6

votes

what's the proof that lectins are gut irritants

Answered on September 12, 2014
Created October 20, 2011 at 9:21 PM

I've read descriptions by Wolf and Cordain of what lectins do in the gut, but the devil's advocate in me is just wondering whether this is "fact" or just a highly controversial theory (given that many people disagree with the no-grains thing.) Has the impact of lectins on the gut actually been scientifically proven? And if not, why not?

90bcfafd2ef73fea5398c483c593349e

(872)

on February 26, 2013
at 05:43 AM

I have to say I share your distaste for doctors, Lady_Arwen. For over a decade I was led astray by verious doctors. I remember being laughed at by a dermatologist when I brought up the subject of dietary triggers for breakouts. One doctor put me on a course of anti-biotics for so long it took me years to get my digestion back. Yet another wouldn't let me out of her office without a bunch of Viactiv calcium chews, because lord knows chocolate candy is a much better source of vitamins than vegetables could ever be...I could go on, but you get the drift, right? Our medical system is so broken.

90bcfafd2ef73fea5398c483c593349e

(872)

on February 26, 2013
at 05:32 AM

Right there with you, animaleater! I never thought my digestion would improve when I clogged up my intestines with all that terrible, terrible meat, but I was so wrong! I now have to make sure not to eat too many veggies...who'd have ever thought!

Medium avatar

(10611)

on February 26, 2013
at 02:52 AM

If you have IBS and it helps to avoid them, good for you. For those of us who don't, it doesn't really matter all that much. If eating baked beans at picnics shortens my life by 15 nanoseconds I don't really care. It's not worth giving the vegans at the picnic something to laugh at.

Medium avatar

(10611)

on February 26, 2013
at 02:41 AM

Why aren't the Japanese affected? If lectins are such a horror, these unrepentant soy-eaters should be dying at 20 instead of 85. Anyone who finds lectins frightening (in caps) should seriously examine their chicken-liver.

Medium avatar

(10611)

on February 26, 2013
at 02:37 AM

Start with population statistics first. If lectins are such evil killers, why are they eaten by the longest-lived people in the world? This is one of the most bogus of all paleo's "sky-is-falling" canards.

Medium avatar

(10611)

on February 26, 2013
at 02:31 AM

What a cynical attitude. My doctor taught me to take responsibility and fix myself.

Medium avatar

(10611)

on February 26, 2013
at 02:27 AM

Alarmism 101. What connection does a castor bean have with a kidney bean?

Medium avatar

(2417)

on March 20, 2012
at 02:48 AM

I've got some kinda IBS too. Dido on the meat thing. I can down two pounds of meat by itself with nothing to compete with it, and digests effortlessly.....and my trip to the toilet afterwards is the most normal ever.

Cf4576cbcc44fc7f2294135609bce9e5

(3125)

on December 20, 2011
at 09:53 PM

most doctors are as sick or sicker than the general population and certainly do not live any longer. they die of heart disease and diabetes just like their patients. if they were even close to being smarter than you they would not have become doctors.

F92e4ca55291c3f3096a3d4d3d854986

(11698)

on October 24, 2011
at 06:34 PM

Thanks, everyone for your comments and links. I feel that it's not just conventional doctors who failed me, but all the naturopaths and herbalists and others I consulted, some of whom advocated cutting out wheat because of the gluten, but none of whom even mentioned lectins. I mean, I've been working on a diet for IBS for 15 years and I just learned about all this 3 weeks ago. Crazy. Also all those same health professionals telling me to avoid meat products because they were "hard to digest". Turns out my body digests meat no problem!

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 02:33 AM

*haaA* I doubt it. The google scholar kicked out 15k references! I'll get to them when I have insomnia next time *wink*

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 02:31 AM

True but in defense of docs, they truly think they are helping... in their white ivory towers.

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 24, 2011
at 02:30 AM

I'm more of a synthetic organic chemist and as such my understanding of biochemistry is limited to what I'm actually doing. It certainly sounds like you have more extensive knowledge on this than I do! No, I haven't read "A Dirty Life", but I'll look into it.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 12:15 AM

Matt, Have you read 'A dirty life'? One of my favorite books on farming!

