2

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What's the chemical connection between beef and dairy allergy?

Answered on August 19, 2014
Created December 29, 2011 at 2:28 PM

Hi,

there's an odd thing going on, I hope you can help me with this tricky issue :-)

At first:

Since milk contains a lot of potentially allergenc proteins, one must make a distinction:

  • Casein

  • a-lactalbumin

  • b-lactoglobulin

  • Bovine serum albumin

Casein is heat stable, whereas the last three guys (the whey section) is heat labile.

Now that this is clear, we come to the actual problem:

A patient was prick-testet for (IgE-mediated) food allergies and showed a reaction to raw milk, but no reaction to casein itself and milk that has been cooked at 100?? for 10 minutes. This can only mean, that he's allergic to the whey section of the milk, since they are heat labile.

Now that the only possibility of a cross reaction to beef is the BSA (bovine serum albumin), which is not heat stable, he should be able to eat well cooked beef without any issues.

BUT: Eating well cooked ground beef resulted in severe diarrhea - and I have no clue why.

Are there any other connections between dairy an beef, except the BSA protein? And if no, why didn't cooking the beef remove the allergenicity of BSA?

Thanks in advance!

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 29, 2011
at 08:09 PM

Yes it was a clean sample of ground beef, no seasoning etc

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 29, 2011
at 08:08 PM

Really interesting the connection between whey and ground beef. (and quite annoying actually, can't they just sell pure unrefined meat!?) But in this case it was a controlled sample of ground beef, therefore it was clean. And he didn't eat beef for a very long time. The high amount of fat could be a good point. Thanks :-)

Ce41c230e8c2a4295db31aec3ef4b2ab

(32564)

on December 29, 2011
at 07:44 PM

I assume he ate the beef solo & without spices? Did he re-test?

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 29, 2011
at 04:17 PM

Me too :-) Any ideas?

Ce41c230e8c2a4295db31aec3ef4b2ab

(32564)

on December 29, 2011
at 03:53 PM

Ooh, I like a mystery!

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2 Answers

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2
1c67bc28f4e44bbb8770b86df0463df3

on December 29, 2011
at 05:44 PM

If this patient never consumed cooked ground beef before in their entire lifetime, the fat probably didn't agree with their GI tract. It makes no sense whatsoever to believe that the proteins in cooked beef would cause an allergic reaction or severe GI upset. HOWEVER, a quick check on google shows articles about WHEY protein being added to ground beef, something worth looking into? It depends on whether: this patient has eaten beef before and without gi upset, then there really is not a question to be answered right?

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 29, 2011
at 08:08 PM

Really interesting the connection between whey and ground beef. (and quite annoying actually, can't they just sell pure unrefined meat!?) But in this case it was a controlled sample of ground beef, therefore it was clean. And he didn't eat beef for a very long time. The high amount of fat could be a good point. Thanks :-)

1
E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 31, 2011
at 10:48 PM

I think I've found the solution (in case anybody has a similar issue):

http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2004.00568.x/full

BSA seems to be quite resistant to cooking and also to human digestion. So even cooked ground beef can trigger a reaction.

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