4

votes

Should everyone take this pill?

Answered on August 19, 2014
Created December 20, 2011 at 7:55 AM

I came across this article about an Rx drug being developed to relieve symptoms caused by Ceilac patients after digesting gluten.

Should we all (hypothetically) take something like this? I know I've felt better since avoiding gluten (4 months now).

http://www.celiac.com/articles/22731/1/Efficacy-Data-from-Phase-2a-Trial-of-ALV003-in-Celiac-Disease-Patients/Page1.html

24fcc21452ebe39c032be6801d6bbadd

(9812)

on December 21, 2011
at 03:07 PM

Cool, I hope they help! :)

7841848bd0c27c64353c583fb7971242

(7275)

on December 21, 2011
at 01:50 PM

Hmm, it looks like the one you linked doesn't have the betaine hydrochloride, so it wouldn't cause me the same trouble as the NOW foods super enzymes. Thanks!

7841848bd0c27c64353c583fb7971242

(7275)

on December 21, 2011
at 01:46 PM

Jules, good idea. I've tried NOW super enzymes a few times, but if I have a bout of diarrhea after I've taken them, it burns, so I'm holding off until things are more stable. It's interesting that they help you tolerate gluten: I'm guessing it helps your body break down the gliadin. I have celiac disease, so I can never eat a noticeable amount of gluten, but I would love to not have to worry about trace amounts.

24fcc21452ebe39c032be6801d6bbadd

(9812)

on December 21, 2011
at 01:18 PM

Sara, have you tried digestive enzymes? I am probably a lot less sensitive than you, but I've had good results from taking these- http://www.amazon.com/Source-Naturals-Daily-Essential-Enzymes/dp/B000GFJJSI/ref=pd_sim_hpc_2 I eat gluten willingly from time to time, and most of the time I avoid symptoms if a take a few capsules.

A968087cc1dd66d480749c02e4619ef4

(20436)

on December 21, 2011
at 12:35 PM

As is a blanket dismissal of "Big Pharma". I'm not anti doctors, medicine or even drug companies. But I am skeptical of the "benefits" of many drugs - and wary of nasty side effects. The problem is that human biochemistry is massively complicated with many unknowns. Tampering with it should only be done with extreme caution (including dietary tampering). And btw, my answer was facetious (duh!) and simply for a laugh. Its also interesting to note that the language we use can change our perception of reality...

D10ca8d11301c2f4993ac2279ce4b930

(5242)

on December 20, 2011
at 06:21 PM

a blanket dismissal of modern medicine is naive.

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 06:05 PM

Yeah, I wonder that too. I highly doubt enough research would be done on its safety and mechanisms of action before releasing it to the public, unfortunately.

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 06:05 PM

Yeah, I wonder that too. I highly doubt enough research would be done on it's safety and mechanisms of action before releasing it to the public, unfortunately.

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 06:03 PM

This is interesting and helpful. Thanks for posting it.

Cf4576cbcc44fc7f2294135609bce9e5

(3125)

on December 20, 2011
at 05:42 PM

i could not have said it better my self. seriously i dont write that eloquent

B9637ddb9a9a5c6a7306e3c804fcd21d

(3217)

on December 20, 2011
at 03:53 PM

Sara - I didn't mean to completely debunk it - I do agree that this could be a useful tool in some circumstances where you really cannot control what you eat for severe celiacs.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on December 20, 2011
at 03:43 PM

The key question might be, would such a pill retard your healing so the process took even longer. But I definitely would want the pill in your situation.

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 03:02 PM

I make my food from scratch. I don't eat processed food except for coconut oil. And yet, I would love to have a (safe) pill I could take when I go to someone's house, they try to cook gluten-free, and I want to be able to actually eat. My work also involves a lot of traveling to foreign countries for a few days to a week, and I'd love to be able to eat something other than pemmican when I'm there. I think you're being too strict here. The food paranoia I have to contend with, as a severely sensitive celiac, is disturbing, and I'd love to be a normal gluten-free person once in a while.

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 03:00 PM

I make my food from scratch. I don't eat processed food except for coconut oil. And yet, I would love to have a (safe) pill I could take for the holiday season when work requires I go to someone's house, they cook gluten-free, and I want to be able to actually eat. My work also involves a lot of traveling to foreign countries for a few days to a week, and I'd love to be able to eat something other than pemmican when I'm there. I think you're being too strict here. The food paranoia I have to contend with, as a severely sensitive celiac, is disturbing, even eating my own unprocessed food.

