1

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Alternatives to PPI for Ulcer?

Answered on August 19, 2014
Created August 24, 2013 at 3:47 AM

After an endoscopy, I've been diagnosed with superficial gastric ulcers. A biopsy and urea breath test for H.Pylori was negative. My doctor prescribed Nexium for six weeks.

I believe that PPI's do more harm than good; however I also want to heal my ulcers. Are there any alternatives?

I've done a lot of reading on Paleohacks, and I've seen answers like "Stop all NSAIDS" or "Stop gluten, coffee, caffeine, etc". But please note:

  • I follow a clean diet and avoid gluten, dairy (except for occasional cheese), no caffeine and now avoid sugar.
  • I do not take NSAIDS of any kind, or any other prescription drug
  • I do not smoke or drink, or do recreational drugs.
  • I'm currently trying a FODMAPs diet.

Any suggestions? Are H2 blockers any better? What about Calcium Carbonate?

543a65b3004bf5a51974fbdd60d666bb

(4493)

on August 25, 2013
at 01:43 AM

the following 'symptoms' coincided with me taking Nexium, can't say for sure if all were related & some may have been in my mind (as i did not really want to be on a PPI)...they were; shoulder/high-back aches & pains, general muscle aches & pains, night cramps (mainly calves i think), small but noticeable increase in fat coverage on torso & chest area. All these symptoms stopped or reversed once i stopped Nexium & did not occur on Nizatidine.

C295836e82538b73be87fc578782bc26

(5)

on August 24, 2013
at 09:47 PM

Would you recommend Ranitidine over PPIs? Side-effect-wise?

C295836e82538b73be87fc578782bc26

(5)

on August 24, 2013
at 08:59 PM

I've read that stomach ulcers are often caused by TOO LOW stomach acid. Now how are you supposed to treat that?

C295836e82538b73be87fc578782bc26

(5)

on August 24, 2013
at 08:57 PM

Yes, I agree about gut dysbiosis. My ulcers were in the stomach near the duodenum, and I've read that this could be caused by bile refluxing into the stomach and dissolving the mucus. In turn, bile reflux could be caused by gas pressure from SIBO or other. overgrowth. I'm now taking monolaurin and oregano oil.

C295836e82538b73be87fc578782bc26

(5)

on August 24, 2013
at 08:54 PM

Very helpful links. What did you think the Nexium side effects were? And thanks for the warning about Cimetidine.

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3 Answers

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2
543a65b3004bf5a51974fbdd60d666bb

(4493)

on August 24, 2013
at 05:25 AM

I took Nexium for a bit, not for an ulcer tho, i had silent reflux/night-time reflux.
I was a bit wary of PPI's as well.
Anyway, i reckon i had side effects from nexium (let me know if you want more details & i'll dig up some old notes on what i 'think' those side effects were).
The nexium didn't seem to help either.

Then i took Nizatidine which did seem to help, plus i was happier because i was not on one of the PPI 'big guns'.
Nizatidine is one of later H2-receptor antagonist, i seem to remember some studies or articles (sorry no links handy), suggesting trying H2-receptor antagonists as the 1st step* before trying PPI's (but docs tend to jump straight to PPI's these days). * i should say i was just researching reflux at the time, not ulcers (so may be different).

If you do decide to give an H2-receptor antagonist a go, avoid Cimetidine (there seem to be too many reported side effects associated with Cimetidine, including reversible gynecomastia & male sexual dysfunction).

C295836e82538b73be87fc578782bc26

(5)

on August 24, 2013
at 08:54 PM

Very helpful links. What did you think the Nexium side effects were? And thanks for the warning about Cimetidine.

543a65b3004bf5a51974fbdd60d666bb

(4493)

on August 25, 2013
at 01:43 AM

the following 'symptoms' coincided with me taking Nexium, can't say for sure if all were related & some may have been in my mind (as i did not really want to be on a PPI)...they were; shoulder/high-back aches & pains, general muscle aches & pains, night cramps (mainly calves i think), small but noticeable increase in fat coverage on torso & chest area. All these symptoms stopped or reversed once i stopped Nexium & did not occur on Nizatidine.

1
75d65450b6ff0be7b969fb321f1200ac

(2506)

on August 24, 2013
at 12:49 PM

I had an H. pylori infection that caused a duodenal ulcer. I was treated for the infection, which included taking a megadose of omeprazole for 10 days. The ulcer retreated but it seems to reconstitute itself every few months, which apparently is not at all uncommon. Taking generic ranitidine (150 mg) twice daily for several days quiets it down very nicely. Since ranitidine is so cheap ($4 for a month's supply at Target/Walmart) and has a good safety profile I suggest giving it a try. But as with any drug, avoid taking it on a long term basis.

Having said all this, I don't think PPIs are horrible if taken for an interim period. They only cause serious problems if taken for a long periods.

_Lazza

C295836e82538b73be87fc578782bc26

(5)

on August 24, 2013
at 09:47 PM

Would you recommend Ranitidine over PPIs? Side-effect-wise?

1
F5a0ddffcf9ef5beca864050f090a790

(15515)

on August 24, 2013
at 04:59 AM

I wish I knew the answer myself.

Instead of answering your question, could I tell something that I know for sure?

  1. Most people who have ulcers have compromised gut bacteria (gut dysbiosis) as well.

  2. PPIs and acid reducers create an environment perfect for Candida and tons of gut-unfriendly bacteria.

  3. Causes of gastritis and ulcers (besides H.Pylori) are poorly understood.

  4. I have tried DGL and cabbage juice. It did not work for me because the root cause was not addressed. Look for the root cause.

  5. Sugar, gluten and vegetable oils are some of your worst enemies when it comes to treating ulcers. Bone broth is your friend. Try low-hystamine fermented foods as well.

  6. Lower your stress - ulcers come from high stress. Spend more time in nature and take your time for eating, make sure your meal time is enjoyable.

  7. I highly highly highly recommend using herbal adaptogens. My favorite is Rhodiola Rosea. I make tea with it. The best stuff on earth. You can also try eleutherococcus or some other ones, since different people react to them differently.

That's what I know for now. Good luck!

C295836e82538b73be87fc578782bc26

(5)

on August 24, 2013
at 08:57 PM

Yes, I agree about gut dysbiosis. My ulcers were in the stomach near the duodenum, and I've read that this could be caused by bile refluxing into the stomach and dissolving the mucus. In turn, bile reflux could be caused by gas pressure from SIBO or other. overgrowth. I'm now taking monolaurin and oregano oil.

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