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 12:14 AM

Maj, I still want access to your hard-drive. *haaaa!*

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 12:14 AM

ROB -- VERY FRIGHTENING. These fetuses will likely have gut permeability issues extending from neonates, not a great way to start out life. All neonates have leaky gut (to absorb all of mom's milk goodies, e.g. IgM, colostrum, etc) but it is supposed seal up within a few wks. I think these lectins may pose an obstacle to regularly neonatal and ped development of gut physiology and immunity... just a guess.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 11:44 PM

Matt, Thank you in advance for your replies!! One other burning question I have: Why does HLA DQ2 bind gliadin and gluten??! They are supposed to bind pathogens, not food. Is this a quirk? Or evolved plant host defense?? What is a few autoimmune foraging animal diseases versus longevity of a plant reproductive system, no? Ra ma Ra max (at) gmail no spaces -- thanks!

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 11:41 PM

Matt, Can you email me your stuff and links?? I suck at immunology. What is your area of research? I have ImmunoBiology by Janeyway and Travers but the 3rd edition -- WAY WAY outdated and definitely not paleo... What text do you rec?? Carbs and glycoproteins are really cool. I think it is way cool too that we 'farm' the gut microbes by feeding them glycoproteins on the tips of our enterocytes. What kind of lectins other than MBL do we have? Can you give me some links?

77877f762c40637911396daa19b53094

(78467)

on October 23, 2011
at 05:53 PM

nice find. Thx.

742ff8ba4ff55e84593ede14ac1c3cab

(3536)

on October 23, 2011
at 04:35 PM

Very interesting.

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 23, 2011
at 02:58 PM

Grace, we have tons of lectins (human) in our bodies. My own PhD research deals with carbohydrates and their interactions between lectins, chemokines, and growth factors. Interesting stuff!

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:24 PM

http://www.animalbiotechnology.org/product.asp [old 2001 list of Bt toxin/lectin GMO crops]

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:13 PM

Matt -- love google scholar.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:12 PM

Matt, Maj -- we do have our own lectins like MBL (mannose binding lectin) whcih activates complement and our immune system. I guess many pathways are conserved across lifeforms including lectins... THis is very concerning because our exposures (like gluten) in the modern Big Agra age are VASTLY if not exponentially degrees higher. Hunter gatherers had exposures to gluten at zero to a few parts per million. Now the average SAD'er eats 10-15 GRAMS per day. Lectins???? Plus we make our OWN. At least with gluten, we don't self-synthesize and it doesn't have an integral role in OUR immunity

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:11 PM

Matt, Maj -- we do have our own lectins like MBL (mannose binding lectin) whcih activates complement and our immune system. I guess many pathways are conserved across lifeforms including lectins... THis is very concerning because our exposures (like gluten) in the modern Big Agra age are VASTLY if not exponentially degrees higher. Hunter gatherers had exposures to gluten at zero to a few parts per million. Now the average SAD'er eats 10-15 GRAMS per day. Lectins???? Plus we make our OWN. At least with gluten, we don't self-synthesize and it doesn't have an integral role in immunity.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:06 PM

STUNNING FIND!!! Thank you for the quotes.

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on October 22, 2011
at 07:59 PM

lol ... ... ... .

5ef574d7893bc816ec52e04139e9bc09

(6097)

on October 22, 2011
at 07:29 PM

today i learned what lectins actually do

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 22, 2011
at 05:03 PM

@majkinetor - The premise that our digestive systems should be impervious to lectins, miRNA, toxins, etc.. is not necessarily true. Humans have likely been exposed to these various things throughout evolution. They're not artifacts of a neolithic food base.

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:24 PM

Some more: http://www.ncbi.nlm.nih.gov/pubmed/15381156

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:21 PM

Here is something, I am not sure how to understand this: http://cancerres.aacrjournals.org/content/47/1/47.short

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:19 PM

On second thought, it does make sense that plant lectins are more toxic then animal lectins...

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:16 PM

As always, any input is both beneficial and harmful. You aim to improve the ratio. Its idiotic to try to omit all foods that are toxic. Its better to boost your detox power by supplying resources for liver and kidney and other helps like antioxidants, C, clay/zeolit etc.. You should know something about that, I hear that farmers use zeolith a lot to detox farm animals.

