2

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What do you think of Tim Ferriss' PAGG supplementation? (Particularly EGCG's)

Answered on September 12, 2014
Created April 24, 2011 at 4:19 AM

I'm particularly interested on Tim Ferriss' claims that EGCG "appears to increase programmed cell death (apoptosis) in mature fat cells... The ease which people regain fat is due to a certain "fat memory" (the size of fat cells decreases, but not the number)."

http://www.amazon.com/Life-Ext...

http://www.amazon.com/gp/product/030746363X?ie=UTF8&tag=beeandwinmakt-20&linkCode=as2&camp=1789&creative=9325&creativeASIN=030746363X

It would be great if anyone can post a link to the 4-Hour Body's PAGG protocol.

4bf5827bfb7df85c5b4b485db0945e64

(1386)

on April 26, 2011
at 02:35 PM

Garlic and onions are not nightshades.

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on April 25, 2011
at 01:02 PM

It contains Glycoalkaloids just like a regular nightshade so it can exhibit molecular mimicry too. Onions the same way.

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on April 25, 2011
at 01:01 PM

Actually it is........

21fd060d0796fdb8a4a990441e08eae7

(24543)

on April 24, 2011
at 08:38 PM

Garlic is not a nightshade.

06d21b99c58283ce575e36c4ecd4a458

(9948)

on April 24, 2011
at 03:06 PM

Not sure where your Amazon link was susposed to go. The one I added is to Tim's book...The 4 hour body

06d21b99c58283ce575e36c4ecd4a458

(9948)

on April 24, 2011
at 03:06 PM

Not sure where your Amazon like was susposed to go. The one I added is to Tim's book...The 4 hour body.

8544465753d56e89bd1bb2c92e9cea7a

on April 24, 2011
at 06:09 AM

Policosanol: 20–25 mg Alpha-lipoic acid: 100–300 mg Green tea flavanols (at least 325 mg EGCG): 325 mg Garlic extract: 200 mg Prior to breakfast: AGG Prior to lunch: AGG Prior to dinner: AGG Prior to bed: PAGG

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5 Answers

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1
8544465753d56e89bd1bb2c92e9cea7a

on April 24, 2011
at 06:07 AM

I haven't tried the PAGG formula but one of the ingredients ALA (Alpha Lipoic Acid) has helped me keeping fat off. Whenever I cheat I take a 300mg of ALA with the meal.

PAGG is alpha lipoic acid, green tea extract, garlic extract and policosanol.

I'm copying the protocol from the book.

  • Policosanol: 20???25 mg
  • Alpha-lipoic acid: 100???300 mg
  • Green tea flavanols (decaffeinated with at least 325 mg EGCG): 325 mg
  • Garlic extract: 200 mg

Daily PAGG intake is timed before meals and bed, which produces a schedule like this:

  • Prior to breakfast: AGG
  • Prior to lunch: AGG
  • Prior to dinner: AGG
  • Prior to bed: PAGG

AGG is simply PAGG minus policosanol.

This dosing schedule is followed six days a week. Take one day o each week and one week off every two months. This week off is critical.

8544465753d56e89bd1bb2c92e9cea7a

on April 24, 2011
at 06:09 AM

Policosanol: 20–25 mg Alpha-lipoic acid: 100–300 mg Green tea flavanols (at least 325 mg EGCG): 325 mg Garlic extract: 200 mg Prior to breakfast: AGG Prior to lunch: AGG Prior to dinner: AGG Prior to bed: PAGG

3
6342765995f9abeac41445d4fee8ca3d

on April 24, 2011
at 02:30 PM

Actually garlic is an allium (like onions and leeks), not a nightshade.

2
Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on April 24, 2011
at 01:27 PM

P= Policosanol: 20???25 mg at night going to bed.

A= Alpha- lipoic acid: 100???300 mg (Tim takes 300 mg with each meal, but some people experience acid reflux symptoms with even 100 mg- so cut back if you need to)

G= Green tea flavanols (decaffeinated with at least 325 mg EGCG): 325 mg G= Garlic extract: at least 200 mg (Tim routinely uses 650+ mg) He writes in his blog

???Until further research concludes otherwise, I suggest using an aged-garlic extract (AGE) with high allicin potential that includes all constituent parts, including S-Allyl cysteine.

Published studies have come to conflicting conclusions regarding the efficacy of policosanol in lowering LDL (i.e., "bad cholesterol") or raising HDL (i.e., "good cholesterol"). Despite a number of studies funded by the Cuban government, which produces and markets the drug, independent clinical trials have found no evidence of the efficacy of policosanol.

Here are the studies..... ^ a b Heiner K. Berthold, MD, PhD; Susanne Unverdorben, MD; Ralf Degenhardt, PhD; Michael Bulitta, Dipl-Stat; Ioanna Gouni-Berthold, MD (May 17, 2006). "Effect of Policosanol on Lipid Levels Among Patients With Hypercholesterolemia or Combined Hyperlipidemia". Journal of the American Medical Association 295 (19): 2262???2269. doi:10.1001/jama.295.19.2262. PMID 16705107. Retrieved 2006-10-03. ^ Pons P, Rodriguez M, Robaina C, Illnait J, Mas R, Fernandez L, Fernandez JC. (1994). "Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment". International Journal of Clinical Pharmacology Research 14 (1): 27???33. PMID 7927958. ^ Chen JT, Wesley R, Shamburek RD, Pucino F, Csako G (2005). "Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol". Pharmacotherapy 25 (2): 171???83. doi:10.1592/phco.25.2.171.56942. PMID 15767233. ^ Thorsteinsd??ttir, Halla; S??enz, TW; Quach, U; Daar, AS; Singer, PA (2004). "Cuba???innovation through synergy". Nature Biotechnology 22 (12s): DC19???DC24. doi:10.1038/nbt1204supp-DC19. PMID 15583679.

The data on R alpha lipoic acid are pretty good for mitochondrial protection but PQQ NAC and tumeric seem in my view to be way better choices.

Allicin is great way to avoid MRSA infection and is quite good for you but if your strict paleo realize that garlic is a nightshade with glycoalkaloids.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on April 24, 2011
at 08:38 PM

Garlic is not a nightshade.

4bf5827bfb7df85c5b4b485db0945e64

(1386)

on April 26, 2011
at 02:35 PM

Garlic and onions are not nightshades.

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on April 25, 2011
at 01:01 PM

Actually it is........

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on April 25, 2011
at 01:02 PM

It contains Glycoalkaloids just like a regular nightshade so it can exhibit molecular mimicry too. Onions the same way.

1
1f24d4895246892ef4ee4d79b7f9eeeb

on April 24, 2011
at 03:17 PM

Ferris made an amendment to his recommendation on his blog after the book came out. He recommends taking the P only at bedtime, but not the green tea. So 3x a day, take AGG, and at bed, take PAG. I did this for 2 months with precious little difference. I am taking a month off to see if there is any difference.

0
5e36f73c3f95eb4ea13a009f4936449f

(8280)

on April 24, 2011
at 07:18 PM

As a caffeine whore, I found it very tough to switch from caffeine to PAGG alone. I had to winnow down the caffeine use as per the usual recommendations vs cold turkey.

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