8

votes

NSAIDS: Ibuprofen, Paracetamol, Aspirin

Answered on August 19, 2014
Created July 29, 2011 at 1:45 PM

Usually, I try to avoid using chemical drugs (NSAIDS included) unless it's really necessary. But sometimes you have to take them when you catch a virus, etc.

So, the questions if which one of them is less harmful, has less side-effects? I'm talking about occasional use in case of sickness not regular usage.

Thank you very much!

Medium avatar

(115)

on December 27, 2012
at 05:48 PM

Yes, and I can find thousands of people who recommend statins. However stone age people rarely ate willowbark I would guess. Especially strongly processed such substance. Aspirin is definitely the substance toughest for your stomach, increasing likelihood for ulcers, but less hard for the liver.

Medium avatar

(115)

on December 27, 2012
at 05:42 PM

"But sometimes you have to take them when you catch a virus, etc" No, you never HAVE to take them. But you may feel you NEED to take them. But that obviously isn't very paleo.

B9cc28905ec54389c47cde031d709703

on October 14, 2011
at 11:30 AM

Also been in use for 100+ years.

F1b39d4f620876330312f4925bd51900

(4090)

on August 01, 2011
at 05:50 PM

Thanks Quilt, I will give that a try! Fish oil didn't help my tummy troubles in the slightest but if it will help with migraines and cramps I will be trying it again. (But just on those occasions).

3c6b4eed18dc57f746755b698426e7c8

(5147)

on July 31, 2011
at 07:29 PM

do you remember the dose? I try not to take more than 500mg per day when I have a gout/RA attack. the alnterantive is to suffer through the attack for a day or two, which is not really acceptable.

21fd060d0796fdb8a4a990441e08eae7

(24543)

on July 31, 2011
at 06:00 AM

Source? One fish oil capsule does not have the same acute anti-inflammatory effect as two advils, or so I thought. I've never seen anything in the literature suggesting otherwise.

77877f762c40637911396daa19b53094

(78467)

on July 30, 2011
at 08:31 PM

Please be very careful with Naproxen. That's what I was given for sciatica and back pain. Some side effects are hearing loss and tinnitus. Guess what I have now - hearing loss and tinnitus. I told this to another doctor who wanted to prescribe Naproxen so I told him about this and he said, 'Oh, really? I didn't know that." There are better ways to treat back and sciatica.

559aa134ff5e6c8bcd608ba8dc505628

(3631)

on July 30, 2011
at 06:34 PM

e.g. http://www.sciencedirect.com/science/article/pii/S0140673684927399

559aa134ff5e6c8bcd608ba8dc505628

(3631)

on July 30, 2011
at 06:33 PM

i stopped taking it, myself. i think it's counterproductive for auto-immune stuff b/c it increases intestinal permeability. but if i were in severe pain daily it would be much harder to say no.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on July 30, 2011
at 05:08 PM

No, for my gout/RA.

6120c989fd5b69f42a0834b69b87955b

(24553)

on July 30, 2011
at 05:21 AM

For some reason my cramps disappeared when I started consuming a green powder supplement most days (I use Vitamineral Green, but I'm guessing any concentrated green juice would work), and they had previously been on par with labor pains. Don't know why exactly, but I'm not complaining.

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on July 30, 2011
at 04:35 AM

What is it for (backpain)? You need to dring a very nice glass of water when you take it?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on July 30, 2011
at 03:40 AM

i never use em......they cause a leaky gut 100% of the time.

F1b39d4f620876330312f4925bd51900

(4090)

on July 29, 2011
at 07:57 PM

If taking some magnesium can take the place of two advil, sign me up. Pot! If I did that I would gorge on honey and raisins!! haha!

612c09622d41fa959953aae0c8ee86c8

(90)

on July 29, 2011
at 06:58 PM

Magnesium for when you are work, pot when you are off!

F1b39d4f620876330312f4925bd51900

(4090)

on July 29, 2011
at 06:14 PM

That is hilarious! I would feel so bloated and fat with that in my pants, but it was a great idea all the same!!