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:13 PM

Its similar to that story about miRNAs. They recently pointed out that rice contain lots of them and that they are bioactive, but I am pretty certain that once they start looking for them, scientist will find them everywhere. Healthy digestive system should be able to handle such insults without problem since they are natural and ubiquitous.

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:11 PM

No, that part is not weird. Its weird that lectins are harmful since they are ubiquitous. Is there any evidence that similar toxicity is there with animal lectins?

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 22, 2011
at 01:18 PM

And we have our own human lectins as well. It's not weird, it just a fundamental way multicellular life communicates between cells.

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 09:27 AM

http://www.sciencedirect.com/science/article/pii/S0304416502003082

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 09:22 AM

Its strange as lectins as also fundamental animal proteins.

1d9af5db8833413037be3ac48964714f

(3789)

on October 22, 2011
at 02:48 AM

First, doctors live in this modern industrial society and have trouble imagining behavior outside of cultural norms. Second, even if they could conceive of it, they know that almost no patients would give up bread and pasta anyway.

Cc7381bd787721575ea9198048132adb

(5541)

on October 22, 2011
at 12:46 AM

This answer is terrifying, because it's so true.

6714718e2245e5190017d643a7614157

on October 21, 2011
at 06:54 PM

I agree. Doctors are in business to make money. Most (not all) doctors don't care about your health, they just want to keep you alive and reduce your symptoms via medication. If everyone ate paleo and were healthy, doctors would never be able to payoff their student loans.

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 21, 2011
at 02:34 AM

Apologies if my response was a bit brusque, but there seems to be a sizable amount of info out there. Why it gets ignored, who knows.

9d43f6873107e17ca4d1a5055aa7a2ad

on October 21, 2011
at 12:54 AM

they also teach almost no nutrition in med school!

9d43f6873107e17ca4d1a5055aa7a2ad

on October 21, 2011
at 12:53 AM

most gastros just don't consider food because it's too hard to control and too hard to figure out. drugs are easier for them and more consistant.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on October 20, 2011
at 11:08 PM

Interesting find as I am researching today: http://www.biomedcentral.com/1472-6823/5/10

Medium avatar

(19469)

on October 20, 2011
at 10:59 PM

It's simple, If they told you to avoid grains, they would lose a paychec..I mean "patient."

F92e4ca55291c3f3096a3d4d3d854986

(11698)

on October 20, 2011
at 10:57 PM

Thanks. I guess I just don't understand why, since this is proven fact, no gastroenterologist has ever told me to give up grains.

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5 Answers

6
Ec7cb2a7a68655954a01f03e95be1383

on October 22, 2011
at 11:03 AM

A little overview:

Essential sugars are sugars that have specific biological functions within the body. Different types of sugars coat the surfaces of cells and help them to communicate with each other (...) Plant lectins are poisonous proteins. Ricin is a lectin made from castor beans, and a well-known poison that has been used by the KGB and terrorists in the USA that causes massive blood clotting. Lectins have a wide variety of different structures and are grouped together under the term "lectin" based on their effects on human blood. Lectins are carbohydrate-binding proteins that attach themselves to essential sugars in the human body. They are glycoproteins just like their protective counterparts. Essential sugars typically coat the surfaces of cells and help them to communicate. **Lectins bind to the essential sugars and disrupt cellular communication. When they do this, they can cause agglutination ??? that is, the blood may clump together. It is thought that plant lectins exist as defence mechanisms. Many have lethal effects on various insects and cause stomach upsets in foraging animals ??? and humans.

http://failsafediet.wordpress.com/about-food-chemical-intolerance/the-natural-toxins-in-food/essential-sugars-and-plant-lectins/

Here's an interesting paper:

Among the effects observed in the small intestine of lectin fed rodents is stripping away of the mucous coat to expose naked mucosa and overgrowth of the mucosa by abnormal bacteria and protozoa.Lectins also cause discharge of histamine from gastric mast cells, which stimulates acid secretion. So the three main pathogenic factors for peptic ulcer???acid stimulation, failure of the mucous defence layer, and abnormal bacterial proliferation (Helicobacter pylori) are all theoretically linked to lectins.

