just stumbled across an interesting review about crohn's disease and it makes sense. http://www.nature.com/mi/journal/v1/n1s/full/mi200848a.html
Essentially they say that the gut lining needs antimicrobial proteins in order to contain the gut flora and prevent it from "trespassing" into the body. Those substances are mainly a-defensin and b-defensin which are secreted by Paneth-cells.
Those "natural antibiotics" seem to be able to selectively knock out certain bacteria strains in order to keep a healthy gut population.
Now in Crohn's disease (and I guess several other conditions) there's a lack of defensins in those Paneth-cells, hence they're not able to control the gut flora any more and a secondary inflammation response is triggered as the bacteria damages the gut lining.
I know this is a tough one, but could there be a mineral/vitamin/amino acid etc. which supports defensin production? Wikipedia says defensin is a cysteine rich protein, could this be an approach? Paneth-Cells contain a lot of zinc, another idea?
btw. this might be another reason why excessive fiber is detrimental, it simply overloades the defensin system by overly feeding the bacteria.
asked byThomy (2384)
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on November 08, 2012
at 02:58 AM
Thanks for posting this. I'm really curious about what the dietary recommendations might be for improving our defensins. According to this paper, vitamin D may be beneficial:
"Vitamin D can enhance the induction of the antimicrobial peptides cathelicidin and ??-defensin"
I found a lot of information, but I think I need to read up on this topic because at this point a bit of it is over my head. Still very interesting though.