9d43f6873107e17ca4d1a5055aa7a2ad

on July 29, 2011
at 06:01 PM

you should try the stick-on mini heating pads. http://www.amazon.com/Thermacare-Wraps-Menstrual-Cramp-Relief/dp/B002L24BDM/

9d43f6873107e17ca4d1a5055aa7a2ad

on July 29, 2011
at 05:51 PM

I have a genetic variant that makes me more susceptible to ulcers from NSAIDs. That makes sense, because when I was younger I took them all the time for headaches and I had several ulcers before I was 19. These days I take Tylenol, but only if the pain is so bad I can't sleep. This happens maybe once or twice a year and I take a single Tylenol. It's amazing how sensitive you become to these things if you almost never take them.

34a367e60db77270bd7096dc04270fdc

(4171)

on July 29, 2011
at 04:47 PM

Thank you Eric - I had no idea it was that toxic. I only take Tylenol maybe once a day and I rarely drink so don't have any liver damage from alcohol but I'll probably stay away from the Tylenol as much as possible now.

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on July 29, 2011
at 02:07 PM

I have updated my response with an article fron Dr. Harris. I lost my aunt to tylenol many years ago

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on July 29, 2011
at 01:58 PM

I have updated ny response with an article fron Dr. Harris. I lost my aunt to tylenol many years ago...

34a367e60db77270bd7096dc04270fdc

(4171)

on July 29, 2011
at 01:55 PM

Really? I would have guessed that Ibuprofen (NSAIDS) would be worse. I have a perscription NSAID for pain caused by connective tissue disease but I often opt to take Tylenol instead thinking it was better than the other. Can you elaborate on your opinion at all?

  • B121fdbc1aaa6130f5bda3bf84e3ba2d

    asked by

    (952)
  • Views
    6.5K
  • Last Activity
    1282D AGO
Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

12 Answers

6
4145b36f1488224964edac6258b75aff

(7821)

on July 29, 2011
at 02:02 PM

Tylenol is toxic to your liver in surprisingly low doses, especially in combination with alcohol. It's actually one of the most common causes of poisoning in the world: http://en.wikipedia.org/wiki/Paracetamol_toxicity

Of course, long term NSAID use can destroy your guts: http://en.wikipedia.org/wiki/Non-steroidal_anti-inflammatory_drug

The solution? If you're going to use either drug, use the minimum dosage necessary for the minimum time necessary. The dose makes the poison, so keep your dose to the minimum and you'll never have to worry about the above issues.

4
36b7a2776d028dc8d5743e2e56ece34d

on July 29, 2011
at 01:51 PM

Ray peat think aspirin is the best option and even thinks it may have some health benefits.

http://raypeat.com/articles/aging/aspirin-brain-cancer.shtml

B9cc28905ec54389c47cde031d709703

on October 14, 2011
at 11:30 AM

Also been in use for 100+ years.

Medium avatar

(115)

on December 27, 2012
at 05:48 PM

Yes, and I can find thousands of people who recommend statins. However stone age people rarely ate willowbark I would guess. Especially strongly processed such substance. Aspirin is definitely the substance toughest for your stomach, increasing likelihood for ulcers, but less hard for the liver.

2
1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on July 29, 2011
at 01:52 PM

Avoid Tylenol. It is very hard on the body.

From Dr. Harris

http://www.psychologytoday.com/blog/p-nu/201103/tylenol-and-the-war-drugs

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on July 29, 2011
at 01:58 PM

I have updated ny response with an article fron Dr. Harris. I lost my aunt to tylenol many years ago...

34a367e60db77270bd7096dc04270fdc

(4171)

on July 29, 2011
at 01:55 PM

Really? I would have guessed that Ibuprofen (NSAIDS) would be worse. I have a perscription NSAID for pain caused by connective tissue disease but I often opt to take Tylenol instead thinking it was better than the other. Can you elaborate on your opinion at all?

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on July 29, 2011
at 02:07 PM

I have updated my response with an article fron Dr. Harris. I lost my aunt to tylenol many years ago

34a367e60db77270bd7096dc04270fdc

(4171)

on July 29, 2011
at 04:47 PM

Thank you Eric - I had no idea it was that toxic. I only take Tylenol maybe once a day and I rarely drink so don't have any liver damage from alcohol but I'll probably stay away from the Tylenol as much as possible now.