The mucus stripping effect of lectins also offers an explanation for the anecdotal finding of many allergists that a ???stone age diet,??? which eliminates most starchy foods and therefore most lectins, protects against common upper respiratory viral infections: without lectins in the throat the nasopharyngeal mucus lining would be more effective as a barrier to viruses.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115436/

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on October 22, 2011
at 07:59 PM

lol ... ... ... .

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:06 PM

STUNNING FIND!!! Thank you for the quotes.

5ef574d7893bc816ec52e04139e9bc09

(6097)

on October 22, 2011
at 07:29 PM

today i learned what lectins actually do

Medium avatar

(10611)

on February 26, 2013
at 02:27 AM

Alarmism 101. What connection does a castor bean have with a kidney bean?

4
8508fec4bae4a580d1e1b807058fee8e

on October 21, 2011
at 03:03 AM

Most doctors cannot make money unless they drug you or cut you (surgery). Think: lifetime customer value - a person that's sick the rest of their life - autoimmune, diabetes, arthritis - most modern diseases - that's an industry for so many people. Don't expect them to cure you or put you in remission unless they are Paleo-friendly! When they do give give nutritional advice (it's usually conventional wisdom or worse)!

6714718e2245e5190017d643a7614157

on October 21, 2011
at 06:54 PM

I agree. Doctors are in business to make money. Most (not all) doctors don't care about your health, they just want to keep you alive and reduce your symptoms via medication. If everyone ate paleo and were healthy, doctors would never be able to payoff their student loans.

Cc7381bd787721575ea9198048132adb

(5541)

on October 22, 2011
at 12:46 AM

This answer is terrifying, because it's so true.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 02:31 AM

True but in defense of docs, they truly think they are helping... in their white ivory towers.

Medium avatar

(10611)

on February 26, 2013
at 02:31 AM

What a cynical attitude. My doctor taught me to take responsibility and fix myself.

90bcfafd2ef73fea5398c483c593349e

(872)

on February 26, 2013
at 05:43 AM

I have to say I share your distaste for doctors, Lady_Arwen. For over a decade I was led astray by verious doctors. I remember being laughed at by a dermatologist when I brought up the subject of dietary triggers for breakouts. One doctor put me on a course of anti-biotics for so long it took me years to get my digestion back. Yet another wouldn't let me out of her office without a bunch of Viactiv calcium chews, because lord knows chocolate candy is a much better source of vitamins than vegetables could ever be...I could go on, but you get the drift, right? Our medical system is so broken.

3
32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 20, 2011
at 09:43 PM

Medium avatar

(19469)

on October 20, 2011
at 10:59 PM

It's simple, If they told you to avoid grains, they would lose a paychec..I mean "patient."

1d9af5db8833413037be3ac48964714f

(3789)

on October 22, 2011
at 02:48 AM

First, doctors live in this modern industrial society and have trouble imagining behavior outside of cultural norms. Second, even if they could conceive of it, they know that almost no patients would give up bread and pasta anyway.

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 09:27 AM

http://www.sciencedirect.com/science/article/pii/S0304416502003082

F92e4ca55291c3f3096a3d4d3d854986

(11698)

on October 20, 2011
at 10:57 PM

Thanks. I guess I just don't understand why, since this is proven fact, no gastroenterologist has ever told me to give up grains.

9d43f6873107e17ca4d1a5055aa7a2ad

on October 21, 2011
at 12:53 AM

most gastros just don't consider food because it's too hard to control and too hard to figure out. drugs are easier for them and more consistant.

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 21, 2011
at 02:34 AM

Apologies if my response was a bit brusque, but there seems to be a sizable amount of info out there. Why it gets ignored, who knows.

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:11 PM

No, that part is not weird. Its weird that lectins are harmful since they are ubiquitous. Is there any evidence that similar toxicity is there with animal lectins?

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on October 20, 2011
at 11:08 PM

Interesting find as I am researching today: http://www.biomedcentral.com/1472-6823/5/10

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:21 PM

Here is something, I am not sure how to understand this: http://cancerres.aacrjournals.org/content/47/1/47.short

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 22, 2011
at 05:03 PM

@majkinetor - The premise that our digestive systems should be impervious to lectins, miRNA, toxins, etc.. is not necessarily true. Humans have likely been exposed to these various things throughout evolution. They're not artifacts of a neolithic food base.

