I've seen a few questions and answers touch on this, but I'm curious: Has anyone been treated for hetero- or homozygous methylenetetrahydrofolate reductase (MTHFR, aka "Motherf***er) enzyme deficiency? If so, what symptoms were you having previously that supplementation has alleviated?
I ask because I'm in the beginning stages of going through functional medicine channels to hack my mood issues, fatigue, and brain fog. They seem to think this may be the magic bullet for me. That would be lovely, but I'm a skeptic.
I plan to start taking some phosphorylated B-Complex supps they gave me, but the test results won't be back for a few weeks. They say if I start feeling better, then we can rest assured this is something that's going on.
So how'd it work for you?
asked byKaren_P_ (7660)
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on August 06, 2012
at 11:19 PM
I love that you call it the Motherf***er enzyme, too. When I talk about it, that's always what I say. Because it really is a mother f*er.
I found out that I'm hetero for the C677T mutation with a 23andme analysis. I started supplementing with methylcobalamin, folate, and a bunch of other b vitamins, and within about a week or two I was feeling much better. My symptoms were fatigue, brain fog, difficulty concentrating, anxiety, depression. It has been bad enough that I'm at risk of losing my job. I'm getting better, but still not back to normal.
The enzyme activity if you're heterozygous is not that much reduced from normal: 56% enzyme activity for C677T compared to 67% for C677C (wild type), so about 84% the activity of normal. I think the reason it was so bad for me is because I have celiac disease, including 2 years of chronic diarrhea, so I wasn't able to absorb much in the way of b vitamins. I tried getting blood tests to determine my B12 and folate status, but I had already started taking the vitamin supplements and so I don't know how to interpret my low-end-of-normal results.
Edited to add: I started the B supplementation about a year after starting paleo, including near-weekly liver and oysters. So in my case, I wasn't able to get enough from a solid meal-plan.
on August 07, 2012
at 03:50 AM
According to 23andme I'm homozygous with only 33% enzyme activity. Though my blood work shows normal histamine, folate, methionine, and homocysteine levels. Supplementing with B-vitamins and TMG hasn't really helped anything. The search is still on.
on August 07, 2012
at 03:40 AM
I call it that too! I'm heterozygous.
I've been taking it for a year. Sadly, it has not helped my vitiligo, though I am horrible at remembering to take pills, so I have periods where I don't get it in every day.
I didn't have brain fog, etc., but I will say that my anxiety, always on the higher end, is sooooo much better. I've always been a worrier, and I had no idea what it was like not to worry so much and obsess about everything. Not to say that I don't worry at all, but I think it's at a more normal level now.
on April 09, 2013
at 01:26 PM
Okay, so this is an old thread, but hopefully someone will get the notification and help a girl out! I hear all this talk about the MTHFR SNP that is found on 23andME, but where is it? I have been staring at my 23andME results and I can't seem to find it?! Am I that dense?