8

votes

Would you be prepared to test your APOe gene?

Answered on August 19, 2014
Created June 28, 2012 at 2:22 PM

The APOe gene encodes for a protein associated with triglyceride metabolism but its also implicated in Alzheimer's disease.

It has been suggested that a variant of the APOe gene - APOe4 - may confer a survival advantage at times of famine (1) - a classic paleo gene.

APOe4 is believed to help the body conserve cholesterol (cholesterol is essential for cell membrane maintenance and hormone production). This is great during times of starvation but not so helpful when there is an abundance of cholesterol-rich foods.

Knowing about one's APOe gene may help plan the most appropriate diet and exercise routine.

However, this genetic variant has also been associated with a significantly increased risk of Alzheimer's disease - something that many people may prefer not to know about.

Would you be prepared to test your APOe gene?

(1) Ann Hum Genet. 1999 Jul;63(Pt 4):301-10. Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele? Corbo RM, Scacchi R.

Fd70d71f4f8195c3a098eda4fc817d4f

(8014)

on September 07, 2013
at 01:28 AM

I think a lot of the research on E4s and fat/cholesterol has not been conducted in the context of a LC diet. So when an E4 homozygote eats a "relatively" high/normal amount of fat *while still consuming a SAD-type of refined carbs,* yes, of course they're gonna have dyslipidemia. The research I've seen so far suggests that any eating/lifestyle strategy diet that maintains good insulin sensitivity for as long as possible is likely protective against AD. (BUT, to be honest, I haven't focused too much on the lipid side b/c my thesis is specifically about AD as "Type 3 Diabetes.")

2e6e673ce3eb647407d260d4d57a731b

(1021)

on November 12, 2012
at 09:23 PM

that may be your definition, but grok didnt have technology (since so many people want to go down that road). in fact the most paleo thing anybody can do is not give a shit what others eat and not care about trying to extend your life another 5 years.

77877f762c40637911396daa19b53094

(78467)

on November 12, 2012
at 06:28 AM

that's an interesting view given paleo is the dietary regimen that is based on an ancestral genotype

77877f762c40637911396daa19b53094

(78467)

on October 23, 2012
at 01:34 PM

Is there a policy against me doing some cosmetic housekeeping on my questions?

3ce6a0d24be025e2f2af534545bdd1d7

(26217)

on October 23, 2012
at 01:22 PM

Harry, Please stop making minor, superficial edits to your questions so that they get moved to the top of the list again. You've done it with 9 questions in the last 15 minutes.

77877f762c40637911396daa19b53094

(78467)

on June 29, 2012
at 12:40 AM

I suspect that e4 will turn out to be more advantageous provided one adjusts diet and exercise to suit. See 23andme https://www.23andme.com/you/community/thread/9388/

Fd70d71f4f8195c3a098eda4fc817d4f

(8014)

on June 28, 2012
at 10:27 PM

I think a lot of the research on E4s and fat/cholesterol has *not been conducted in the context of a LC diet.* So when an E4 homozygote eats a "relatively" high/normal amount of fat *while still consuming a SAD-type amount of refined carbs,* yes, of course they're gonna have dyslipidemia. The research I've seen so far suggests that any eating/lifestyle strategy diet that maintains good insulin sensitivity for as long as possible is likely protective against AD. BUT, to be honest, I haven't focused too much on the lipid side b/c my thesis is specifically about AD as "Type 3 Diabetes."

Fd70d71f4f8195c3a098eda4fc817d4f

(8014)

on June 28, 2012
at 10:25 PM

I think a lot of the research on E4s and fat/cholesterol has *not been conducted in the context of a LC diet.* So when an E4 homozygote eats a "relatively" high/normal amount of fat while still consuming a SAD-type of refined carbs, yes, of course they're gonna have dyslipidemia. The research I've seen so far suggests that any eating/lifestyle strategy diet that maintains good insulin sensitivity for as long as possible is likely protective against AD. (BUT, to be honest, I haven't focused too much on the lipid side b/c my thesis is specifically about AD as "Type 3 Diabetes.")

Fd70d71f4f8195c3a098eda4fc817d4f

(8014)

on June 28, 2012
at 10:25 PM

I think a lot of the research on E4s and fat/cholesterol has *not* been conducted in the context of a LC diet.* So when an E4 homozygote eats a "relatively" high/normal amount of fat *while still consuming a SAD-type of refined carbs,* yes, *of course* they're gonna have dyslipidemia. The research I've seen so far suggests that any eating/lifestyle strategy diet that maintains good insulin sensitivity for as long as possible is likely protective against AD. (BUT, to be honest, I haven't focused too much on the lipid side b/c my thesis is specifically about AD as "Type 3 Diabetes.")

7e1433afbb06c318c4d90860d493c49d

(5959)

on June 28, 2012
at 10:18 PM

Lowish carb paleo with some dairy (cream, butter, and yogurt, with cheese kept to a minimum). What I avoid the most is starch.

5e92edc5a180787a60a252a8232006e9

(345)

on June 28, 2012
at 07:58 PM

And what kind of diet are you on to keep your cholesterol at those levels?

21b36b3de8ff31b0d41e7f0f4b5c1e03

(1688)

on June 28, 2012
at 07:57 PM

I just did the same thing and am ε3/ε3 (lower odds) and 2.2% Neanderthal.

