2

votes

Fat and leptin: how does it work?

Answered on September 12, 2014
Created September 15, 2010 at 10:35 PM

http://diabetes.diabetesjournals.org/content/48/2/334.abstract What is the deal with this study? It shows that high-fat reduce leptin release? "Decreases of 24-h circulating leptin could contribute to the weight gain during consumption of high-fat diets. " This flies in the face of all my experience.

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on March 04, 2011
at 02:35 PM

This is not true. Amgen's data on its synthetic leptin drug has given us amazing insights to new research. Infact leptin appears to have major effects on synaptic signalling at the hypothalamus and restoring its receptors in formerly morbid obesity patients requires much higher levels of CSF leptin than we ever thought. That is why so many are intrigued with a set point possibility. Me personally I think that is too simplistic a mode for the hypothalamus because it is not plastic enough system to explain the diverse effects the human brain sees with respect to foods and diet.

4a1966b5bc00a9aefd3abd63b9913284

on September 22, 2010
at 09:58 PM

I've definitely found that a low carb diet curbs my appetite pretty well... too bad fruit just always sounds and looks (and IS!) so damned tasty! Grr!

62ed65f3596aa2f62fa1d58a0c09f8c3

(20807)

on September 16, 2010
at 04:43 AM

I suspect they don't yet understand how leptin works and certainly it does not work alone. A more accurate way to predict weight gain is to feed such a diet and look at actual body weight. Studies that actually did this did NOT find weight gain. They found weight loss. Therefore, fat does not cause weight gain. Even if it DOES reduce leptin release. Obvious answer is there are mediating factors, probably many of them, that we do not yet understand. Leptin is probably not just a simple on and off switch for eating. Leptin research on humans has yet to yield any decent weight loss.

62ed65f3596aa2f62fa1d58a0c09f8c3

(20807)

on September 16, 2010
at 04:36 AM

OK, this one may be a very good point. Low carb does not necesarily result in lessening hunger within the first 2 days. It's longer term that matters. At least give it a week for the body to adapt to the new foods!

62ed65f3596aa2f62fa1d58a0c09f8c3

(20807)

on September 16, 2010
at 04:34 AM

I can guarantee to you that in the big marjority of people, lowcarb drastically reduces hunger, paleo or no paleo. There are millions of lowcarbers that will tell you the same. I do not think the fact that the fat sources were not paleo is the issue here.

4a1966b5bc00a9aefd3abd63b9913284

on September 16, 2010
at 01:09 AM

I know, right?! Ew. It's everything that's wrong with the world... :( Well, except the turkey breast and tomato!

21fd060d0796fdb8a4a990441e08eae7

(24543)

on September 16, 2010
at 01:03 AM

I'm not sure if this is the case, but maybe switching abruptly to a high fat diet temporarily increases triglycerides, which contributes to temporary leptin resistance, which temporarily increases leptin secretion. Or I'm full of shit.

0bc6cbb653cdc5e82400f6da920f11eb

(19245)

on September 16, 2010
at 12:36 AM

It's not pointless, it adds to knowlage about leptin. If it indicates that a high fat junk food meal can cause people to eat too much I don't think anyone here would disagree.

07ca188c8dac3a17f629dd87198d2098

(7970)

on September 15, 2010
at 10:50 PM

Yuck, that meal set 1 looks horrid.

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7 Answers

3
149af6e19a06675614dfbb6838a7d7c0

on September 16, 2010
at 06:09 AM

I spoke with Dr. Ron Rosedale and he said that fat will reduce Leptin levels. You want low levels of Leptin. It works to decrease appetite not by increasing Leptin levels, but by decreasing leptin levels so that the cells can hear it. Just like increasing insulin is not the answer for diabetes, but getting the cells to hear insulin and hear leptin better is the answer. How do you get the cells to hear Leptin better, eat low carb (carbs raise insulin and leptin) eat less protein, (excess amino acids raise Leptin and insulin) eat MORE fat. Fat lowers Leptin and will lower Insulin.

3
4a1966b5bc00a9aefd3abd63b9913284

on September 15, 2010
at 10:47 PM

Not that this entirely answers your question, but it's always important to look at the study design. Check out the foods included in the High-Fat/Low-Carb diet... to me, the use of neolithic foods at all will skew this data from what we know to happen as a result of the consumption of high fat/low carb vs high carb/low fat.