1321554fbe74ad09e97c6e8c354021cc

(524)

on December 20, 2011
at 01:30 PM

Thanks, Milla. I hope you understood the ironic tone of "everyone" in the title of my post. I simply meant that, since science confers that gluten is not easily digested by some, and impossible to digest by others, we might use this as evidence to support a largely gluten-free, unprocessed diet for mainstream society. I wasn't at all suggesting that we should eat gluten to our tastebuds'-content, and take this "miracle" cure as a means of easing around the issue. But I think you get me. :-) And I agree with Edward. Excellent answer.

775bc83a7c54975e77a8500e065a24c3

(814)

on December 20, 2011
at 01:16 PM

excellent answer

Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

11 Answers

10
B9637ddb9a9a5c6a7306e3c804fcd21d

(3217)

on December 20, 2011
at 12:40 PM

Before I get to the 'everyone' bit, let me mention people with severe celiac. This article, I think, is directed at people with extreme gluten intolerance that would have severe digestive issues even from trace amounts of gluten due to cross-contamination. So, you think, as its impossible to avoid, you have to take the drug? Look at this bit:

Since gluten is so common in food processing, it's almost impossible to avoid ingesting tiny amounts of gluten, even for people with celiac disease.

The key bit is 'food processing'. If you are primal/paleo, the main point is avoiding processed food. If you eat meat, vegetables, perhaps raw nuts & seeds, even dairy, from trusted sources, you will avoid gluten. Just avoid pre-packaged, pre-processed food, and you won't need to pop pills.

Now, the 'everyone' bit. So, people can continue eating gluten-containing food, as long as they take a pill to counteract the damage? That's like saying, its fine if we drink poison, as long as we drink the antidote straight after. Of course, wheat isn't arsenic, but the point still stands.

Perhaps you'll avoid the intestinal perforation from gluten, but you're still consuming a Neolithic Agent of Disease (NAD), with plenty of other negative side-effects besides the gluten content - what about the anti-nutrients in grain? And all those carbs (if you're an athlete, go bake a sweet potato.)? To add insult to injury, you're basically adding another NAD (chemicals from the medicine). Do you really need to ingest more chemicals and drugs, what with all the pollution and chemical contamination that goes on anyhow?

I hope this didn't come across as harsh, I don't mean it to, but I just found this rather absurd - not surprising though, since Big Pharma always gets out of its way to cure the symptoms without addressing the underlying cause, and allow people to continue poisoning themselves.

Keep well,

And continue staying away from grains. :-)

Milla.

775bc83a7c54975e77a8500e065a24c3

(814)

on December 20, 2011
at 01:16 PM

excellent answer

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 03:00 PM

I make my food from scratch. I don't eat processed food except for coconut oil. And yet, I would love to have a (safe) pill I could take for the holiday season when work requires I go to someone's house, they cook gluten-free, and I want to be able to actually eat. My work also involves a lot of traveling to foreign countries for a few days to a week, and I'd love to be able to eat something other than pemmican when I'm there. I think you're being too strict here. The food paranoia I have to contend with, as a severely sensitive celiac, is disturbing, even eating my own unprocessed food.

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 03:02 PM

I make my food from scratch. I don't eat processed food except for coconut oil. And yet, I would love to have a (safe) pill I could take when I go to someone's house, they try to cook gluten-free, and I want to be able to actually eat. My work also involves a lot of traveling to foreign countries for a few days to a week, and I'd love to be able to eat something other than pemmican when I'm there. I think you're being too strict here. The food paranoia I have to contend with, as a severely sensitive celiac, is disturbing, and I'd love to be a normal gluten-free person once in a while.

B9637ddb9a9a5c6a7306e3c804fcd21d

(3217)

on December 20, 2011
at 03:53 PM

Sara - I didn't mean to completely debunk it - I do agree that this could be a useful tool in some circumstances where you really cannot control what you eat for severe celiacs.

1321554fbe74ad09e97c6e8c354021cc

(524)

on December 20, 2011
at 01:30 PM

Thanks, Milla. I hope you understood the ironic tone of "everyone" in the title of my post. I simply meant that, since science confers that gluten is not easily digested by some, and impossible to digest by others, we might use this as evidence to support a largely gluten-free, unprocessed diet for mainstream society. I wasn't at all suggesting that we should eat gluten to our tastebuds'-content, and take this "miracle" cure as a means of easing around the issue. But I think you get me. :-) And I agree with Edward. Excellent answer.

