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Calling all APOE 4/4

Answered on August 19, 2014
Created February 25, 2013 at 10:07 AM

For those who got APOE 4/4 result on genetic testing (http://snpedia.com/index.php/APOE).

What have you learned during your experimentation with diet, supplementation and with overall lifestyle changes?

B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on February 27, 2013
at 08:50 AM

I have create a new, more detailed post, please, join in and upvote! http://paleohacks.com/questions/182079/ultimate-apo-4-4-paleo-hacking-thread#axzz2M0WN91dm

7e6644836cdbcbe2b06307ff7db92d31

(693)

on February 25, 2013
at 03:21 PM

This sounds like a typical switch to a lower carb paleo. How does it relate to e4/e4?

7e6644836cdbcbe2b06307ff7db92d31

(693)

on February 25, 2013
at 01:58 PM

Curious what your looking for. Effect on blood work?

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2 Answers

1
7e1433afbb06c318c4d90860d493c49d

(5959)

on February 25, 2013
at 02:22 PM

I'm E4/E4. During my 20s and 30s, my diet was heavily influenced by Indian vegetarianism, with a heavy emphasis on grains and beans. This resulted in a flabby, lethargic descent into middle age. In September 2003, I drastically cut back on all starches to two slices of sprouted grain bread per day, and I lost 30 pounds over the following 5 months. A couple years after that, I ditched grains completely except occasionally. What works for me is a diet that is 50-60% fat; it's not strictly low-carb, but it's low enough in carbs that it doesn't launch me on the blood sugar roller coaster.

With respect to Alzheimer's, my reasoning is that since it is considered to be diabetes of the brain, I figure a diet that keeps glucose metabolism operating smoothly is a good strategy. And, because food at night negatively impacts the quality of my sleep, my very light evening snack of fruit or veggies at 5pm means I end up doing 12 hour fasts every day, which may also be a good thing.

7e6644836cdbcbe2b06307ff7db92d31

(693)

on February 25, 2013
at 03:21 PM

This sounds like a typical switch to a lower carb paleo. How does it relate to e4/e4?

B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on February 27, 2013
at 08:50 AM

I have create a new, more detailed post, please, join in and upvote! http://paleohacks.com/questions/182079/ultimate-apo-4-4-paleo-hacking-thread#axzz2M0WN91dm

0
B121fdbc1aaa6130f5bda3bf84e3ba2d

(952)

on February 27, 2013
at 08:51 AM

I have created new, more detailed post, please, join in and upvote! http://paleohacks.com/questions/182079/ultimate-apo-4-4-paleo-hacking-thread#axzz2M0WN91dm

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