6

votes

Can a PaleoHacker help me hack my 23andme data?

Answered on September 12, 2014
Created August 20, 2011 at 1:35 PM

Just got my 23andme data back -- would love to know what is the best way to get the most actionable data out of it.

What should I look at that will let me make a change in my diet, lifestyle, fitness today? Anything?

3aea514b680d01bfd7573d74517946a7

(11996)

on August 20, 2011
at 09:45 PM

Hiya, cousin! I also tan easily, despite being very pale in the winter. Since we're related, have you checked out this Neanderthal allele business posted by Melissa? http://paleohacks.com/questions/52325/how-neanderthal-are-you-and-what-is-your-ideal-diet-like#axzz1VbkuYQoi

1ac01c9caa991d3d6b6493eb61dc5cc2

(10)

on August 20, 2011
at 05:48 PM

Pathway Genomics has a really comprehensive report looking at the relationship between genetics and diet/nutrition and exercise (https://www.pathway.com/dna-reports/pathway-fit) but I don't see how you can order it? It sounds like you may have to go through your doctor :(

9d43f6873107e17ca4d1a5055aa7a2ad

on August 20, 2011
at 04:19 PM

maybe someone will make a more nutrition-focused version of the report someday

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5 Answers

4
9d43f6873107e17ca4d1a5055aa7a2ad

on August 20, 2011
at 03:44 PM

Hand's down it's Promethease. You'll get a full report that will pick out interesting genes, like those related to folate, iron, and vitamin A.

9d43f6873107e17ca4d1a5055aa7a2ad

on August 20, 2011
at 04:19 PM

maybe someone will make a more nutrition-focused version of the report someday

1ac01c9caa991d3d6b6493eb61dc5cc2

(10)

on August 20, 2011
at 05:48 PM

Pathway Genomics has a really comprehensive report looking at the relationship between genetics and diet/nutrition and exercise (https://www.pathway.com/dna-reports/pathway-fit) but I don't see how you can order it? It sounds like you may have to go through your doctor :(

3
3aea514b680d01bfd7573d74517946a7

(11996)

on August 20, 2011
at 03:16 PM

I wish I had a great list of actionable items to recommend; I've been trying to pull together the same thing for myself. The biggest issue for me is how much we don't know about what genes actually predict in real life. Except for some very powerful SNPs, correlations between certain gene sequences and, say, a given disease remain remarkably weak.

But until we learn how to really "read" our genomes, here are the few action-oriented things I've done:

Look at your APO?? snps and see which allele you have (warning: this is also the "Alzheimer's" allele, and some people choose to not know their risk for AD):

rs429358/rs7412

??2 = T/T

??3 = T/C

??4 = C/C

The APO?? gene has some correspondence to Vitamin D requirements, and according to Dr. Davis, is also related to how an individual responds to saturated fat (although I'm damned if I can find any solid references for this, other than his say-so).

I've also submitted several questions to 23andMe for their research snippets, but nothing related to nutrition or exercise, since I can't move beyond simple low-carb thinking, lol. I think it would be fantastic if some of you Paleo science geeks would submit thoughtful, well-formulated nutritional research questions.

Finally, I take my Ancestry painting stuff/haplotype group pretty seriously. Being female with no living male relatives directly related to my father, I can only know my maternal haplotype, which is H1a. I've spent the last couple of months looking at anthropological literature related to the time frame/geographical range of this haplotype, and have tried looking at my diet and lifestyle through that framework, a la Michael Rose. (The other issue there, of course, is what we actually know about lifestyles of the pre-agricultural.) Your information will be more complete, Patrik, so will either provide more insight or more opportunities for confusion.

1
3f5bbb444498a24f1a9720d75fa7c903

on August 20, 2011
at 04:36 PM

I'm H1a as well, Rose, so we are related. :) I found this part of the information to be interesting since my family tends to tan easily yet we are all from the northernmost parts of Europe. The move from the Iberian peninsula might explain those tanning alleles. I also only have my maternal haplotype but my daughter just sent in her sample and I hope to glean a little more info from her results. I did find that I carry an allele for a mild variant of hemochromatosis (which may explain why I get sick from iron-containing vitamins) and I am also more at risk from blood clots because I carry the Leiden V factor (good to know if I ever have surgery). I find it a bit more helpful to know which genes I do NOT have - I have none of the known BRCA genes for example, which is somewhat comforting. I'm a biology geek so I find it fun to just hunt around on the site in general.

3aea514b680d01bfd7573d74517946a7

(11996)

on August 20, 2011
at 09:45 PM

Hiya, cousin! I also tan easily, despite being very pale in the winter. Since we're related, have you checked out this Neanderthal allele business posted by Melissa? http://paleohacks.com/questions/52325/how-neanderthal-are-you-and-what-is-your-ideal-diet-like#axzz1VbkuYQoi

1
5b4fd1d0dcb02b1cc3c666ece9e5983d

(1169)

on August 20, 2011
at 04:14 PM

23andme - I got their 2010 DNA Day sale for 99 dollars, which was the best deal of my life. I have however hit the wall in terms of what to with the info - so this is a great thread.

0
9f8e26e7d8a764e067efcb02516d85e2

on December 19, 2013
at 11:40 AM

@Bread-Eating Beelzebub, @Rose Lake, @Laurie D., @Paleo P

www.nutrahacker.com does this type of analysis

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