8

votes

Do carnivorous animals (lions, cheetahs, etc) run on ketones or...?

Answered on September 12, 2014
Created May 29, 2012 at 1:50 PM

Do carnivorous animals run on ketones or do they run on a mixture of fat and glucose (gluconeogenesis)? Are they simply more efficient at converting protein to glucose than humans? Any information would be appreciated.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on June 12, 2012
at 07:41 PM

Yeah I wish I could find more on this. I do know that cats do not have ketotic breath.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on June 12, 2012
at 07:36 PM

Also cats do not have ketotic breath.

B3173217a49b5b0116078775a17eb21d

(11488)

on May 29, 2012
at 10:38 PM

I'm happy to be corrected though - I said I was guessing.

B3173217a49b5b0116078775a17eb21d

(11488)

on May 29, 2012
at 10:37 PM

@foreveryoung I thought I said that "but with advanced gluconeogenesis to supply glycogen for muscles". I am agreeing that they have a bigger capacity to generate glucose from protein (for muscle glycogen).

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 09:47 PM

@boro- but your intuition is in direct conflict from the very little information I could find on the subject. Apparently cats have an upregulated gluconeogenic pathway

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 09:45 PM

Why do you "bet" that carnivores run most of their CNS on ketones? The little I could find said that cats have an unregulated gluconeonic pathway.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 09:44 PM

Why do you "bet" that carnivores fuel the majority of their CNS on ketones? Cats apparently have an unregulated gluconeogenic pathways.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 09:40 PM

don't the Masai drink milk? Milk is not a low/no carb beverage.

77877f762c40637911396daa19b53094

(78467)

on May 29, 2012
at 06:17 PM

Do the Masai do a lot of HIT?

60af23519906aa54b742ffc17477c3d3

(1186)

on May 29, 2012
at 05:32 PM

Think it's possible to change our ability to perform better over time? I wonder if traditional cultures (Masai etc) have a differing ability to those of us raised on a SAD.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 02:18 PM

I just found this on felipedia.org "In cats, gluconeogenesis from amino acids is not downregulated even if protein intake is deficient. As a direct effect of a low carbohydrate intake under natural feeding conditions, cats have developed a high capacity for intensive gluconeogenesis from glucogenic amino acids[3]. The activity of gluconeogenic enzymes is much higher in cats than in dogs"

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 02:18 PM

Just found this on felipedia.org "beneficial effects in controlling nutrient metabolism in diabetic cats[2]. In cats, gluconeogenesis from amino acids is not downregulated even if protein intake is deficient. As a direct effect of a low carbohydrate intake under natural feeding conditions, cats have developed a high capacity for intensive gluconeogenesis from glucogenic amino acids[3]. The activity of gluconeogenic enzymes is much higher in cats than in dogs"

Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

2 Answers

4
B3173217a49b5b0116078775a17eb21d

(11488)

on May 29, 2012
at 02:33 PM

Glucose and ketones are complementary substrates for energy production in all mammals. Although we tend to associate them with "starvation" (or glucose starvation) in mammals, ketone bodies such as acetoacetate and ??-hydroxybutyrate are produced by the liver, and tissues such as heart muscle routinely derive much of their metabolic energy from oxidation of these compounds.

"Any standard biochemistry textbook will point out that ketone bodies are routinely being used for fuel in cardiac and skeletal muscle of higher animals. The brain only uses ketone bodies when glucose supplies are very low, such as during starvation '" http://www.jbc.org/content/272/34/21151.full

My bet is that carnivores with very little glucose intake, fuel their central nervous system with a minority of gluconeogensis generated glucose and majority of ketones (as human would), but with advanced gluconeogenesis to supply glycogen for muscles (in humans this process is limited - it's pretty hard to do high intensisty explosive exercise fuelled by gluconeogenesis alone).

I'm pretty much guessing though...

77877f762c40637911396daa19b53094

(78467)

on May 29, 2012
at 06:17 PM

Do the Masai do a lot of HIT?

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 09:45 PM

Why do you "bet" that carnivores run most of their CNS on ketones? The little I could find said that cats have an unregulated gluconeonic pathway.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 09:44 PM

Why do you "bet" that carnivores fuel the majority of their CNS on ketones? Cats apparently have an unregulated gluconeogenic pathways.

B3173217a49b5b0116078775a17eb21d

(11488)

on May 29, 2012
at 10:37 PM

@foreveryoung I thought I said that "but with advanced gluconeogenesis to supply glycogen for muscles". I am agreeing that they have a bigger capacity to generate glucose from protein (for muscle glycogen).

B3173217a49b5b0116078775a17eb21d

(11488)

on May 29, 2012
at 10:38 PM

I'm happy to be corrected though - I said I was guessing.

60af23519906aa54b742ffc17477c3d3

(1186)

on May 29, 2012
at 05:32 PM

Think it's possible to change our ability to perform better over time? I wonder if traditional cultures (Masai etc) have a differing ability to those of us raised on a SAD.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 09:47 PM

@boro- but your intuition is in direct conflict from the very little information I could find on the subject. Apparently cats have an upregulated gluconeogenic pathway

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on May 29, 2012
at 09:40 PM

don't the Masai drink milk? Milk is not a low/no carb beverage.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on June 12, 2012
at 07:41 PM

Yeah I wish I could find more on this. I do know that cats do not have ketotic breath.

1edb06ded9ccf098a4517ca4a7a34ebc

(14952)

on June 12, 2012
at 07:36 PM

Also cats do not have ketotic breath.

1
01adafcb4dd4147c6af543f61eee60a8

on June 12, 2012
at 08:54 PM

Great question atlast

Answer Question


Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!