How would you go about up-regulating sex hormones, androgen receptors and dopamine all while down-regulating estrogen receptors and prolactin?

Answered on February 01, 2016
Created June 25, 2013 at 2:49 PM

Take something like testosterone for example. Testosterone therapy will drop bodyfat, increase Lean body mass, Improve insulin sensitivity, increase sex drive, and if you're a wall street analysis it will predict how much money you make THAT DAY.

Attractiveness is predicted by sex hormones in both men and women. Attractive people are more likely to get a job if they have the same qualifications or even slightly worse than their competition. Attractive people get paid more, Have stronger immune systems, are smarter and are happier.

It might seem then that fertility or virility is probably tied to one's overall well-being and how happy of a life you lead. Are we focusing on the wrong things then by nitpicking over semantics in our diets when the bigger picture is that we need to up-regulate our sex hormones?

I didn't get to in depth with the hormones here, but some other interesting facts are that testosterone and dopamine are positively correlated with each other and inversely correlated with insulin resistance and prolactin. Boosting your insulin sensitivity, testosterone and dopamine all seem to go hand in hand working together to promote health and counteract stress. If you have high dopamine you literally cannot have high prolactin too at the same time.



on October 31, 2015
at 07:18 AM

take testerone and and estrogen blocker



on July 03, 2013
at 01:36 AM

Hands Down 3 should be arriving soon, it'll be epicness in a post.



on June 25, 2013
at 03:23 PM

A good answer to this question would probably be especially valuable to you CD, considering your position where you work. This is a different question than I had asked last time, and they are both poorly worded imo. I'm essentially trying to take a broad stroke to see if anyone else here has some ideas on the subject as I work up to a Ultimate Hacks Part 3 to complete the trilogy, get my 10k points and retire from PH, lol..



on June 25, 2013
at 03:06 PM

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2 Answers



on February 01, 2016
at 03:39 PM

A few things can help.  Check your DHEA levels via blood test, if they're low you can supplement with it, but DHEA is a precursor to both estrogens and testosterone - or if your stress levels are high, it could be used to make cortisol.  So you'd need something else as well, tribulus, tongkatali, and/or pine pollen are known to stimulate testosterone production without exogenous injections.

But a better substrate than DHEA is good old cholesterol.  You'd increase levels of this by consuming clean sources of saturated fats (grassfed beef fat/butter, pastured pork, egg yolks, etc.)  Cholesterol is the substrated used to make DHEA and most other hormones.  Make sure your HDL is high and keep it high. Asprey's Get Some Ice Cream is a good example.

You'll want to ensure you've got high enough levels of zinc, magnesium, selenium, and iodine. (The last two are more for your thyroid, but that's often helpful, unless you've got an autoimmune thyroid disease.) So things like shellfish (clams, oysters, mussels) are useful here.

Increasing skeletal muscle mass and tone is also important because you need to dispose of testosterone properly, else it turns into DHT causing hair loss, or perhaps if you've got too much fat in storage, it will turn into estrodiol via aromatase.  So something to block aromatase is useful, but beware of DIM, it can interfere with mitochondrial function, so it's not ideal.  Perhaps calcium D-Glucarate is better.


on January 29, 2016
at 07:45 PM

Hi Stephen_4,

Regarding hormones: ie. balancing testosterone/estrogen/progesterone and keeping prolactin low and dopamine high... I would like to suggest looking in to progesterone supplementation. It must be USP progesterone, not synthetic, as it is the same molecule the body makes.

Please check out Wray White's site, progesteronetherapy.org.

I have been using it for months and have seen great results and have an increased sense of well-being.

Best regards

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