One hormone but Different Functioning inside cell and in blood serum?

Answered on August 19, 2014
Created September 04, 2012 at 10:14 PM

IGF_1(insulin-like growth factor) has positive anabolic effects as well as causing some cancer. Adding protein in low carb increases IGF_1 inside muscle cells with positive anabolic signalling, while reducing IGF_1 in blood serum reducing negative effects of cancer. (see nice answer by RawNut in "Protein and IGF_1" and reference

Question 1: What are examples of hormone with both positive and negative effects in different locations of body other than IGF_1?

Question 2: Other than food intake, does exercises affect the differentiation of concentration of these hormones in different parts of body?(like BDNF(brain derived neurotrophic factor) produced by exercises helping nerve growth ).

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3 Answers


on February 24, 2013
at 04:44 AM

This doesn't make any sense... IGF-1 is a hydrophilic molecule and is a ligand for cell surface receptors NOT a hydrophobic transcription factor that can directly diffuse through cell membranes...so to be honest, what are you talking about regarding intracellular IGF-1 levels? you can't even measure that unless u perform immunocytochemistry. it's not just something u measure with serum blood levels... btw, everyone thinks anabolic means building muscle...well it also means...storing fat, building glycogen, moving glucose into cells, building intracellular cytoskeleton parts, building proteins for cell division in a random ass gastric paneth cell. so uh, yes eating low carb esp in a newly adjusting individual will lead to lower glucose levels -> GH release -> IGF-1 production -> IGF-1 mediated cell signaling -> anabolic consequences. that doesn't mean ur building muscle though...

of course cancer cells may exhibit elevated IGF-1 SIGNALING (mainly AKT signaling)... any cell growth or proliferation promoting pathway is almost certainly overactive in cancer cells. but just because it is overactive doesn't mean it caused cancer...

basically, i'm a little frustrated with the ridiculous oversimplification and inaccuracy of your statements


on February 24, 2013
at 12:19 AM

I'm pretty sure that you need to actually work out and tear the muscle fibers for them to rebuild. Case in point ive been low carb for a while and havn't not gained any muscle, I don't workout.

Q1: Estrogen can have positive and negative affects. Many cells have estrogen receptors and different cells have different affinities to these receptors.


on September 04, 2012
at 10:18 PM

Doesn't DHT exist in hair follicles? Therefore DHT on certain parts of your body contributes to prostate issues, hair loss on the head and hair growth elsewhere.

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