
at 07:59 PM

It never ceases to amaze me how many people are impressed by credentials and fancy words strung together, no matter what those words actually say. To say that this is speaking at his level of expertise is not complimentary, Nance.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 07:58 PM

@Nance-- If I was a private practice neurosurgeon, I sure as heck wouldn't be concerned with monetizing my website. Up in these parts, that job gets you $700,000 a year, and for good reason. That being said, I fully expect Dr. Kruse to buy paleohackers a round at AHS12. Drinking is great for loosening tense relations, right? (Or is it the other way around?)

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on January 08, 2012
at 07:44 PM

damn, must be a lot of tired arms and shoulders 'round these parts from carrying water...

Aead76beb5fc7b762a6b4ddc234f6051

(15239)

on January 08, 2012
at 07:28 PM

if anyone has been wondering if its possible to throw out ones cervical spin from laughing so hard, im here to tell you that i can indeed happen.

3a567c1637db69f1455ce35e78201a2c

(1054)

on January 08, 2012
at 07:07 PM

@shari Glad you are insulted because it seems as if you have difficulty doing any research at all to see if the Quilt knows what he is talking about. Obviously you have chosen not to start or finish the Leaky Gut RX or the Leptin Reset RX...because if you did you would have learned how to do brain surgery on yourself without a scalpel.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 06:53 PM

And, as you know, boiling blood may be good to eat but it's not good for my health so I will now take a deep breath and turn away.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 06:51 PM

@Shari, just for the record the Quilt is Dr Jack Kruse and is a high-level expert on leptin resistance among MANY other things. He could be making even more money than he makes as a surgeon but he chose to build a free web site chocked full of advice you'd have to pay big money for. Makes my blood boil to see people diss him.

C8b2136ef95ba6aac211825ff38cc0e9

(971)

on January 08, 2012
at 06:39 PM

*sigh*... anyway, I plan to look at the blog.

98bf2ca7f8778c79cd3f6c962011cfdc

(24286)

on January 08, 2012
at 06:38 PM

Oh please. He did some half-assed cut and paste job from God-knows-where and couldn't be bothered to format it so it was in ANY WAY readable or decipherable AND didn't even answer the question that was asked. Yes that is worthy of complaint. It's insulting. Who the hell knows if he knows what he's talking about because who the hell can read it?????

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 06:18 PM

You guys got bona fide free advice from an expert and you complained that he didn't phrase it as if he didn't know what he was talking about. Most people speak at the level of their expertise, you know.

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on January 08, 2012
at 06:12 PM

and anything that lowers alpha MSH in the brain is associated with a leaky gut.

A942dbc90fe12f7f90744a68f9f223e2

(249)

on January 08, 2012
at 06:11 PM

I read as far as the 2nd sentence of the 2nd paragraph, then I passed out :-(

C8b2136ef95ba6aac211825ff38cc0e9

(971)

on January 08, 2012
at 05:48 PM

Thanks for the link...

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on January 08, 2012
at 05:34 PM

I'm in church trying to read this and I just asked dear lord Jesus to take me now. Like right now.

0dbd7154d909b97fe774d1655754f195

(16131)

on January 08, 2012
at 05:34 PM

Look at you, using paragraphs and reasonable sentence structure! Plus one ........

98bf2ca7f8778c79cd3f6c962011cfdc

(24286)

on January 08, 2012
at 05:33 PM

I thought the question was "what IS a leaky gut". This, whatever this is, doesn't appear to address the original question.

0dbd7154d909b97fe774d1655754f195

(16131)

on January 08, 2012
at 05:32 PM

I don't give a shit about gut health anymore because I can't uncross my eyes from trying to read that. CURED!

Cc7381bd787721575ea9198048132adb

(5541)

on January 08, 2012
at 05:30 PM

Very simple........

Aead76beb5fc7b762a6b4ddc234f6051

(15239)

on January 08, 2012
at 05:15 PM

i have a migraine now.

C8b2136ef95ba6aac211825ff38cc0e9

(971)

on January 08, 2012
at 05:11 PM

...as far as the supps I think.

C8b2136ef95ba6aac211825ff38cc0e9

(971)

on January 08, 2012
at 05:08 PM

It's Jack Kruse prescription.

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on January 08, 2012
at 05:02 PM

What's wrong with you people? This is definitely the accessible, mainstream advice that will win people to our cause. I understood it all, perfectly.

1f8384be58052b6b96f476e475abdc74

(2231)

on January 08, 2012
at 04:52 PM

so thats wat 50 supplements?