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:19 PM

On second thought, it does make sense that plant lectins are more toxic then animal lectins...

9d43f6873107e17ca4d1a5055aa7a2ad

on October 21, 2011
at 12:54 AM

they also teach almost no nutrition in med school!

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 09:22 AM

Its strange as lectins as also fundamental animal proteins.

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:24 PM

Some more: http://www.ncbi.nlm.nih.gov/pubmed/15381156

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:13 PM

Its similar to that story about miRNAs. They recently pointed out that rice contain lots of them and that they are bioactive, but I am pretty certain that once they start looking for them, scientist will find them everywhere. Healthy digestive system should be able to handle such insults without problem since they are natural and ubiquitous.

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 22, 2011
at 01:18 PM

And we have our own human lectins as well. It's not weird, it just a fundamental way multicellular life communicates between cells.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:13 PM

Matt -- love google scholar.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 11:41 PM

Matt, Can you email me your stuff and links?? I suck at immunology. What is your area of research? I have ImmunoBiology by Janeyway and Travers but the 3rd edition -- WAY WAY outdated and definitely not paleo... What text do you rec?? Carbs and glycoproteins are really cool. I think it is way cool too that we 'farm' the gut microbes by feeding them glycoproteins on the tips of our enterocytes. What kind of lectins other than MBL do we have? Can you give me some links?

77877f762c40637911396daa19b53094

(78467)

on October 22, 2011
at 02:16 PM

As always, any input is both beneficial and harmful. You aim to improve the ratio. Its idiotic to try to omit all foods that are toxic. Its better to boost your detox power by supplying resources for liver and kidney and other helps like antioxidants, C, clay/zeolit etc.. You should know something about that, I hear that farmers use zeolith a lot to detox farm animals.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:11 PM

Matt, Maj -- we do have our own lectins like MBL (mannose binding lectin) whcih activates complement and our immune system. I guess many pathways are conserved across lifeforms including lectins... THis is very concerning because our exposures (like gluten) in the modern Big Agra age are VASTLY if not exponentially degrees higher. Hunter gatherers had exposures to gluten at zero to a few parts per million. Now the average SAD'er eats 10-15 GRAMS per day. Lectins???? Plus we make our OWN. At least with gluten, we don't self-synthesize and it doesn't have an integral role in immunity.

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 23, 2011
at 02:58 PM

Grace, we have tons of lectins (human) in our bodies. My own PhD research deals with carbohydrates and their interactions between lectins, chemokines, and growth factors. Interesting stuff!

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 02:33 AM

*haaA* I doubt it. The google scholar kicked out 15k references! I'll get to them when I have insomnia next time *wink*

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:12 PM

Matt, Maj -- we do have our own lectins like MBL (mannose binding lectin) whcih activates complement and our immune system. I guess many pathways are conserved across lifeforms including lectins... THis is very concerning because our exposures (like gluten) in the modern Big Agra age are VASTLY if not exponentially degrees higher. Hunter gatherers had exposures to gluten at zero to a few parts per million. Now the average SAD'er eats 10-15 GRAMS per day. Lectins???? Plus we make our OWN. At least with gluten, we don't self-synthesize and it doesn't have an integral role in OUR immunity

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 11:44 PM

Matt, Thank you in advance for your replies!! One other burning question I have: Why does HLA DQ2 bind gliadin and gluten??! They are supposed to bind pathogens, not food. Is this a quirk? Or evolved plant host defense?? What is a few autoimmune foraging animal diseases versus longevity of a plant reproductive system, no? Ra ma Ra max (at) gmail no spaces -- thanks!

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 12:15 AM

Matt, Have you read 'A dirty life'? One of my favorite books on farming!

32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 24, 2011
at 02:30 AM

I'm more of a synthetic organic chemist and as such my understanding of biochemistry is limited to what I'm actually doing. It certainly sounds like you have more extensive knowledge on this than I do! No, I haven't read "A Dirty Life", but I'll look into it.