Cf4576cbcc44fc7f2294135609bce9e5

(3125)

on December 20, 2011
at 05:42 PM

i could not have said it better my self. seriously i dont write that eloquent

5
7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 03:15 PM

On the one hand, the past 5 months of learning just how sensitive to gluten I am have been really informative. On the other hand, the repeated bouts of diarrhea are wearing me down, and breaking my confidence and ability to function. So I wouldn't recommend everyone with gluten-sensitivity take a pill like this right away, as I think the learning experience is important, and unless they stay on the pill forever, they'll have to go through it at some point. (Unless the extra-sensitive period is just while healing, and once healed, you're not as stupidly sensitive... in which case, the pill could be great for getting through the extra-sensitive period.)

I would love a pill I could take on occasion to get me through hard times, such as when traveling or at gluten-free dinner parties at a friend's house. It breaks my heart for loved-ones to try to cook for me, but I can't eat it because the herbs they used could have been made in a factory that also contained gluten, or they didn't thoroughly scrub their counters before making the food, or their cutting board has cut gluten-containing foods at some point in the past, or there were gluten particles in the scratched parts of their non-stick frying pan. I could bring one of those celiac restaurant cards with me when I'm traveling, but do I really trust they'll be able to avoid cross-contamination to the levels I need (below 5ppm)? I would still eat gluten free, but a pill like this would give me that extra bit of assurance, like using spermicide on a condom.

24fcc21452ebe39c032be6801d6bbadd

(9812)

on December 21, 2011
at 03:07 PM

Cool, I hope they help! :)

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 06:05 PM

Yeah, I wonder that too. I highly doubt enough research would be done on it's safety and mechanisms of action before releasing it to the public, unfortunately.

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 06:05 PM

Yeah, I wonder that too. I highly doubt enough research would be done on its safety and mechanisms of action before releasing it to the public, unfortunately.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on December 20, 2011
at 03:43 PM

The key question might be, would such a pill retard your healing so the process took even longer. But I definitely would want the pill in your situation.

7841848bd0c27c64353c583fb7971242

(7275)

on December 21, 2011
at 01:50 PM

Hmm, it looks like the one you linked doesn't have the betaine hydrochloride, so it wouldn't cause me the same trouble as the NOW foods super enzymes. Thanks!

24fcc21452ebe39c032be6801d6bbadd

(9812)

on December 21, 2011
at 01:18 PM

Sara, have you tried digestive enzymes? I am probably a lot less sensitive than you, but I've had good results from taking these- http://www.amazon.com/Source-Naturals-Daily-Essential-Enzymes/dp/B000GFJJSI/ref=pd_sim_hpc_2 I eat gluten willingly from time to time, and most of the time I avoid symptoms if a take a few capsules.

7841848bd0c27c64353c583fb7971242

(7275)

on December 21, 2011
at 01:46 PM

Jules, good idea. I've tried NOW super enzymes a few times, but if I have a bout of diarrhea after I've taken them, it burns, so I'm holding off until things are more stable. It's interesting that they help you tolerate gluten: I'm guessing it helps your body break down the gliadin. I have celiac disease, so I can never eat a noticeable amount of gluten, but I would love to not have to worry about trace amounts.

5
A968087cc1dd66d480749c02e4619ef4

(20436)

on December 20, 2011
at 11:18 AM

Yes, everyone should take this pill. Thank god for modern medicine! And they should hand out statins with every burger at McDonalds.

See how "modern medicine" is so much better than "Big Pharma"?

A968087cc1dd66d480749c02e4619ef4

(20436)

on December 21, 2011
at 12:35 PM

As is a blanket dismissal of "Big Pharma". I'm not anti doctors, medicine or even drug companies. But I am skeptical of the "benefits" of many drugs - and wary of nasty side effects. The problem is that human biochemistry is massively complicated with many unknowns. Tampering with it should only be done with extreme caution (including dietary tampering). And btw, my answer was facetious (duh!) and simply for a laugh. Its also interesting to note that the language we use can change our perception of reality...

D10ca8d11301c2f4993ac2279ce4b930

(5242)

on December 20, 2011
at 06:21 PM

a blanket dismissal of modern medicine is naive.

