Cancer and a Ketogenic Diet

Answered on September 12, 2014
Created January 25, 2011 at 1:53 AM

I am in need of some peer-reviewed articles/papers on how a ketogenic diet affects cancer from a nutritional standpoint.

I have to do a small research paper on the this and was wondering if the PaleoHacks community could help me find some papers on the subject.

Thanks to everyone for the help! It is much appreciated.


on December 16, 2012
at 04:52 AM

+1 thanks for posting Rose. :-)

Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

7 Answers


on January 25, 2011
at 12:46 PM

"I am in need of some peer-reviewed articles/papers..."

Here you go:

Zuccoli G, et al. Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report.
Nutrition & Metabolism. 2010, 7:33. http://www.nutritionandmetabolism.com/content/7/1/33

Seyfried TN, Mukherjee P.
Targeting energy metabolism in brain cancer: review and hypothesis. Nutr Metab (Lond). 2005; 2:30.

Zhou W, et al. The calorically restricted ketogenic diet: an effective alternative therapy for malignant brain cancer.
Nutr Metab (Lond). 2007 Feb 21; 4:5.

Otto C, et al. Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium chain triclycerides. BNC Cancer. 2008 Apr 30;8:122. http://www.ncbi.nlm.nih.gov/pubmed/18447912

Seyfried TN, et al. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Br J Cancer. 2003 Oct 6;89(7):1375???82. http://www.ncbi.nlm.nih.gov/pubmed/14520474



on September 01, 2011
at 08:23 PM

  • Kalaany-2009-Tumours with PI3K activation are resistant to dietary restriction
  • Seyfried-2010-Cancer as a metabolic disease
  • Nebeling-1992-Effects of a Ketogenic Diet on Tumor Metabolism and Nutritional Status in Pediatric Oncology Patients: Two Case Reports
  • John-2011-Dysfunctional mitochondria, not oxygen insufficiency, cause cancer cells to produce inordinate amounts of lactic acid: the impact of this on the treatment of cancer
  • Keijer-2011-Bioactive food components, cancer cell growth limitation and reversal of glycolytic metabolism
  • Mavropoulos-2009-The Effects of Varying Dietary Carbohydrate and Fat Content on Survival in a Murine LNCaP Prostate Cancer Xenograft Model
  • Schmidt-2011-Effects Of A Ketogenic Diet On The Quality Of Life In 16 Patients With Advanced Cancer A Pilot Trial
  • Meinhold-2009-Available Carbohydrates, Glycemic Load, and Pancreatic Cancer Is There a Link?
  • Kabat-2009-Repeated measures of serum glucose and insulin in relation to postmenopausal breast cancer
  • Ho-2011-A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation
  • Fine-2009-Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2



on January 25, 2011
at 02:18 PM

Do your own research!!! But, use the right tools -- GOOGLE Scholar: http://scholar.google.com/

You will find all you need, very easily, without any junk returns.

Ok, cause I am so nice, try searching with "seyfried" in the author field (of the advanced search function).



on January 25, 2011
at 02:34 AM

Are you already familiar with Dr. Thomas N. Seyfried? His research is on the effects of caloric restriction and ketogenic diet on epilepsy/brain cancer. I didn't read his papers, but I came across his name in interviews with Jimmy Moore


and Robb Wolf





on December 01, 2012
at 11:23 PM

I'm sure your research paper deadline has come and gone, lol, but here's a new paper on a pilot study done on 10 patients:

Fine et al, 2012, Targeting insulin inhibition as a metabolic therapy in advanced cancer



on December 16, 2012
at 04:52 AM

+1 thanks for posting Rose. :-)



on January 25, 2011
at 03:23 AM

Maybe the references to this blog post might help.

Answer Question

Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!