Cf4576cbcc44fc7f2294135609bce9e5

(3125)

on December 20, 2011
at 09:53 PM

most doctors are as sick or sicker than the general population and certainly do not live any longer. they die of heart disease and diabetes just like their patients. if they were even close to being smarter than you they would not have become doctors.

1
15e43e479657bd30fc279457a75974a3

on February 26, 2013
at 02:17 AM

I too want to know more about the SCIENCE behind these claims. I am very intrigued by the lectin debate and I know we ALL want the truth. I just find it hard to believe that more reserchers have not tried apply normal trails to this....very frustrating.

Medium avatar

(10611)

on February 26, 2013
at 02:37 AM

Start with population statistics first. If lectins are such evil killers, why are they eaten by the longest-lived people in the world? This is one of the most bogus of all paleo's "sky-is-falling" canards.

1
3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:23 PM

I'm so glad you posed this question -- I was wondering the SAME THING. This is an underestimated factor I believe in epidemic levels of food allergies (GMO peanut/soy/corn), ADHD, ASD, autoimmune disorders and cancer...because all are associated if not caused by intestinal permeability. I used to think it was gluten dominant phenomenon but lectins do it too if not worse (esp if genetically engineered for high expression of lectins and multiple gene copies, to attempt to prevent resistance patterns in native pests/beetles).

What do you think of sources of lectins (from GMO crops) impervious to cooking and that may even be propagated by horizontal gene transfer to our gut microbiome...?

(1) http://www.organicconsumers.org/articles/article_11361.cfm [Spilling the Beans: Unintended GMO Health Risks]

(2) http://somloquesembrem.files.wordpress.com/2010/07/arisleblanc2011.pdf

[Maternal and fetal exposure to Bt Lectin/toxin and pesticides associated to genetically modified foods in Eastern Townships of Quebec,Canada]

Abstract: Pesticides associated to genetically modified foods(PAGMF), are engineered totolerate herbicides such as glyphosate (GLYP) and gluphosinate(GLUF) o rinsecticides such as the bacterial toxin bacillus thuringiensis (Bt). The aim of this study was to evaluate thecorrelation between maternal and fetal exposure, and to determine exposure levels of GLYP and its metabolite aminomethylphosphoricacid(AMPA), GLUF and its metabolite 3-methylphosphinicopropionicacid(3-MPPA) and Cry1Ab protein(a Bt toxin) [MICROBIAL LECTIN] in East- ern Townships of Quebec, Canada. Blood of thirtyp regnantwomen(PW) and thirty-nine nonpregnant women (NPW) were studied.Serum GLYPand GLUF were detected in NPW and not detected in PW. Serum 3-MPPA and CryAb1 toxin [Bt LECTIN] were detected in PW, their fetuses and NPW. This is the first study to reveal the presence of circulating PAGMF inwomen with and without pregnancy, paving the way fora new field in reproductive toxicology including nutrition and utero-placental toxicities.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 12:14 AM

ROB -- VERY FRIGHTENING. These fetuses will likely have gut permeability issues extending from neonates, not a great way to start out life. All neonates have leaky gut (to absorb all of mom's milk goodies, e.g. IgM, colostrum, etc) but it is supposed seal up within a few wks. I think these lectins may pose an obstacle to regularly neonatal and ped development of gut physiology and immunity... just a guess.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 23, 2011
at 01:24 PM

http://www.animalbiotechnology.org/product.asp [old 2001 list of Bt toxin/lectin GMO crops]

77877f762c40637911396daa19b53094

(78467)

on October 23, 2011
at 05:53 PM

nice find. Thx.

3864f9a2af09b1b447c7963058650a34

(3703)

on October 24, 2011
at 12:14 AM

Maj, I still want access to your hard-drive. *haaaa!*

742ff8ba4ff55e84593ede14ac1c3cab

(3536)

on October 23, 2011
at 04:35 PM

Very interesting.

Medium avatar

(10611)

on February 26, 2013
at 02:41 AM

Why aren't the Japanese affected? If lectins are such a horror, these unrepentant soy-eaters should be dying at 20 instead of 85. Anyone who finds lectins frightening (in caps) should seriously examine their chicken-liver.

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