4
9225c8e3ea353a2c604cacd62506047d

on December 20, 2011
at 02:42 PM

From what I gather ALV003 is an endopeptidase designed to 'break-up' those dastardly gluten epitopes: http://www.ncbi.nlm.nih.gov/pubmed/22153524 In effect, it's action is akin to what our own peptidase system should be doing when confronted with peptide chains from proteins such as gliadin and glutenin - splitting them up hopefully into small biologically-inactive peptides or even better their constituent amino acids. Pancreatic enzymes are routinely used in conditions such as cystic fibrosis; indeed many people are using various "digestive aids" to theoretically either support their own enzymatic systems (betaine HCL -- tri- and dimethylglycine for gut pH bearing in mind some enzymes are pH dependent) or the various protease / peptidase preparations (including bromelain) suggested to break 'em up. Talk to your doc before taking any of these because there may be contraindications based on any medication regime you are following.

7841848bd0c27c64353c583fb7971242

(7275)

on December 20, 2011
at 06:03 PM

This is interesting and helpful. Thanks for posting it.

3
082bf04a7486991c5e573a66f1404b3e

on December 20, 2011
at 09:21 AM

I think an "everymans-pill" is an oxymoron. Especially here ;)

2
96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on December 20, 2011
at 04:02 PM

I appreciate this thought-provoking question.

I have to admit the idea of being able to have a sesame-seed bagel on a holiday is a big carrot dangling right in front of me.

Along with many others on PH, though, I am skeptical if not downright suspicious of processed/refined supplements and medications. I'm more comfortable with something you can get in a food, or in concentrated form as an extract.

On the other hand, as someone with a hiatal hernia and no gallbladder, I'll stoop to taking bile acids after a very-high-fat meal if it means no problems at night.

So here I am straddling the fence big time! The inner child says, "WANT THAT!" The rest of me feels cautious and wary about interfering with natural healing and underlying reasons for intolerance.

1
03fa485bfd54734522755f47a5e6597e

(3944)

on December 21, 2011
at 03:03 PM

A friend of mine got something from her chiropractor/naturopath/nutritionist that supposedly somewhat counters the effect of gluten. The stated reason is like this product's: for very sensitive people to have some recourse if they accidentally ingest some gluten. But of course, my friend starts reaching for it if she's at a party and someone offers her a not-gluten-free brownie. To the extent that it works, I don't think that's what it's designed for, and she may be eating more gluten than she would if she didn't think she had this weapon against it. (She knows it doesn't counter the effects gluten completely, but she doesn't know whether it counters 1% or 99%, so in the face of a mouth-watering dessert and the social pressure of everyone else eating it, I'm sure wishful thinking kicks in.)

To me, this is like people who have severe allergy to bee stings, who carry medicine that will counter a bee sting enough that they won't die before they can get to a hospital. It's good that such medicine exists, obviously. But it doesn't mean these people should become beekeepers; they should avoid bees as much as possible and use the medicine as a last resort. And we shouldn't start putting it in the water supply for everyone just in case. Likewise, it'd be good if severely gluten-intolerant folks had something they could take in case of emergency to prevent the damage and sickness. But they shouldn't use it as an excuse to eat any gluten, and we shouldn't encourage mildly intolerant people (or everyone) to use it rather than changing their diet.

0
24fcc21452ebe39c032be6801d6bbadd

(9812)

on December 21, 2011
at 01:24 PM

I agree with Sara S.; a pill like this could be great as long as it's treated as extra insurance, rather than a "get out of jail free card." Of course gluten and processed foods are to be avoided, but people with Celiac can really get messed up by accidentally ingesting trace amounts of gluten, and if I had that condition, I would want any tools at my disposal I could get.

0
96440612cf0fcf366bf5ad8f776fca84

(19483)

on December 21, 2011
at 06:37 AM

Take a pill so I could eat a poison? Hmmm, let me think about that... Is Celiac Disease caused by a lack of this pill, or by grains?

A better question is whom does it benefit? Me? Or big pharama and big agra?

I'll skip both the pill and the wheat and spend the savings on grassfed meats. Thanks.

0
Cf4576cbcc44fc7f2294135609bce9e5

on December 20, 2011
at 05:46 PM

i think i will be hearing about this magic bullet down the road like vioxx made the news when it was found to kill people.LOL

0
Medium avatar

on December 20, 2011
at 05:09 PM

I am learning, smartly or not, to breeze right by claims made about what's good for Everybody, and what's good for Nobody. These get equally short shrift: Always and Never.

I allow exemptions, however, for lemmings.

Answer Question


Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!