3

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Avoid Folic Acid or not?

Answered on August 19, 2014
Created October 20, 2011 at 2:03 PM

I have read in several places that it is best to avoid Folic Acid supplementation because it is not a natural form of Folate and has been correlated to negative outcomes in some studies. Some multivitamins have started using alternatives likes Metafolin. But looking at the ???Daily Supplement Regimen??? question going on now, it looks like this concern of Folic Acid is not very widespread.

Should we avoid Folic Acid or not? How do the alternatives compare?

Edit:

I don't remember all the sources and links, but I saw this recently:

???Folic acid and iron ??? two nutrients we regard as dangerous and recommend not supplementing ??? both elevate mortality, as we would expect.??? - Paul Jaminet from here: http://perfecthealthdiet.com/?p=4895

Emily at Evolutionary Pyschiatry did not seem to be a big fan: http://evolutionarypsychiatry.blogspot.com/2011/08/folate-beginning.html

Chris Kresser: http://chriskresser.com/9-steps-to-perfect-health-4-supplement-wisely

Here are a couple of links I googled: http://www.healthknot.com/folic_acid_studies.html http://the.honoluluadvertiser.com/article/2010/Jan/21/il/hawaii1210305.html

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on October 20, 2011
at 09:40 PM

Thanks, Phoenix! That's pretty much what I recommend to my clients, anyway.

76f3ead3aa977d876bcf3331d35a36e9

(4620)

on October 20, 2011
at 09:28 PM

Here's Paul Jaminet's comment when asked about pregnancy folate strategy: http://perfecthealthdiet.com/?p=4895#comment-34654

6498694060d879a7960b35913539b75f

(1307)

on October 20, 2011
at 09:15 PM

Thanks, Dragonfly. It would be so much easier if I could just chow down a box of cereal every day. But I guess that is out of the question! ;-)

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on October 20, 2011
at 09:13 PM

PaleoDel~ After my first read-through of the cancer studies mentioned, I'm not so concerned. I certainly didn't see •conclusive• evidence that folic acid supplements cause cancer. I wouldn't worry about it for the length of your pregnancy.

6498694060d879a7960b35913539b75f

(1307)

on October 20, 2011
at 08:19 PM

As a pregnant lady, this concerns me greatly. I am currently taking a prenatal vitamin that includes folic, in addition to a sublingual multi-B that includes folic acid, all on doctor's orders. I don't want to endanger my child by not taking it, but I don't want to get cancer either. I just keep telling myself this is only for a short period of time.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 20, 2011
at 04:41 PM

There is no convincing evidence that the problem with folic acid supplements do not apply to natural folate as well. It is possible it is a synthetic vs. natural issue, but it is also possible that the problem is simply folate. After all, folate exerts epigenetic effects and excessive folate may lead to promoter hypermethylation (gene silencing).

020053fd576e93d1d8fa20bfb10979b9

(410)

on October 20, 2011
at 02:54 PM

Emily Deans talks about it here http://evolutionarypsychiatry.blogspot.com/search?q=folic+acid

7d64d3988de1b0e493aacf37843c5596

(2861)

on October 20, 2011
at 02:46 PM

Dragonfly, I added a couple of links I could remember off-hand and googled a couple of others. I think I have encountered Paul Jaminet's attitude fairly frequently, but I don't remember all the specifics. Maybe somebody else could supply more.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on October 20, 2011
at 02:21 PM

Links to your sources, please?

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2 Answers

2
Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on October 20, 2011
at 05:29 PM

Sorry, not an answer, but I couldn't fit it all in the comments.

This is really interesting. I appreciate you bringing it up, Paleo2.0! As a Pregnancy coach, I really need to know about this topic.

So here we have some folks (the ones you referenced) saying folic acid supplementation is potentially dangerous. And it maybe toxic to certain embryos :http://hmg.oxfordjournals.org/content/early/2011/06/21/hmg.ddr289.abstract.

And here we have the American Academy of Pediatrics promoting supplementation to prevent neural tube defects as well as stating that dietary folate is not as available as folic acid: http://aappolicy.aappublications.org/cgi/content/full/pediatrics;104/2/325

I've got lots of reading to do!

More study sources would be welcome.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on October 20, 2011
at 09:40 PM

Thanks, Phoenix! That's pretty much what I recommend to my clients, anyway.

6498694060d879a7960b35913539b75f

(1307)

on October 20, 2011
at 08:19 PM

As a pregnant lady, this concerns me greatly. I am currently taking a prenatal vitamin that includes folic, in addition to a sublingual multi-B that includes folic acid, all on doctor's orders. I don't want to endanger my child by not taking it, but I don't want to get cancer either. I just keep telling myself this is only for a short period of time.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on October 20, 2011
at 09:13 PM

PaleoDel~ After my first read-through of the cancer studies mentioned, I'm not so concerned. I certainly didn't see •conclusive• evidence that folic acid supplements cause cancer. I wouldn't worry about it for the length of your pregnancy.

6498694060d879a7960b35913539b75f

(1307)

on October 20, 2011
at 09:15 PM

Thanks, Dragonfly. It would be so much easier if I could just chow down a box of cereal every day. But I guess that is out of the question! ;-)

76f3ead3aa977d876bcf3331d35a36e9

(4620)

on October 20, 2011
at 09:28 PM

Here's Paul Jaminet's comment when asked about pregnancy folate strategy: http://perfecthealthdiet.com/?p=4895#comment-34654

0
E5c7f14800c5992831f5c70fa746dc5c

(12857)

on October 20, 2011
at 02:38 PM

avoid because its not found in food. Chris masterjohn and chris kesser have both covered this issue.

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