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High Free Estradiol, what to do to lower?

Answered on August 19, 2014
Created May 13, 2013 at 9:40 PM

My free estradiol value was .46. My total estradiol was 17. So my free estradiol was above the reference range.
Any advice on decreasing it? I would like to get it to the bottom of the reference range. I also take DHEA, so maybe some is converting to estradiol at a high rate.

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on July 03, 2013
at 12:22 PM

Picolinate is supposed to be one of the most bio available forms.

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on July 03, 2013
at 02:49 AM

It was glycinate btw

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on July 03, 2013
at 02:18 AM

You have any particular zinc forms that are best?

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on July 03, 2013
at 02:16 AM

Was only running previously, now am lifting. Started taking DIM, but I am a bit concerned about its antiandrogenic effects...

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 11:22 PM

Lol thegiantess.

06bf7b92d77f1ac1d8e3dc9d539d8254

(1649)

on May 14, 2013
at 09:17 PM

You just blew my mind about the Zinc gluconate thing. Seriously. Why have I even bothered?

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:19 PM

20% that is ,

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:18 PM

You need to find the molar mass of the chelate they use whether that was gluconate, picolinate or something else, the molar mass of zinc is 65g about. Divide 65 by the molar mass of the chelate+the zinc to find out what percent of it is actually elemental zinc and would fall under the RDA's guidelines. I'm willing to bet it's only 14-40%. Picolinate is around 20 I think.

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on May 14, 2013
at 02:53 AM

well technically it was 22 mg of chelated zinc, im not sure if that equates to elemental zinc. You do bring up a good point

1c67bc28f4e44bbb8770b86df0463df3

(6719)

on May 14, 2013
at 12:52 AM

diet/stats/workout?? Your not consuming soy in any form... are you?

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:13 AM

I just think of copper as friends with estrogen and zinc as friends with testosterone. That's probably oversimplified but there seems to be a lot of data to support the loose correlation. If you want I'll root some up and post it here.

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:11 AM

I do find it strange though that your copper was low, but it'd be extraordinarily unlikely you'd be getting a copper deficiency from 4.2 g of elemental zinc, that doesn't happen until like, 150g or so per day from what I recall. (I'd personally never risk supplementing over 40g of elemental zinc per day, and if I was going to do it for prolonged periods, probably even less than that).

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:08 AM

Hmm, I'm still suspicious of low zinc levels. Were you taking 30mg of zinc gluconate? You know that that stuff is only 14% zinc by weight so that 30 mgs of zinc gluconate is something like 4.2 grams of elemental zinc (about 1/2-1/3rd of the rda for zinc and well below the safe upper limit which is somewhere around 40? I think.) The amount of zinc you were supplementing is equivalent to about 2 oz of steak: http://nutritiondata.self.com/facts/beef-products/3820/2 .

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on May 13, 2013
at 10:56 PM

yea i thought about that, i typically take 30 mgs per day as is. my copper was actually fairly low so i stopped zinc supplementation for the most part

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1 Answers

1
Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 13, 2013
at 09:54 PM

Zinc supplementation, have you had your copper levels checked? 10:1 says they're also too high.

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:13 AM

I just think of copper as friends with estrogen and zinc as friends with testosterone. That's probably oversimplified but there seems to be a lot of data to support the loose correlation. If you want I'll root some up and post it here.

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:18 PM

You need to find the molar mass of the chelate they use whether that was gluconate, picolinate or something else, the molar mass of zinc is 65g about. Divide 65 by the molar mass of the chelate+the zinc to find out what percent of it is actually elemental zinc and would fall under the RDA's guidelines. I'm willing to bet it's only 14-40%. Picolinate is around 20 I think.

06bf7b92d77f1ac1d8e3dc9d539d8254

(1649)

on May 14, 2013
at 09:17 PM

You just blew my mind about the Zinc gluconate thing. Seriously. Why have I even bothered?

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on May 14, 2013
at 02:53 AM

well technically it was 22 mg of chelated zinc, im not sure if that equates to elemental zinc. You do bring up a good point

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 11:22 PM

Lol thegiantess.

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on May 13, 2013
at 10:56 PM

yea i thought about that, i typically take 30 mgs per day as is. my copper was actually fairly low so i stopped zinc supplementation for the most part

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:11 AM

I do find it strange though that your copper was low, but it'd be extraordinarily unlikely you'd be getting a copper deficiency from 4.2 g of elemental zinc, that doesn't happen until like, 150g or so per day from what I recall. (I'd personally never risk supplementing over 40g of elemental zinc per day, and if I was going to do it for prolonged periods, probably even less than that).

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:19 PM

20% that is ,

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on May 14, 2013
at 12:08 AM

Hmm, I'm still suspicious of low zinc levels. Were you taking 30mg of zinc gluconate? You know that that stuff is only 14% zinc by weight so that 30 mgs of zinc gluconate is something like 4.2 grams of elemental zinc (about 1/2-1/3rd of the rda for zinc and well below the safe upper limit which is somewhere around 40? I think.) The amount of zinc you were supplementing is equivalent to about 2 oz of steak: http://nutritiondata.self.com/facts/beef-products/3820/2 .

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on July 03, 2013
at 02:49 AM

It was glycinate btw

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on July 03, 2013
at 12:22 PM

Picolinate is supposed to be one of the most bio available forms.

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on July 03, 2013
at 02:18 AM

You have any particular zinc forms that are best?

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