9d43f6873107e17ca4d1a5055aa7a2ad

on July 29, 2011
at 05:51 PM

I have a genetic variant that makes me more susceptible to ulcers from NSAIDs. That makes sense, because when I was younger I took them all the time for headaches and I had several ulcers before I was 19. These days I take Tylenol, but only if the pain is so bad I can't sleep. This happens maybe once or twice a year and I take a single Tylenol. It's amazing how sensitive you become to these things if you almost never take them.

1
Cbda678b2a6bf0537d8c4ea0ce8aa9ad

(4319)

on July 30, 2011
at 04:58 AM

Menstrual issues: A lady friend of mine swears by an herbal product called "Cramp Releaf". She says the tincture is more effective than the pills. I am a male, so never tried.

1
26b7615ef542394102785a67a2786867

on July 29, 2011
at 11:41 PM

Advil FTW. I still have menstrual cramps one day per month, and occasional headaches and muscle pain (I have had problems all my life with anxiety-caused back and neck tightness and pain). Aspirin does nothing to effect pain or inflammation, Tylenol scares me too much to use (not that I would ever take enough to OD, since I'm the size of a 12-year-old I take low doses of all meds, but I've heard from doctors that combining Tylenol and alcohol in your liver is a disastrously bad idea, and I like to be able to have a drink now and then..)

1
F1b39d4f620876330312f4925bd51900

(4090)

on July 29, 2011
at 05:59 PM

Anyone know any pain reliever alternatives? Being a women, cramps come once a month, pain relievers are a must. (I often hear..lay down with a heating pad..ya that really works when I am at work all day, or have a life). Tylenol has no effect on pain for me, so I take advil. Since I have big time tummy troubles, it would be good to find an alternative.

F1b39d4f620876330312f4925bd51900

(4090)

on July 29, 2011
at 07:57 PM

If taking some magnesium can take the place of two advil, sign me up. Pot! If I did that I would gorge on honey and raisins!! haha!

F1b39d4f620876330312f4925bd51900

(4090)

on July 29, 2011
at 06:14 PM

That is hilarious! I would feel so bloated and fat with that in my pants, but it was a great idea all the same!!

9d43f6873107e17ca4d1a5055aa7a2ad

on July 29, 2011
at 06:01 PM

you should try the stick-on mini heating pads. http://www.amazon.com/Thermacare-Wraps-Menstrual-Cramp-Relief/dp/B002L24BDM/

612c09622d41fa959953aae0c8ee86c8

(90)

on July 29, 2011
at 06:58 PM

Magnesium for when you are work, pot when you are off!

6120c989fd5b69f42a0834b69b87955b

(24553)

on July 30, 2011
at 05:21 AM

For some reason my cramps disappeared when I started consuming a green powder supplement most days (I use Vitamineral Green, but I'm guessing any concentrated green juice would work), and they had previously been on par with labor pains. Don't know why exactly, but I'm not complaining.

1
6120c989fd5b69f42a0834b69b87955b

(24553)

on July 29, 2011
at 05:32 PM

I thought this link had a lot of useful ideas for mitigating damage that could occur from either acetaminophen and NSAIDs: http://www.lef.org/protocols/appendix/otc_toxicity_01.htm

Either one can reduce glutathione levels, and that can be offset by supplemental antioxidants like NAC (N-Acetyl-Cysteine).

I don't know if you have access to a naturopath, but my ND made me an anti-inflammatory tincture when I had a nasty viral infection that was causing significant bone and muscle pain. I don't know what was in it, but it worked better than the ibuprofen I had been taking to cope for the days leading up to the appointment.

1
3c6b4eed18dc57f746755b698426e7c8

on July 29, 2011
at 03:57 PM

What do people think about Naproxen? At a dose of say 375mg to 500mg per day?

3c6b4eed18dc57f746755b698426e7c8

(5147)

on July 30, 2011
at 05:08 PM

No, for my gout/RA.

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on July 30, 2011
at 04:35 AM

What is it for (backpain)? You need to dring a very nice glass of water when you take it?

559aa134ff5e6c8bcd608ba8dc505628

(3631)

on July 30, 2011
at 06:34 PM

e.g. http://www.sciencedirect.com/science/article/pii/S0140673684927399

3c6b4eed18dc57f746755b698426e7c8

(5147)

on July 31, 2011
at 07:29 PM

do you remember the dose? I try not to take more than 500mg per day when I have a gout/RA attack. the alnterantive is to suffer through the attack for a day or two, which is not really acceptable.

