5

votes

Hack my genetic test results -make them something useful!

Answered on August 19, 2014
Created September 12, 2011 at 8:45 PM

EDIT: Other PH posts are slightly different: My post is about my specific results.

I took this genetic test because I am at the bottom of the barrel as far as stuff to try for my health issues. So help me with a little speculation on trying to make something out of these results.

The results seem totally useless to me, even after reading all the info provided. I was hoping to get some speculation in order to stop feeling like I totally flushed money down the drain.

*I carry the genes for Hemocromatosis (but I have been severely anemic for over 15 years!) Does that mean the genes aren't active!? Or that a potential low-thyroid thing can override? *Slow caffeine metabolizing (Does this mean I stay on a coffee high for longer?) *Coumadin sensitivity (I have been told I have the fastest clotting blood in the west, so how does that pan out?). *Extremely Higher than average circulating SHBG (I have no idea what that means!) *Asparagus metabolite detector (methylation related? Does that mean I should avoid sulfurous foods?) *Two working copies of the fast-twitch muscles fiber genes that super athletes have. (From how I read it I am guessing that the muscles need less oxygen to work. Does this explain why, despite the horror of many doctors, I don't "feel" anemic in the slightest, but that maybe on the other hand, the anemia is holding my down from being a better athlete?

Any thoughts? (I did plug the raw data into that Neanderthal program and I was a 5/84. I tried to use promethease to find out more health info and it was going on 8 hours, so I cancelled.)

9f8e26e7d8a764e067efcb02516d85e2

(0)

on December 19, 2013
at 11:42 AM

Try NutraHacker

9f8e26e7d8a764e067efcb02516d85e2

(0)

on December 19, 2013
at 11:41 AM

www.nutrahacker.com ! Does the job!

6d22d9ac8fa0bcd905653395fb571674

(20)

on September 29, 2011
at 10:33 PM

I had low iron for several years and iron supplements didn't seem to help. I saw a Dr. who told me that you need iron in your blood to draw iron out of your digestive tract and that it is really hard to raise your blood iron levels through supplementation if you are already low. So he gave me iron supplementation through an IV and had me continue to take iron supplements. It worked and a year and a half later all of my iron related tests have come back excellent. Maybe you have tried this, but just in case I thought I'd share.

F1b39d4f620876330312f4925bd51900

(4090)

on September 13, 2011
at 03:13 PM

After years of doctors of every kind, I am in the 'doctors suck' camp right now. No ulcers, tons of stuff ruled out. A nutritionist I am working with right now thinks the low iron is from low thyroid (despite my healthy numbers).

Df7e22dbbb8c39f5006d0784feb03845

(175)

on September 13, 2011
at 01:46 AM

I'm really puzzled by the fact that you are both constipated and have low iron; especially low iron with a paleo diet. Have you had a full gastronology analysis done? My father had low-iron because of stomach ulcers. 15 years is a long time for low iron. I hope the doctors are working with you on this issue.

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 10:20 PM

Been there done that with every food trial-treatment-elimination. Thanks so much for speculating with me!! That's what I really wanted from the answers -just speculating and trying to figure things out. I tend to run on the C side of things so who knows!

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 10:13 PM

Rose -you summed up what I wanted exactly 'utility'!!

3aea514b680d01bfd7573d74517946a7

(11996)

on September 12, 2011
at 10:08 PM

Heh. Yeah, or be adopted, as I am. I still think there's some utility in these things, but I'll be damned if I can articulate what it is, lol. Maybe I just like geeking on (currently) useless data. I *am* sure that someday it won't be useless, though.

9d43f6873107e17ca4d1a5055aa7a2ad

on September 12, 2011
at 09:49 PM

lol, I guess it's more interesting if you have some sketchy people in your family like I do.

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 09:36 PM

Rose, My ancestral info was pretty lame too! Just showed the heritage I already knew I had. Boring! :)

6670b38baf0aae7f4d8ac2463ddc37c0

(3946)

on September 12, 2011
at 09:26 PM

Thanks for this question, can't help you, but just ordered my kit-very cool.

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 09:09 PM

If only eating well worked!! I was hoping the genetic test would shed some light on my current health issues. (Tummy troubles and anemia that no iron pill can crack). Ah well!

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 09:06 PM

I looked at the technical info but it would a bit over my head. I thought that the asparagus one wasn't just a silly inclusion but might have something to do with methylation of high thiol/sulphur containing foods. Thanks for the feedback!!

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4 Answers

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2
Df7e22dbbb8c39f5006d0784feb03845

(175)

on September 12, 2011
at 10:15 PM

Senneth, Your tummy problems may be covering up your ability to have high iron. If your diarrhea dominant, your iron may be just running out of you. If your constipated your iron levels should hypothetically be higher. Generally, people who are constipated have better mineral/vitamin counts. It can be a painful cycle when your with child. The progestern makes some women more constipated when their with child, so that you'll maintain more vitamins/minerals. Unfortunately, your stuck fixing your digestive issues on your own. I had to do a strict elimination diet to figure out what was causing my digestive issues. I have trouble with any amount of onion.

