0

votes

Optimal supplementation and food for methylation

Commented on June 07, 2014
Created June 05, 2014 at 11:32 PM

What is the easiest way to figure out the minimal effective dose of supplementation and dietary change to adjust for the following genetics?

It seems that I have minor defects, but nothing serious. All other things being equal, I would love to take ZERO supplements and get everything from food. Second best option is just taking one or two. I think I am currently covered on all key fronts (B1, B12, B6 and Folate) from food, but I am open-minded of trying supplementing. Is B Complex Plus by Pure Encapsulations is the best way to go or is it possible to come up with a more customized approach (avoid some and only take some)? How do I go about figuring out the optimal minimal possible combination in under 30 minutes of research? Thank you for your help!

Cf08ad26759fdd206a2c9f9385080a57

(995)

on June 07, 2014
at 03:34 AM

I would go by n=1 on how you feel with it. Some people have to start really low and slow with them or it's uncomfortable. If you don't notice much either way, then they're working well for you. If you start to feel like there's some excess, you can try a pinch of niacin (the flushing kind.) Something like a quarter of a 100mg when you feel like it would help. COMT is balanced out by VDR Taq, and with +/-'s for both it really depends on which genes you're expressing. The COMT-'s do well with methyls, and the VDR Taq+'s do well with the methyls, where you're somewhere in the middle.

B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on June 07, 2014
at 12:13 AM

There are also some interesting answers here: www.mthfrsupport.com/forums/topic/optimal-supplementation-and-food-for-methylation/ that seem to agree with your perspective that I don't need much.

Thanks a lot again!

B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on June 07, 2014
at 12:13 AM

Thank you very much for such a comprehensive and thoughtful respond!

I am thinking of probably going with no supplementation for now or experimenting with different forms of B12. I have been taking Nutrient 950 by Pure Encapsulations with methylated forms of vitamins and haven’t been experiencing significant issues with it. At least not in short-term. I say that I don't tolerate them well not based on personal feelings, but based on these guidelinesgeneticgenie.org/all-mutations/ that basically say that COMT means I don't handle them well (see my analysis below in separate post)

  • B121fdbc1aaa6130f5bda3bf84e3ba2d

    asked by

    (952)
  • Views
    1.5K
  • Last Activity
    1354D AGO
Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

3 Answers

best answer

0
Cf08ad26759fdd206a2c9f9385080a57

(995)

on June 06, 2014
at 09:19 PM

That looks like a great methylation panel to me. A66G is your only red mark, where that's a fairly mild mutation. A1298C is fairly mild as well, and you're hetero there. You could maybe eat some more seafood and veg (beets / spinach.) I would be happy with those genetics. I don't even see the need to supplement beyond perfecthealthdiet style recommendations.

BH4 supplementation is fairly under-researched at this point, and likely unnecessary in context of your full panel. You could try to limit your aluminum (maybe an alum-free deodorant?) And toss in a boron / silicon supplement and some trace minerals (ala PHD.)

Have you tried methyl donors in the past? (What makes you say that you don't tolerate methyl donors well?) You could take a b12, and I don't see any harm there if it feels good. If you go methylated folate (likely unnecessary in the context of your fully working long cycle and mostly unblocked BHMT shortcut), then, you might want to do b12 to prevent a slight potential for methyl-trapping, but again, I don't see the need for the extra folate, unless you like it and it seems to be working for you. Hydroxy-b12 is the one you get in meat, but with A66G, your slight issue is in recycling the methyl-b12. There's also adenosyl-b12, which is used in the mitochondria, but likely unnecessary to supplement. I'm not a fan of the cyano-form, as it's based off the cyanide molecule.

If you've got the cash, I would look into a UAA test for ammonia and a homocysteine blood test, just for kicks.

B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on June 07, 2014
at 12:13 AM

Thank you very much for such a comprehensive and thoughtful respond!

I am thinking of probably going with no supplementation for now or experimenting with different forms of B12. I have been taking Nutrient 950 by Pure Encapsulations with methylated forms of vitamins and haven’t been experiencing significant issues with it. At least not in short-term. I say that I don't tolerate them well not based on personal feelings, but based on these guidelinesgeneticgenie.org/all-mutations/ that basically say that COMT means I don't handle them well (see my analysis below in separate post)

B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on June 07, 2014
at 12:13 AM

There are also some interesting answers here: www.mthfrsupport.com/forums/topic/optimal-supplementation-and-food-for-methylation/ that seem to agree with your perspective that I don't need much.

Thanks a lot again!

0
B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on June 07, 2014
at 12:02 AM

There are also some interesting answers here: www.mthfrsupport.com/forums/topic/optimal-supplementation-and-food-for-methylation/

0
B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on June 06, 2014
at 08:45 PM

I did my own analysis based on this http://geneticgenie.org/all-mutations/ Here are the conclusions. Summary: - Trouble handling methyl donors (VDR+COMT) - 30%+ odds of decreased BH4 (Tetrahydrobiopterin) -> increased ammonia - Bad conversion of homocysteine to methionine - Avoid B6 (and B6?) (CBS A360A) http://mthfr.net/forums/topic/cbs-a360a-conflicti... - Dopamine & nopirenphrine - unclear - Folate / folic acid - unclear

Actions: - B12: Hydroxocobalin or cyanocobalamin - Some form of folate (not folic acid, but not methyl) on folate: http://mthfr.net/forums/topic/cbs-a360a-conflicti... - BH4 supplement However, I am about the following: 1. Is it better to go with B12 Hydroxocobalin or cyanocobalamin (methyl is not an option as I don't handle methyl groups well); 2. Is it better to take only B12 or folate as well? If folate as well, then what is the best form for me? I seem to need it as I don't convert 5-methylfolate (5MTHF) to tetrahydrofolate (THF) very well. But at the same time I cannot take methylfolate (methyl is not an option as I don't handle methyl groups well). What is the sollution? 3. Should I do anything in case my BH4 is indeed decreased (which is possible). What exactly and why?

Answer Question


Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!