559aa134ff5e6c8bcd608ba8dc505628

(3631)

on July 30, 2011
at 06:33 PM

i stopped taking it, myself. i think it's counterproductive for auto-immune stuff b/c it increases intestinal permeability. but if i were in severe pain daily it would be much harder to say no.

77877f762c40637911396daa19b53094

(78467)

on July 30, 2011
at 08:31 PM

Please be very careful with Naproxen. That's what I was given for sciatica and back pain. Some side effects are hearing loss and tinnitus. Guess what I have now - hearing loss and tinnitus. I told this to another doctor who wanted to prescribe Naproxen so I told him about this and he said, 'Oh, really? I didn't know that." There are better ways to treat back and sciatica.

0
32f5749fa6cf7adbeb0b0b031ba82b46

(41757)

on October 14, 2011
at 01:30 PM

Use the drug of choice that you find the most effective. You minimize your dose that way. APAP (Tylenol) is pretty hard on your liver as others have pointed out. Ibuprofen/Naproxen is hard on your digestive tract. Asparin can be hard on your stomach (if you're sensitive).

Personally, I find aspirin is very effective for 75+% of what ails me (not sensitive to it). Ibuprofen covers another 20% or so. Then a good dose a K and/or Mg will fix the remaining problems. APAP has zero effect on me. Naproxen doesn't do much either.

0
77877f762c40637911396daa19b53094

(78467)

on October 14, 2011
at 11:25 AM

I use codeine as painkiller once in year or so, when huge Mg, Zn and fish oil dose don't help.

Chronic NSIADs are very dangerous. I am sure you all know about Viox scandal.

Also, check out the study Iatrogenic effects of COX-2 inhibitors in the US population: findings from the Medical Expenditure Panel Survey which concluded:

Iatrogenic effects of coxibs in the US population were substantial, posing an important public health risk. Drugs that were rapidly accepted for assumed safety advantages proved instead to have caused substantial injury and death

There is also "Analgesic Use and the Risk of Hearing Loss in Men" which says

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.

Furthermore, diclofenac is responsible for removal of entire specie from planet Earth:

Use of diclofenac in animals has been reported to have led to a sharp decline in the vulture population in the Indian subcontinent, 95% decline in 2003, 99.9% decline as of 2008 .... . Associated with the rise in dog numbers is an increased risk of rabies" and casualties of almost 50,000 people ... Diclofenac has been shown also to harm freshwater fish species such as rainbow trout.

0
Ffc7e0ecad8e8831b528c5d4921377cc

(942)

on July 31, 2011
at 04:49 AM

I try to avoid any painkillers. However, I take baby aspirin several times a week. From what I've read, it helps prevent heart attacks, strokes, colon cancer and pancreatic cancer. Any one of those would be plenty of reason to take it.

I and my family have a history of heart trouble. Strokes destroy part of who you are. Family history of colon cancer. Pancreatic cancer is nearly always quickly and painfully fatal.

So, I'll live with the downside of aspirin, while, of course, counting on Paleo to help prevent the above diseases too.

0
Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on July 30, 2011
at 06:21 PM

One gel tablet RX grade Fish oil has the same anti inflammatory efficacy as two advil's. That is what I tell my patients to use in place of NSAID's. Fish oil does not cause a leaky gut while all members of the NSAID class do. I treat aspirin a bit differently because it is an uncoupler of oxidative phosphorylation in the mitochondria so as one passes 35 yrs old you can make an argument for its use.

Major side effect of fish oil in high doses is bleeding and elevation of your cholesterol if you really care about your cholesterol.

F1b39d4f620876330312f4925bd51900

(4090)

on August 01, 2011
at 05:50 PM

Thanks Quilt, I will give that a try! Fish oil didn't help my tummy troubles in the slightest but if it will help with migraines and cramps I will be trying it again. (But just on those occasions).

21fd060d0796fdb8a4a990441e08eae7

(24543)

on July 31, 2011
at 06:00 AM

Source? One fish oil capsule does not have the same acute anti-inflammatory effect as two advils, or so I thought. I've never seen anything in the literature suggesting otherwise.

Answer Question


Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!