Recently I've been trying both 5htp and tryptophan to help me sleep. However, I have dysbiosis and wondered if the tryptophan I'm taking could be feeding the bad bacteria. Sure enough I found some articles and research supporting that idea http://jamespendleton.suite101.com/the-urine-indican-test-a98984. My question is, if we assume dysbiosis is very common among people eating the standard american diet, which i believe, then how much of a role does serotonin deficiency have in depression via the bad bacteria feeding on tryptophan? I know there are many other causes of depression that have bigger roles, but the drug companies have always told us the sole cause was a deficiency of serotonin. They were wrong, but I wonder what the relationship is between the degree of dysbiosis, the inflammation and other problems it causes that lead to depression, and serotonin deficiency.
asked byChris_Antenucci (2570)
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on December 11, 2011
at 09:20 PM
According to Dr. Emily Deans, antidepressants don't work because they increase levels of serotonin. They work because they're anti-inflammatory. The hypothesis that depression is caused by serotonin deficiency isn't well supported. According to Dr. Deans, inflammation and mitochondrial dysfunction are the likely causes of depression. So, I think that dysbiosis wouldn't necessarily lead to depression because of serotonin deficiency, but rather because it is a marker of inflammation.
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