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 04:24 PM

Thanks for the tips at the end, Quilt! I have disc degenerative disease (although it seems better now due to bone broths) but I never heard of using epsom salt baths for it. I'll give it a try!

D07a525f9021f8d72bf6aaa52893c795

(1011)

on January 08, 2012
at 03:42 PM

A layman's answer was requested! I recommend Chris Kresser's blog for an excellent explanation - as well as the importance.

07ca188c8dac3a17f629dd87198d2098

(7970)

on January 08, 2012
at 03:39 PM

It looks like someone's biology textbook had a bad LSD trip and vomited all over paleohacks.

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on January 08, 2012
at 03:21 PM

There is more........but I cant write any more.

B0fe7b5a9a197cd293978150cbd9055f

(8938)

on January 08, 2012
at 02:58 PM

If you have acne, theres a BIG chance you have it.

E34fbfa1bca9ae970c9c7313bf9de9f8

(1436)

on January 08, 2012
at 02:38 PM

it's also known as "intestinal permeability".

1096aa84d006fe967128ffbd37e8070e

(1002)

on January 08, 2012
at 01:47 PM

I'm just now starting to hear about Ray Peat. Doesn't he talk about leaky gut being the root of all problems?

B0fe7b5a9a197cd293978150cbd9055f

(8938)

on January 08, 2012
at 12:48 PM

http://jackkruse.com/the-leaky-gut-prescription/

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8 Answers

9
D07a525f9021f8d72bf6aaa52893c795

(1011)

on January 08, 2012
at 04:01 PM

Layman's version..

As a consequence of autoimmune attack on the intestinal lining - in particular the small intestine - the contents can leak into the bloodstream. This means that autoimmune disease and inflammation may then occur anywhere in the body, manifesting as a host of conditions, such as allergies, arthritis etc.

The classic autoimmune initiation is by glutens, a family of proteins which are found in cereal grains - and most especially problematic being wheat glutens.

Without going into the mechanisms, one can say this happens because elements of these protein types are so similar to proteins in our own body tissues that they can "trick" our immune system into attacking our own cells - hence the term autoimmune disease. Could it be so simple that autoimmune disease is caused by eating wheat? Well - yes! "Wheat Belly" - Dr William Davis's recent book is a an excellent approach to this topic, as well as being easy to read from the layman's perspective.

IMHO - this is in no small part what makes the paleo diet so spectacularly successful - elimination of grains.

0dbd7154d909b97fe774d1655754f195

(16131)

on January 08, 2012
at 05:34 PM

Look at you, using paragraphs and reasonable sentence structure! Plus one ........

2
Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on January 08, 2012
at 03:20 PM

  1. Very simple??????..Eat a dairy free version of the paleolithic diet and add a vegetables that have polyphenols in them and green leafy vegetables. It would be advisable to make them all organic to avoid pesticides that could cause a secondary neolithic disease like diabetes from atrazine toxicity.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 09:13 PM

I'm a big Hawking fan.

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on January 08, 2012
at 03:21 PM

There is more........but I cant write any more.

0dbd7154d909b97fe774d1655754f195

(16131)

on January 08, 2012
at 05:32 PM

I don't give a shit about gut health anymore because I can't uncross my eyes from trying to read that. CURED!

98bf2ca7f8778c79cd3f6c962011cfdc

(24286)

on January 08, 2012
at 05:33 PM

I thought the question was "what IS a leaky gut". This, whatever this is, doesn't appear to address the original question.

Aead76beb5fc7b762a6b4ddc234f6051

(15239)

on January 08, 2012
at 05:15 PM

i have a migraine now.

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on January 08, 2012
at 07:44 PM

damn, must be a lot of tired arms and shoulders 'round these parts from carrying water...

1f8384be58052b6b96f476e475abdc74

(2231)

on January 08, 2012
at 04:52 PM

so thats wat 50 supplements?

A942dbc90fe12f7f90744a68f9f223e2

(249)

on January 08, 2012
at 06:11 PM

I read as far as the 2nd sentence of the 2nd paragraph, then I passed out :-(

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 07:58 PM

@Nance-- If I was a private practice neurosurgeon, I sure as heck wouldn't be concerned with monetizing my website. Up in these parts, that job gets you $700,000 a year, and for good reason. That being said, I fully expect Dr. Kruse to buy paleohackers a round at AHS12. Drinking is great for loosening tense relations, right? (Or is it the other way around?)

C8b2136ef95ba6aac211825ff38cc0e9

(971)

on January 08, 2012
at 05:11 PM

...as far as the supps I think.

