7

votes

Anything like a 'First In Last Out' effect w/ fat cells?

Answered on August 19, 2014
Created June 07, 2011 at 12:03 AM

A question for the science wizards here: are our fat cells equally dynamic in that fatty acids are transported in and out pretty democratically throughout the adipose tissue, or is there a kind of 'walling off' and layering with older cells being shoved to the back closet and only processed when all the fat accumulated since is processed first?

Or, said another way, does our fat contain a kind of history of our dietary lives, and does losing that fat happen all at once or in reverse order to its accumulation?

I've had this feeling that as I lost a chunk of weight that I was facing certain issues from the past. For instance, about 10 years ago I weighed about 170 lbs, and was dealing with an anemia diagnosis. Now that I'm approaching 170 again from the opposite direction, anemia has again surfaced as a concern (although the actual condition has probably been unchanged the whole time). I also had quit coffee for a while around that time - and suddenly I'm considering quitting coffee again.

My examples are more mental, but my question is also about toxins or chemicals stored in the fat - if, say, I ever get below 150 (not my plan) would I suddenly be experiencing nicotine issues since I quit at about that weight? Or is that 'history' long gone from my body?

Weird question I know - and perhaps not entirely "paleo" - maybe I should be asking it on the Outer Limits Hacks site??

1398eff69b192c35de5e0dbaad59052a

(2024)

on June 07, 2011
at 06:18 PM

I asked my naturopath if there was anything to a detox, and she kind of shrugged her shoulders and said, "Healing crisis? Herxheimer's reaction? We just don't know. There very well could be, though."

Fe29f6658ce67c1ecc4a22e960be7498

(2997)

on June 07, 2011
at 01:15 PM

Yeah - sounds like a similar idea.

Fe29f6658ce67c1ecc4a22e960be7498

(2997)

on June 07, 2011
at 01:14 PM

Haha - I'd donate them to keep the SMELL away!

Fe29f6658ce67c1ecc4a22e960be7498

(2997)

on June 07, 2011
at 05:25 AM

Interesting - is there a layman's overview available?

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on June 07, 2011
at 12:45 AM

Fat labeling studies show fat can be added and broken down right away and other fat can stay for decades and never get touched.

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on June 07, 2011
at 12:44 AM

depends upon the levels of aromatase in the adipocyte and the sex steroids in the nucleus of the fat cell. The real interesting fat is the last twenty pounds. That fat is handled very differently.

Fe29f6658ce67c1ecc4a22e960be7498

(2997)

on June 07, 2011
at 12:15 AM

Yeah that's the physical placement - what about the content of those fat cells? Are they 'visited' by the blood stream as regularly as newer cells, or are they just skeletons in the closet until the new stuff is cleared out first?

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3 Answers

2
Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on June 07, 2011
at 12:08 AM

It is a good question and its not first in and first out.....your hormone status determines first where The fat goes and where it comes from initially......that is under the control of LPL and Hormone sensitive lipase. That is why belly and ass and hip fat is hard to lose when you are not optimized hormonally

Fe29f6658ce67c1ecc4a22e960be7498

(2997)

on June 07, 2011
at 05:25 AM

Interesting - is there a layman's overview available?

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on June 07, 2011
at 12:44 AM

depends upon the levels of aromatase in the adipocyte and the sex steroids in the nucleus of the fat cell. The real interesting fat is the last twenty pounds. That fat is handled very differently.

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on June 07, 2011
at 12:45 AM

Fat labeling studies show fat can be added and broken down right away and other fat can stay for decades and never get touched.

Fe29f6658ce67c1ecc4a22e960be7498

(2997)

on June 07, 2011
at 12:15 AM

Yeah that's the physical placement - what about the content of those fat cells? Are they 'visited' by the blood stream as regularly as newer cells, or are they just skeletons in the closet until the new stuff is cleared out first?

1
1398eff69b192c35de5e0dbaad59052a

(2024)

on June 07, 2011
at 07:26 AM

I've wondered about this too. All these people talk about "retracing" in a detox, and I have no idea whether there's anything to it, or not. Not a lot of scientific evidence, but there's a lot we just don't know about.

1398eff69b192c35de5e0dbaad59052a

(2024)

on June 07, 2011
at 06:18 PM

I asked my naturopath if there was anything to a detox, and she kind of shrugged her shoulders and said, "Healing crisis? Herxheimer's reaction? We just don't know. There very well could be, though."

Fe29f6658ce67c1ecc4a22e960be7498

(2997)

on June 07, 2011
at 01:15 PM

Yeah - sounds like a similar idea.

0
1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on June 07, 2011
at 05:53 AM

I say you are done with smoking :-)

However if you still have your old clothes from that time I would doante them to keep the memories away...

Fe29f6658ce67c1ecc4a22e960be7498

(2997)

on June 07, 2011
at 01:14 PM

Haha - I'd donate them to keep the SMELL away!

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