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causes of high ESR and normal CRP levels

Commented on August 29, 2017
Created November 24, 2011 at 12:26 PM

Causes of high ESR and normal CRP levels

5ca0446c9373a0624bc602a248847151

(0)

on August 29, 2017
at 01:01 PM

I had ESR= 120 and normal CRP.

Turned out I had Waldenstrom's Macroglobulinemia which was diagnosed with a bone marrow biopsy.  WM is a type of Non Hodgkins Lymphoma.  It's very rare.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on December 09, 2011
at 01:35 AM

Now, I notice that ESR is typically from Quest whereas Labcorp seems to use Westgren Sedimentation Rate. The two measures do not seem to be identical: you could test at 1 on WSR but much higher on ESR. Do you know why that's the case?

Bb4b4a43f76db4977a3b63721a7c10e7

(215)

on November 24, 2011
at 02:33 PM

Could you provide a little more background on yourself, that would help to narrow things down

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1 Answers

1
69a2a5deb24d5b8d3aae3d9652fac564

(1020)

on November 24, 2011
at 11:25 PM

ESR levels can be different from CRP in that it is a less specific marker of one's inflammatory condition as NON-inflammatory conditions like anemia, pregnancy, menstration, diet changes and medications can affect ESR.

Also, ESR is slower to react to inflammatory changes. So, if something is temporal in nature, and the inflammation subsides, the CRP will reflect the decrease in inflammation more quickly than the ESR, giving you results like you experience. That's why CRP is the first line lab to draw. But since you're going to get poked for the labs anyway, most providers will almost always order both and get as much data as possible.

Now an increase in one over the other is prognostic for certain pathologies when coupled with symptoms and other markers. SLE, for example, is associated with elevated ESR with a low CRP but it's usually not something that dubious.

Steroids would also cause that condition due to the slow response of ESR.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on December 09, 2011
at 01:35 AM

Now, I notice that ESR is typically from Quest whereas Labcorp seems to use Westgren Sedimentation Rate. The two measures do not seem to be identical: you could test at 1 on WSR but much higher on ESR. Do you know why that's the case?

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