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Did Glutamine make me depressed?

Answered on December 06, 2013
Created December 05, 2013 at 5:56 PM

I tried taking Glutamine (this brand and dosage) for four days a few weeks ago, and kept ending my day driving home in tears over...well, nothing.

History:

I'm no stranger to depression- I've struggled all of my life with it and was on Zoloft for 10 years, which I weaned myself off of less than a year ago. I still have problems with it but am able to cope most of the time.

Medicine/Supplements

Dostinex- Recently prescribed for high-prolactin levels .25 mg bi-weekly, note- has caused some mood disturbences

Naturethroid- 81.25 mg, recently replaced levoxyl that I'd been taking for Hashimoto's

multivitamin

Stress Assist - lots of B vitamins

cod liver oil

L-Tyrosine- 1500 mg

probiotic

magnesium

I know the easiest way to figure out if Glutamine caused this reaction is for me to start taking it again, now that my mood is re-balanced...but it was so bad I don't really want to. Has anyone had an experience like this? Why would this occur if Glutamine usually enhances mood? If it had nothing to do with Glutamine, that would be awesome because i would like to use it to heal my gut and control crab cravings.

Be157308a0438e382b88d9db4c12ab30

on December 05, 2013
at 11:02 PM

Well, I suppose I would have to agree with you, there is a chance that maybe you're sensitive to excess dietary glutamine/glutamate. Luckily glutamine is not an essential amino acid which means your body can produce all that it needs without obtaining it from the diet (except in special circumstances), so supplementation is entirely unnecessary. You might be interested in the following article describing the possible neurotoxic role of glutamine on the CNS: http://www.ncbi.nlm.nih.gov/pubmed/17006913

Medium avatar

(58)

on December 05, 2013
at 10:15 PM

Perhaps it was something else, but after going Paleo I ate a meal from Panda express (veggies, beef, sauce) and another time some beef jerky with the same effects. Dairy also has this effect on me. Gluten and grains do not and neither do seed oils....so I assumed it was the MSG.

Be157308a0438e382b88d9db4c12ab30

on December 05, 2013
at 10:09 PM

If you indeed do have a sensitivity to MSG (and to other foods with high quantities of free glutamates) then I would suggest eliminating glutamine supplements as they seem unnecessary. Also, limiting excessive protein consumption might also help reduce you overall glutamine intake since glutamine is an amino acid component of many proteins. By the way I'm not a doctor so always double check with your doctor.

Be157308a0438e382b88d9db4c12ab30

on December 05, 2013
at 10:04 PM

How do you know you are sensitive to MSG? Have you ever eaten MSG by itself? One can only be sure of food sensitivities when testing said foods in isolation. Like I said, glutamate occurs naturally in many foods, if you are sensitive to MSG you would also be sensitive to many other natural foods. One cannot be sensitive to artificial glutamate but totally fine with natural glutamate since they are the same thing, if this was the case, almost all savory foods would give you brain fog. This is why I ask how you came to conclude that MSG gives you brain fog.

Medium avatar

(58)

on December 05, 2013
at 09:47 PM

I am sensitive to MSG, I get brain fog from it. Could this be why I'm reacting adversely from the concentration of Glutamine?

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2 Answers

0
C16e2e3642960bfaabee1c1c7fbf9df1

(384)

on December 06, 2013
at 10:02 AM

It made me feel very wired and amplified my anxiety. I've read about other people having similar issues with it. The annoying thing is i found it to be really beneficial for digestive issues.

I read on another forum that the amino acids in our body are carefully balanced with each other so i'm not sure adding one without another is always the best way.

0
Be157308a0438e382b88d9db4c12ab30

on December 05, 2013
at 09:26 PM

Glutamine is synthesized in your body by the glutamine synthetase enzyme from glutamate. Glutamate is commonly found in naturally in almost all foods, but most prominently in savory foods like meat, cheese, mushrooms, tomatoes, fish, soy sauce, yeast, etc. The additive MSG (monosodium glutamate, which is just a molecule of glutamate and sodium) is often added to foods to make them extra savory. If you are buying glutamine supplements you are throwing away money, you could easily get glutamine and glutamate directly from foods or glutamate from a packet of MSG (sold by the brand Accent in the U.S.) which your body could readily convert into glutamine.

Medium avatar

(58)

on December 05, 2013
at 09:47 PM

I am sensitive to MSG, I get brain fog from it. Could this be why I'm reacting adversely from the concentration of Glutamine?

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