The APOe gene encodes for a protein associated with triglyceride metabolism but its also implicated in Alzheimer's disease.
It has been suggested that a variant of the APOe gene - APOe4 - may confer a survival advantage at times of famine (1) - a classic paleo gene.
APOe4 is believed to help the body conserve cholesterol (cholesterol is essential for cell membrane maintenance and hormone production). This is great during times of starvation but not so helpful when there is an abundance of cholesterol-rich foods.
Knowing about one's APOe gene may help plan the most appropriate diet and exercise routine.
However, this genetic variant has also been associated with a significantly increased risk of Alzheimer's disease - something that many people may prefer not to know about.
Would you be prepared to test your APOe gene?
(1) Ann Hum Genet. 1999 Jul;63(Pt 4):301-10. Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele? Corbo RM, Scacchi R.
asked bypaleohacks (78467)
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on June 28, 2012
at 03:52 PM
I upgraded my 23andme account specifically so I could see my APOe results. I'm a double E4. I'm also 2.9% Neanderthal.
on November 07, 2012
at 02:23 AM
I would absolutely like to take the apoE test. Whether I know about it or not the effects will still ring clear, better to know so a potential threat may be better mitigated.
on June 28, 2012
at 03:25 PM
I believe you had another question up about genetic testing yesterday.
All I can say is that for the foreseeable future, I'd be much more interested in offering the APOe test (along with other screens) than actually getting it.
Too bad that won't happen.