7e1433afbb06c318c4d90860d493c49d

(5959)

on June 28, 2012
at 05:09 PM

Years ago, I had originally tested with version 2, which didn't cover that genetic sequence, so I had to retest with version 3. I stopped getting cholesterol tests a couple years ago, but my readings were always in the same range. Last test: TTL = 231, HDL = 55, TRIG = 70, LDL (calculated) = 162

5e92edc5a180787a60a252a8232006e9

(345)

on June 28, 2012
at 04:24 PM

Why ru focusing on sugar? And why would LC be best for E4? Doesn't E4 alleles exaggerate the effect of Fat, resulting in high TC and LDL? Shouldn't E4s really be on a moderate carb / moderate fat diet in order not to fall in the FH range?

5e92edc5a180787a60a252a8232006e9

(345)

on June 28, 2012
at 04:21 PM

Bummer on the homozygous E4. How's your cholesterol? But why did you have to upgrade? Doensn't the test result appear as long as you're a $9 per month due paying member?

Fd70d71f4f8195c3a098eda4fc817d4f

(8014)

on June 28, 2012
at 03:04 PM

And yes, E4 is much more common among hunter-gatherers and their descendants, which makes carriers horribly unsuited to our modern grain and sugar-heavy diets. The other alleles are more common in populations that have the longest history of agriculture, and therefore theoretically are the best adapted to eat grain. I know "low carb" is like a 4-letter word around here these days, but if you're E4 and have a family history of AD, you definitely wanna keep the carbs lowish. (Veg and fruit are fine. Tons of pasta, bread, and cereal? Not so much.)

Fd70d71f4f8195c3a098eda4fc817d4f

(8014)

on June 28, 2012
at 03:01 PM

Dude...writing my thesis on Alzheimer's right now. If you *were* a carrier for APOE4, the best thing you can do is a low carb Paleo diet anyway, so it's all good! The connection btw Alzheimer's and insulin dysregulation is STUNNING. Have E4 and want to stave off dementia? Lay off the sugar. (And even if you *don't* carry the E4 allele, that doesn't give you a free pass. Chronic hyperinsulinism alone is enough of a risk factor. But ppl with hyperinsulinemia *and* E4 have a double whammy working against them. Either way: CONTROL INSULIN levels over the long haul. And eat real food!

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4 Answers

2
7e1433afbb06c318c4d90860d493c49d

(5959)

on June 28, 2012
at 03:52 PM

I upgraded my 23andme account specifically so I could see my APOe results. I'm a double E4. I'm also 2.9% Neanderthal.

21b36b3de8ff31b0d41e7f0f4b5c1e03

(1688)

on June 28, 2012
at 07:57 PM

I just did the same thing and am ε3/ε3 (lower odds) and 2.2% Neanderthal.

7e1433afbb06c318c4d90860d493c49d

(5959)

on June 28, 2012
at 05:09 PM

Years ago, I had originally tested with version 2, which didn't cover that genetic sequence, so I had to retest with version 3. I stopped getting cholesterol tests a couple years ago, but my readings were always in the same range. Last test: TTL = 231, HDL = 55, TRIG = 70, LDL (calculated) = 162

7e1433afbb06c318c4d90860d493c49d

(5959)

on June 28, 2012
at 10:18 PM

Lowish carb paleo with some dairy (cream, butter, and yogurt, with cheese kept to a minimum). What I avoid the most is starch.

5e92edc5a180787a60a252a8232006e9

(345)

on June 28, 2012
at 04:21 PM

Bummer on the homozygous E4. How's your cholesterol? But why did you have to upgrade? Doensn't the test result appear as long as you're a $9 per month due paying member?

5e92edc5a180787a60a252a8232006e9

(345)

on June 28, 2012
at 07:58 PM

And what kind of diet are you on to keep your cholesterol at those levels?

77877f762c40637911396daa19b53094

(78467)

on June 29, 2012
at 12:40 AM

I suspect that e4 will turn out to be more advantageous provided one adjusts diet and exercise to suit. See 23andme https://www.23andme.com/you/community/thread/9388/

1
81181cab058dd652659e4bb2e6f25843

(528)

on November 07, 2012
at 02:23 AM

I would absolutely like to take the apoE test. Whether I know about it or not the effects will still ring clear, better to know so a potential threat may be better mitigated.

0
7e6644836cdbcbe2b06307ff7db92d31

(693)

on June 28, 2012
at 03:25 PM

I believe you had another question up about genetic testing yesterday.

All I can say is that for the foreseeable future, I'd be much more interested in offering the APOe test (along with other screens) than actually getting it.

Too bad that won't happen.

-1
2e6e673ce3eb647407d260d4d57a731b

(1021)

on November 11, 2012
at 02:32 AM

nah, genetics testing is as anti paleo as you can get.

77877f762c40637911396daa19b53094

(78467)

on November 12, 2012
at 06:28 AM

that's an interesting view given paleo is the dietary regimen that is based on an ancestral genotype

2e6e673ce3eb647407d260d4d57a731b

(1021)

on November 12, 2012
at 09:23 PM

that may be your definition, but grok didnt have technology (since so many people want to go down that road). in fact the most paleo thing anybody can do is not give a shit what others eat and not care about trying to extend your life another 5 years.

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