Amy

F1b39d4f620876330312f4925bd51900

(4090)

on September 13, 2011
at 03:13 PM

After years of doctors of every kind, I am in the 'doctors suck' camp right now. No ulcers, tons of stuff ruled out. A nutritionist I am working with right now thinks the low iron is from low thyroid (despite my healthy numbers).

Df7e22dbbb8c39f5006d0784feb03845

(175)

on September 13, 2011
at 01:46 AM

I'm really puzzled by the fact that you are both constipated and have low iron; especially low iron with a paleo diet. Have you had a full gastronology analysis done? My father had low-iron because of stomach ulcers. 15 years is a long time for low iron. I hope the doctors are working with you on this issue.

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 10:20 PM

Been there done that with every food trial-treatment-elimination. Thanks so much for speculating with me!! That's what I really wanted from the answers -just speculating and trying to figure things out. I tend to run on the C side of things so who knows!

6d22d9ac8fa0bcd905653395fb571674

(20)

on September 29, 2011
at 10:33 PM

I had low iron for several years and iron supplements didn't seem to help. I saw a Dr. who told me that you need iron in your blood to draw iron out of your digestive tract and that it is really hard to raise your blood iron levels through supplementation if you are already low. So he gave me iron supplementation through an IV and had me continue to take iron supplements. It worked and a year and a half later all of my iron related tests have come back excellent. Maybe you have tried this, but just in case I thought I'd share.

4
3aea514b680d01bfd7573d74517946a7

(11996)

on September 12, 2011
at 09:30 PM

Senneth, I feel your frustration, since you were looking to hack medical issues. Unfortunately, most of the gene correlations to medical conditions that we know of at present are just that: associations, correlations. And we know how dependable those are, don't we?

One way to look at it is that if you were to place bets on whether a pool of people with, say, the hemachromatosis SNP will actually develop the problem, you could make some money. But betting on any given individual within that pool (for example, you) is a much less certain proposition.

For this reason, I didn't look for much medical insight when I spit into the vial (I was mostly looking for ancestral info, which I'm very happy with). I'm deeply skeptical of service providers (doctors, counselors, nutritionists) who offer individualized health plans based on genetic information -- we are simply not at that point yet, and any such offering is snake oil, in my opinion. The best anyone can hope for at present is the kind of cautious information offered by the more reputable testing outfits, who (seem to) try their best to let people know that in most cases, we're talking about odds, not guarantees.

I'm sorry you feel you may have wasted your money. The one suggestion I do have, if you're feeling really glum about this, is to participate in the surveys and research snippets that they run on their site. This will help, even in a small way, to move research forward.

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 09:36 PM

Rose, My ancestral info was pretty lame too! Just showed the heritage I already knew I had. Boring! :)

9d43f6873107e17ca4d1a5055aa7a2ad

on September 12, 2011
at 09:49 PM

lol, I guess it's more interesting if you have some sketchy people in your family like I do.

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 10:13 PM

Rose -you summed up what I wanted exactly 'utility'!!

3aea514b680d01bfd7573d74517946a7

(11996)

on September 12, 2011
at 10:08 PM

Heh. Yeah, or be adopted, as I am. I still think there's some utility in these things, but I'll be damned if I can articulate what it is, lol. Maybe I just like geeking on (currently) useless data. I *am* sure that someday it won't be useless, though.

4
3f5bbb444498a24f1a9720d75fa7c903

on September 12, 2011
at 09:03 PM

Under each report, there is a tab that says Technical. If you click on this, you will get more info on your specific combination of alleles/genes and what it means. A lot of people have the hemochromatosis allele. Only certain combinations affect iron levels significantly. You can find your combination as described above. Both my husband and I have it as well as my daughter, but none of us have the combo needed for iron overload. I have never had any iron level problems however.

I have fast metabolism of caffeine. Apparently slow metabolism means that any benefits from caffeine are overided and it is possible that caffeine can be detrimental to you.

Coumadin sensitivity just means you will react to the drug as you are supposed to, so if you need it, it will work on you.

I'm not familiar with the SHBG one - just click on the technical report for more info.

Asparagus detector just means you can smell your urine quite strongly after you eat asparagus. It's kind of a fun but meaningless trait.

I also have fast twitch muscles which don't necessarily mean you are a super athlete but does tend to be better for lifting heavy things and sprinting.

I find 23andme results fascinating to look at but that is because I am a biology geek!

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 09:06 PM

I looked at the technical info but it would a bit over my head. I thought that the asparagus one wasn't just a silly inclusion but might have something to do with methylation of high thiol/sulphur containing foods. Thanks for the feedback!!

0
B82d4e636cc5f7e2c3422562a724ca72

(20)

on September 12, 2011
at 09:07 PM

Eat well,and try to do not become obsessive about genetic analysis, try to discover by experience too what work for You... Just to keep a different point of view..: http://www.youtube.com/watch?v=22zXjP38f_I&feature=related

F1b39d4f620876330312f4925bd51900

(4090)

on September 12, 2011
at 09:09 PM

If only eating well worked!! I was hoping the genetic test would shed some light on my current health issues. (Tummy troubles and anemia that no iron pill can crack). Ah well!

9f8e26e7d8a764e067efcb02516d85e2

(0)

on December 19, 2013
at 11:41 AM

www.nutrahacker.com ! Does the job!

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