3a567c1637db69f1455ce35e78201a2c

(1054)

on January 08, 2012
at 07:07 PM

@shari Glad you are insulted because it seems as if you have difficulty doing any research at all to see if the Quilt knows what he is talking about. Obviously you have chosen not to start or finish the Leaky Gut RX or the Leptin Reset RX...because if you did you would have learned how to do brain surgery on yourself without a scalpel.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 08:22 PM

@Kamal, tee hee!

C8b2136ef95ba6aac211825ff38cc0e9

(971)

on January 08, 2012
at 05:08 PM

It's Jack Kruse prescription.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 08:09 PM

@Ambimorph, I wasn't speaking to his credentials, which are valid, but to his practice and research and the manner in which he is choosing to live his life. Simply because of living this long, I've encountered many brilliant people and they pretty much all communicated like Quilt. To write a book, they usually need a "translator" to dumb it down for people like me. Ad lib communication is usually at their level of expertise, as I said, which means they need understanding or highly educated spouses. :-

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on January 08, 2012
at 06:12 PM

and anything that lowers alpha MSH in the brain is associated with a leaky gut.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 09:58 PM

@Kamal, he has to be one stubborn guy.

742ff8ba4ff55e84593ede14ac1c3cab

(3536)

on January 08, 2012
at 10:00 PM

Don't underestimate the powers of astrophysics.

Aead76beb5fc7b762a6b4ddc234f6051

(15239)

on January 08, 2012
at 07:28 PM

if anyone has been wondering if its possible to throw out ones cervical spin from laughing so hard, im here to tell you that i can indeed happen.

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on January 08, 2012
at 05:34 PM

I'm in church trying to read this and I just asked dear lord Jesus to take me now. Like right now.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 08:25 PM

Today is Stephen Hawking's birthday!! Happy Birthday, big guy! (figuratively speaking) He wasn't able to attend his bash because of health issues :( .....http://www.nydailynews.com/news/world/stephen-hawking-misses-70th-birthday-celebration-due-unknown-health-issue-article-1.1002530?localLinksEnabled=false

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 06:53 PM

And, as you know, boiling blood may be good to eat but it's not good for my health so I will now take a deep breath and turn away.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 04:24 PM

Thanks for the tips at the end, Quilt! I have disc degenerative disease (although it seems better now due to bone broths) but I never heard of using epsom salt baths for it. I'll give it a try!

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on January 08, 2012
at 05:02 PM

What's wrong with you people? This is definitely the accessible, mainstream advice that will win people to our cause. I understood it all, perfectly.

100fd85230060e754fc13394eee6d6f1

(18706)

on January 08, 2012
at 07:59 PM

It never ceases to amaze me how many people are impressed by credentials and fancy words strung together, no matter what those words actually say. To say that this is speaking at his level of expertise is not complimentary, Nance.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 09:20 PM

He's sooooooo cool. Also, how the heck is he still alive? I should ask Paul Jaminet, since he used to be an astrophysicist and they probably all hang out together.

C8b2136ef95ba6aac211825ff38cc0e9

(971)

on January 08, 2012
at 06:39 PM

*sigh*... anyway, I plan to look at the blog.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 06:18 PM

You guys got bona fide free advice from an expert and you complained that he didn't phrase it as if he didn't know what he was talking about. Most people speak at the level of their expertise, you know.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 08:21 PM

And he does share Quilt's desire to tie things together on a grander scale..."All of my life, I have been fascinated by the big questions that face us, and have tried to find scientific answers to them. Perhaps that is why I have sold more books on physics than Madonna has on sex."

D07a525f9021f8d72bf6aaa52893c795

(1011)

on January 08, 2012
at 03:42 PM

A layman's answer was requested! I recommend Chris Kresser's blog for an excellent explanation - as well as the importance.

98bf2ca7f8778c79cd3f6c962011cfdc

(24286)

on January 08, 2012
at 06:38 PM

Oh please. He did some half-assed cut and paste job from God-knows-where and couldn't be bothered to format it so it was in ANY WAY readable or decipherable AND didn't even answer the question that was asked. Yes that is worthy of complaint. It's insulting. Who the hell knows if he knows what he's talking about because who the hell can read it?????

07ca188c8dac3a17f629dd87198d2098

(7970)

on January 08, 2012
at 03:39 PM

It looks like someone's biology textbook had a bad LSD trip and vomited all over paleohacks.

Cc7381bd787721575ea9198048132adb

(5541)

on January 08, 2012
at 05:30 PM

Very simple........

