7

votes

Gut motility and the leptin RX

Answered on August 19, 2014
Created November 19, 2011 at 7:45 AM

First let me say I agree with the principles behind the leptin reset that Dr. Kruse has created, but a thought occurred to me when I was researching gastroparesis. I found that it's relatively common for people with diabetes to develop this condition because of the nerve damage that chronically elevated blood glucose levels cause, particularly to the vagus nerve which controls stomach emptying among other things. One place I read an estimate of 20%, another source said 30-50% of people with diabetes have this condition, so some corroboration of the actual estimated percentage would be helpful. Either way, people with this condition have to eat many smaller meals instead of the larger meals required for doing the leptin reset. Also, foods high in fat and protein take longer for the stomach to empty, so couldn't eating the high fat and protein meals the leptin reset requires be a problem? Since the leptin reset is designed to target people with leptin resistance and therefore insulin resistance and diabetes, how does a person with gastroparesis get around this problem? Should they eat a mostly liquid diet consisting of bone broths for a while first and then start the leptin reset? Or can they start with the leptin reset and struggle through the symptoms for a certain period of time while finding a treatment that restores the function of the vagus nerve?

Medium avatar

on December 23, 2011
at 02:34 PM

Feeling full even on an empty stomach is one indicator of gastroparesis, which means you may have a vagus nerve problem. But you have some other symptoms so yes I would ask a separate question.

7841848bd0c27c64353c583fb7971242

(7275)

on December 23, 2011
at 01:12 PM

Yeah, I would make this a new question.

7841848bd0c27c64353c583fb7971242

(7275)

on December 23, 2011
at 01:11 PM

I personally think a new question would be good.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on November 19, 2011
at 04:21 PM

It reverses slowly.....in a T2D. Reset takes longer. Got to love wireless coverage on the sea.

2b2c2e4aa87e9aa4c99cae48e980f70d

(1059)

on November 19, 2011
at 02:42 PM

FYI - Dr.K is on vacation...

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3 Answers

best answer

3
Be43f92ae60beffb567f220897032be4

on December 16, 2011
at 01:46 AM

Jack is right, but gastroparesis (frequently diabetic) is unlikely related to the vagus in anyway. It is likely related to autonomic dysfunction, and perhaps associated with gastric distention. It is closely related to GERD, and even OSA.

It is exacerbated by any high solute load (read Carbs), but a rapid rise in plasma glucose will make it acutely worse. A fast will reset things until the next dietary insult.

I have placed gastric pacemakers in patients with severe Gastroparesis with poor results. Why?

Because the gastroparesis is only one of many overwhelming problems in these patients. All of them are caused by engesting carbs. As long as you are not too far gone (which I strongly doubt), Paleo will fix all of them. Just do it!

Comeback in 60 days and tell us how it went.

0
A3477f9e7fb0cb2eed1560cd4b87ae88

on December 23, 2011
at 12:42 PM

Sorry, perhaps this should have been a new question? Let me know, and I will do that.

7841848bd0c27c64353c583fb7971242

(7275)

on December 23, 2011
at 01:11 PM

I personally think a new question would be good.

7841848bd0c27c64353c583fb7971242

(7275)

on December 23, 2011
at 01:12 PM

Yeah, I would make this a new question.

0
A3477f9e7fb0cb2eed1560cd4b87ae88

on December 23, 2011
at 12:41 PM

Hello, I wound up here searching if a Paleo Diet would help with what seems to be a vagus nerve problem. I do not have diabetes, but it is definitely set off by refined sugars (but not agave, honey, coconut sugar, or sucanat). I have a similar problem with table salt, not sea salt. It also seems to be set off by a full bladder, and colon and possibly gas. I have a calcified trachea - any coorelation to it being set off by that too? Also working out especially on my abs seems like it could be causing something. Any thoughts on any of this? I feel like I am losing my mind. I am awake all night tonight because I had a few tastes of PF Changs spicy chicken Wed night, and I licked my fingers while baking a GF/Corn Free cake for a friend because I used Turbinado Sugar. I have slept 6 hours in 2 days. And I feel like my stomach is full, with virtually nothing in it = except a banana.

Medium avatar

on December 23, 2011
at 02:34 PM

Feeling full even on an empty stomach is one indicator of gastroparesis, which means you may have a vagus nerve problem. But you have some other symptoms so yes I would ask a separate question.

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