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hi i have undermethylation & pyroluria and i am looking for other people with who have the same conditions to find out as much as i can to start my life as soon as i can. can any one help?

Answered on April 21, 2014
Created April 17, 2014 at 3:44 PM

hi i have undermethylation & pyroluria and i am looking for other people with who have the same conditions to find out as much as i can to start my life as soon as i can. can any one help?

Cf08ad26759fdd206a2c9f9385080a57

(995)

on April 21, 2014
at 12:04 AM

I'm a big fan of Yasko's work. I'm double positive for MTHFR and MTRR mutations which limit my methylation of B vitamins. I take methylated B's and I've never felt better. I'm also ApoE4+, where I accumulate more metals than the average human.

Pubmed has relevant info, but the reading is dense. (over 500 articles.)

A homocysteine blood test would be worth getting as well.

http://en.wikipedia.org/wiki/Hyperhomocysteinemia#Genetic

I don't find this particularly controversial.

1a91ec126b2b4189539b028d2767e518

(320)

on April 21, 2014
at 12:01 AM

Genetic Genie uses the Amy Yasko protocol to analyze DNA SNPs. Again, this is not evidence-based medicine. Caveat emptor.

Cb9a270955e2c277a02c4a4b5dad10b5

(10989)

on April 17, 2014
at 09:33 PM

Oh shit dude, I just looked it up and think I might also have

undermethylation.

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7 Answers

0
96440612cf0fcf366bf5ad8f776fca84

(19413)

on April 21, 2014
at 10:27 AM

I got my Ancenstry.com DNA test and ran it through promethease and geneticgenie - so it turns out there's a pair of heterozygous MTHFR defects that for me is described here: http://mthfrheds.com

I've done nothing more than supplement with methyl-folate in the morning and methyl-B12 at night, and a teaspoon of L-Arginine powder for an issue with amonia disposal.

I don't notice a huge difference, but I do notice a slight one - might even be placebo, but I do recognize most of the hypermobility symptoms on that webpage apply to me, so it's probably legit. I've had pretty bad joint issues and am double-jointed, though over the ages, and with resistance excercise, they've hardened up a bit.

So my advice is get your genes tested. 23andme can't give you health results, thanks to the FDA, and even now, they're barred from accepting test kits shipped from New York State despite the change, thanks to corrupt monied interests in both the FDA and in NYS, but you can still get your raw data and feed it into promethease. I'd get these done quickly, you never know when the effin' FDA will decide to go after promethease and geneticgenie.

0
Cf08ad26759fdd206a2c9f9385080a57

(995)

on April 20, 2014
at 11:52 PM

Undermethylation, eh? Run your DNA through GeneGenie and post the results.

https://geneticgenie.org/methylation-analysis/

1a91ec126b2b4189539b028d2767e518

(320)

on April 21, 2014
at 12:01 AM

Genetic Genie uses the Amy Yasko protocol to analyze DNA SNPs. Again, this is not evidence-based medicine. Caveat emptor.

0
543a65b3004bf5a51974fbdd60d666bb

(4493)

on April 20, 2014
at 11:46 PM

i have found this site (links below) quite useful (& concise) in the past for researching different things. & it includes recommendations (to further investigate),

Pyroluria

High Histamine (histadelia)

Undermethylation

& for completeness/comparison,

Low Histamine (histapenia) & Overmethylation

(afaik, none of these 'conditions' are actually recognised by conventional medicine. Which is not to say that they do not exist or at least that the symptoms do not exist)

0
5f2b8e0a671b7eaae8a6bd97f0ded166

(120)

on April 20, 2014
at 07:54 PM

Pyroluria is an alternative theory. But the guy, Carl Curt Pfeiffer, M.D., Ph.D,

who invented this diagnosis was at least trained in medicine.

Interestingly he used B6 and Zinc to treat his patients and both of these are known

to lower estrogen. Estrogen also increases histamine.

You can search PubMed for Estrogen, B6 and Zinc.

You can fix all these problems with a good nutritious diet and

if necessary few vitamin supplements.

Beef liver is a very rich source of B vitamins,Copper and Zinc.

I know traditional doctors are not doing their job. That should not lead us to

unqualified people for healing.

0
1a91ec126b2b4189539b028d2767e518

(320)

on April 20, 2014
at 07:15 PM

Let's talk about this undermethylation thing. Who gave you this diagnosis? If as I suspect this came from a naturopath, you may want to do some more research. If this relates to something else, forgive me.

Methylation issues have been concocted by by someone who does not have any research credentials and is not a real doctor. She has created this industry of methylation treatment, which, surprise, surprise, she has the magical answer in the form of very expensive supplementation therapy.

If this is the Amy Yasko methylation stuff, I recommend you talk a long hard look at who she is:

http://www.sciencebasedmedicine.org/crank-conferences-a-parody-of-science-based-medicine-that-can-suck-in-even-reputable-scientists-and-institutions/ There???s Amy Yasko, who???s known for somehow thinking that one can treat autism (and lots of other disorders) with orally administered RNA solutions. I work with RNA all the time. It???s damned unstable. It would not survive even the saliva without being broken down into its components. Actually, RNA won???t survive long in aqueous solution without being frozen at at least -20?? C, preferably -80?? C. Yet this Dr. Yasko claims that ???we have found that by using highly specific solutions of RNAs we are able to enhance our cells natural ability to communicate with one another.??? I???d call Yasko???s woo homeopathic RNA therapy, except that apparently there are real yeast nucleotides in her concoction.

http://www.quackwatch.org/04ConsumerEducation/Nonrecorg/clayton.html"Amy Yasko, who does business as Holistic Health International and the Neurological Research Institute in Bethel, Maine, includes ND and NHD from CCNH among the six credentials listed in her resum??. Her special interest is in treating autistic children. One of her Web sites claims that using natural herbs and medicines, she has has been able to "halt and in most cases have reversed the effects of chronic adult inflammatory diseases including ALS, MS, Parkinson's disease, Alzheimer's disease, SLE, Myasthenia gravis, heart disease, sarcoidosis and polymyalgia rheumatica, among others." [7]"

http://autism.about.com/b/2008/02/27/snake-oil-for-autism-have-you-been-a-victim.htm: "Against my wishes my wife has put our autistic daughter on chealation therapy prescribed by Dr. Amy Yasko from Maine. For three years this doctor has been collecting $1000 a month from us with the promise of a cure. It turns out she is not a medical doctor. But my wife is convinced she needs a few more years to be cured. We have refinanced our house and maxed out a credit card for this program. I am fearful the stress of our non agreement on this treatment will end our family as we know it. I wish somebody would stop these evil doctors. Thanks for listening I have no one to talk to."

0
2c612e3bf373ce2fca02eb2652e8b632

on April 20, 2014
at 03:55 PM

The guy above mentioned histamines .. I agree do a search about that! I have an issue with histamines too .. the only way to stop these sensitivities is to HEAL THE GUT.

0
Cb9a270955e2c277a02c4a4b5dad10b5

(10989)

on April 17, 2014
at 09:34 PM

I read that undermethylation might be associated with high histamines. If this is the case then maybe you should take some antihistamines such as Benadryl and see if that helps.

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