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VDR Taq +/+ - does this mean I need to supplement D3?

Commented on February 23, 2014
Created February 22, 2014 at 9:35 PM

I finally got my DNA results via ancestry.com, and when fed to http://geneticgenie.org/ and http://promethease.com/, it shows VDR Taq +/+ - does this mean I need to supplement D3 above and beyond normal?

My thoughts are that either I should increase my D3 intake, or on the other hand if the tissues are resistant to accepting Vitamin D due to a receptor issue, that it will circulate in higher amounts than normal and may cause toxicity despite vitamin A intake, and I should avoid or at least lower D3 supplementation.

Hmmm, since A and D share the same receptor, does this mean that A has limited effect for me?

(Yes, sunlight for the win and now that winter has almost left, that will be possible).

So what are the intricacies of handling this mutation? (Yes, of course, epigenome wise they may not be in effect).

I also have MAO-A R297R (+/+), MTRR A66G(+/+)

And these are heterozygous: COMT V158M COMT H62H MTR A2756G MTRR A664A MTHFR C677T, MTHFR A1298C. Fun! :)

Cf08ad26759fdd206a2c9f9385080a57

(995)

on February 23, 2014
at 03:58 PM

Without CBS upregulation, you're free to throw methyl donors at it easier than I can. They would work even better without the heterozygous COMTs.

Interesting, CBS upreg can lead to whey intolerance.

Cf08ad26759fdd206a2c9f9385080a57

(995)

on February 23, 2014
at 03:45 PM

Over supplementing could downregulate the receptors, further decreasing the amount of D going in. I'm not sure as to the optimal levels for these mutations. Good question.

96440612cf0fcf366bf5ad8f776fca84

(19463)

on February 23, 2014
at 03:34 PM

That is a good thing, then. Shouldn't the D3 levels be higher than the recommended in such a case, since the receptor is damaged, and since A and D both share that same receptor, doesn't that mean I should supplement with more A as well?

Or is the toxicity level significantly higher after 40ng/ml despite additional A, and would perhaps undo the positive methyl donor sensitivity benefit?

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Cf08ad26759fdd206a2c9f9385080a57

(995)

on February 23, 2014
at 02:07 PM

VDR Taq+ helps to balance your COMT mutations to decrease methyl donor sensitivity (yay, even moods.) Regarding supplementation, I'd check your 25ohd3 and get it to 40 ng as per perfect health diet recommendations.

96440612cf0fcf366bf5ad8f776fca84

(19463)

on February 23, 2014
at 03:34 PM

That is a good thing, then. Shouldn't the D3 levels be higher than the recommended in such a case, since the receptor is damaged, and since A and D both share that same receptor, doesn't that mean I should supplement with more A as well?

Or is the toxicity level significantly higher after 40ng/ml despite additional A, and would perhaps undo the positive methyl donor sensitivity benefit?

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