I finally got my DNA results via ancestry.com, and when fed to http://geneticgenie.org/ and http://promethease.com/, it shows VDR Taq +/+ - does this mean I need to supplement D3 above and beyond normal?
My thoughts are that either I should increase my D3 intake, or on the other hand if the tissues are resistant to accepting Vitamin D due to a receptor issue, that it will circulate in higher amounts than normal and may cause toxicity despite vitamin A intake, and I should avoid or at least lower D3 supplementation.
Hmmm, since A and D share the same receptor, does this mean that A has limited effect for me?
(Yes, sunlight for the win and now that winter has almost left, that will be possible).
So what are the intricacies of handling this mutation? (Yes, of course, epigenome wise they may not be in effect).
I also have MAO-A R297R (+/+), MTRR A66G(+/+)
And these are heterozygous: COMT V158M COMT H62H MTR A2756G MTRR A664A MTHFR C677T, MTHFR A1298C. Fun! :)
asked byraydawg (19413)
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on February 23, 2014
at 02:07 PM
VDR Taq+ helps to balance your COMT mutations to decrease methyl donor sensitivity (yay, even moods.) Regarding supplementation, I'd check your 25ohd3 and get it to 40 ng as per perfect health diet recommendations.