HF/LC meals: Meal Set 1 Whole wheat bread, Turkey breast, Iceberg lettuce, Tomato, Whole milk , Margarine, Canola oil, Mayonnaise, American cheese

Meal Set 2 Whole wheat bread, Turkey breast, Egg yolk, Egg white, Cheddar cheese, Butter, Half and half cream

Just my 2 cents.

07ca188c8dac3a17f629dd87198d2098

(7970)

on September 15, 2010
at 10:50 PM

Yuck, that meal set 1 looks horrid.

4a1966b5bc00a9aefd3abd63b9913284

on September 16, 2010
at 01:09 AM

I know, right?! Ew. It's everything that's wrong with the world... :( Well, except the turkey breast and tomato!

62ed65f3596aa2f62fa1d58a0c09f8c3

(20807)

on September 16, 2010
at 04:34 AM

I can guarantee to you that in the big marjority of people, lowcarb drastically reduces hunger, paleo or no paleo. There are millions of lowcarbers that will tell you the same. I do not think the fact that the fat sources were not paleo is the issue here.

4a1966b5bc00a9aefd3abd63b9913284

on September 22, 2010
at 09:58 PM

I've definitely found that a low carb diet curbs my appetite pretty well... too bad fruit just always sounds and looks (and IS!) so damned tasty! Grr!

1
21fd060d0796fdb8a4a990441e08eae7

(24543)

on September 16, 2010
at 12:56 AM

Check it out dude, there's a clue in the discussion section:

"Furthermore, when fat or carbohydrate is fed in excess of energy requirements for 14 days, a greater amount of the surplus energy from fat (90???95%) is stored than from carbohydrate (75???85%). These results suggest that increasing dietary carbohydrate content alters the regulated level of adiposity by increasing energy expenditure or altering nutrient partitioning. These effects could be mediated by increased leptin production..."

"The increased leptin concentrations with high-carbohydrate feeding may result from an effect of insulin and glucose excursions after high-carbohydrate meals to increase glucose uptake and metabolism in adipose tissue, since glucose utilization has recently been shown to have a major influence on leptin gene expression and on leptin secretion from adipocytes in vitro."

My interpretation: the subjects were changed from their normal diets to either a high or low carb diet. Leptin response in those two days depends on the meals in those two days, and the response may differ if such a diet is continued. Note that Romon 2003 had an opposite finding: "In obese subjects, as in lean subjects, postprandial leptin response, calculated as the increment above fasting values, was higher after the carbohydrate meal than after the fatty meal."

21fd060d0796fdb8a4a990441e08eae7

(24543)

on September 16, 2010
at 01:03 AM

I'm not sure if this is the case, but maybe switching abruptly to a high fat diet temporarily increases triglycerides, which contributes to temporary leptin resistance, which temporarily increases leptin secretion. Or I'm full of shit.

1
0bc6cbb653cdc5e82400f6da920f11eb

(19245)

on September 16, 2010
at 12:33 AM

It's just science in progress.

Leptin is a quite a recent hormone and it will take a lot more research to understand it more fully. It can't be understood by looking at each new small study in tern without a great deal of confusion.

1
8e3782b68e033763485472f414f507a5

(2433)

on September 15, 2010
at 10:57 PM

A two-day study is pretty pointless. These people may have all been eating high-carb their entire lives, and therefore could have put their bodies into a state of shock by suddenly switching to high-fat.

Incidentally, people who are overweight tend to have high leptin levels because they are leptin resistent. Giving them more leptin accomplishes nothing.

0bc6cbb653cdc5e82400f6da920f11eb

(19245)

on September 16, 2010
at 12:36 AM

It's not pointless, it adds to knowlage about leptin. If it indicates that a high fat junk food meal can cause people to eat too much I don't think anyone here would disagree.

62ed65f3596aa2f62fa1d58a0c09f8c3

(20807)

on September 16, 2010
at 04:36 AM

OK, this one may be a very good point. Low carb does not necesarily result in lessening hunger within the first 2 days. It's longer term that matters. At least give it a week for the body to adapt to the new foods!

1
07ca188c8dac3a17f629dd87198d2098

(7970)

on September 15, 2010
at 10:49 PM

As with any study, I'd get in the habit of substituting the word "suggests" in place of "shows" or "proves", and add a "may" or "might".

Having said that, I think I've heard that over time leptin response is indeed decreased over time, and an occasional carb re-feed might help reset this. Naturally we'd want to stick to our acceptable carbs, e.g. sweet potatoes.

0
9d43f6873107e17ca4d1a5055aa7a2ad

on September 15, 2010
at 10:53 PM

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