100fd85230060e754fc13394eee6d6f1

(18706)

on January 08, 2012
at 08:21 PM

I've encountered many brilliant people, too, and none of them communicated remotely like Quilt. I don't need things dumbed down. I can understand what he is writing the way it is, and I can see it for what it is. It's not that there is no truth to what he says, it's that there isn't any evidence of reasoning.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 09:22 PM

No seriously, how is he still alive? He gets no physical activity, has a disease which has killed everyone else on earth who's had it decades before their 70th birthdays, almost certainly doesn't eat paleo, etc etc. Maybe he's so smart that he's convinced his cells to keep doing their thing.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on January 08, 2012
at 06:51 PM

@Shari, just for the record the Quilt is Dr Jack Kruse and is a high-level expert on leptin resistance among MANY other things. He could be making even more money than he makes as a surgeon but he chose to build a free web site chocked full of advice you'd have to pay big money for. Makes my blood boil to see people diss him.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on January 08, 2012
at 08:19 PM

Stephen Hawking is pretty smart. Has trouble with typing, but pretty good at communicating nonetheless. He is an exceptional case, of course.

2
8949bf87b0e0aefcad10f29975e4fa2b

(8989)

on January 08, 2012
at 02:45 PM

Check out the GAPS diet to "fix" your gut if you have problems.

2
072fd69647b0e765bb4b11532569f16d

(3717)

on January 08, 2012
at 02:34 PM

695d450f25e1e5f4eba82c615206cc5a

(189)

on January 09, 2012
at 04:58 PM

that was helpful for someone who had no idea what it was to begin with! Thank you.

1
B6400137b7a50279de74a24a2e08ae7f

on September 14, 2012
at 10:38 PM

There are lots of potential causes of leaky gut, including but not limited to gluten, protease inhibitors like trypsin, and anything that affects zonulin (which modulates the tight junctions in the intestinal wall). But as for what to do about it vis-a-vis paleo, the most important thing to remember is that food content should never enter directly into the bloodstream and now it is, so your immune system will be reacting to stuff that never gave you issues pre-leaky gut. The 2nd thing to remember is that leaky gut often goes hand-in-hand with gut dysbiosis, which is an imbalance of "bad" bacteria. This means that starches & sugars might feed this imbalance, which is why you see such a strict control on both (and going to extreme measures with specific types of carbs in SCD and GAPS diets) in Paleo spinoffs targeting autoimmune disease & leaky gut.

Here's my blog comparing how 4 Paleo spinoffs (Terry Wahl's, Robb Wolf's, SCD, GAPS) address leaky gut syndrome: http://blog.healclick.com/evolving-paleo-diet-for-leaky-gut-syndrome/

1
D10ca8d11301c2f4993ac2279ce4b930

(5242)

on January 09, 2012
at 05:13 PM

A leaky gut is when lactulose/mannitol is able to escape from the gut undigested directly into the blood stream. This indicates that the tight junction in the gut aren't tight enough to act as an impermeable barrier. You know if you have one by taking a lactulose/mannitol test. If you have a leaky gut, all sorts of things can be wrong so the symptoms are incredibly numerous. It doesn't hurt to test especially if you have autoimmune issues.

0
Cf4576cbcc44fc7f2294135609bce9e5

on January 08, 2012
at 05:29 PM

various bacterial infectious agents of disease routinely encountered by man such as salmonella and the vibrio trigger an immune response where massive amounts of fluid leak out as an aid to fight of the invaders. this has an advantage for survival and in the past must have been indispensable for survival. unfortunately for some food can aggravate the same pathways triggering a similar responses where the gut permeability is ounce again changed and the gut leaks fluid where in this case molecules of a given size can now freely leak into the lymph collection system and find access to the blood immune system where they activate the immune system to fight circulating food molecules instead of bacteria. its seems we are not so perfect in design and have a built in flaw. the good news is if we eat a very old diet, one that man ate for the majority of mankind's immune system developmental history, we can avoid foods that lead to leaky gut. most mainstream physicians ignore the syndrome because they have no training to deal with the issue. its interesting to note that both salmonella and vibrio are both Foodborne illness. As a young man dairy was an irritant for me and wheat gluten had yet to become a problem. modern man will also consume irritants other than food that irritate the bowl such as aspirin or alcohol and even large amounts of harmless sugar can lead to bowel irritation. age is not a factor in gut leak issues. more importantly it is gut history thats most important. i hope everybody can understand the layman's language i carefully selected. its not effective to communicate knowledge in a foreign tongue.

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