2

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Why did cream increase endotxin in this study?

Answered on August 19, 2014
Created August 05, 2011 at 4:19 PM

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858203/

Fasting normal subjects were given 300-calorie drinks of either glucose, saturated fat as cream, orange juice, or only water to ingest.

The intake of glucose did not result in any change in TLR-4 expression, whereas cream intake induced a significant increase in TLR-4 mRNA expression by 37 ?? 11% over the baseline (P < 0.05) (Fig. 1B). Orange juice or water did not induce any change in TLR-4. Similarly, there was a significant increase in TLR-4 protein levels in MNCs after cream intake by 38 ?? 18% over the baseline but not after glucose, orange juice, or water intake... Plasma endotoxin concentrations increased significantly after the intake of cream from 0.29 ?? 0.03 to 0.41 ?? 0.07 endotoxin units (EU)/ml at 3 h (45 ?? 17% over the baseline, P < 0.05) (Fig. 3B) but not after glucose, orange juice, or water intake. The concentration of LPS in plasma after the intake of cream continued to be significantly higher than basal levels up to 5 h. Endotoxin contents of cream and orange juice drinks were 104 ?? 24 and 85 ?? 21 EU/ml, respectively.

Acoding to a low carb forum poster from 2007, the cream used (land of lakes heavy whipping cream) contains:
Ingredients: HEAVY CREAM, CONTAINS 2% OR LESS OF EACH OF THE FOLLOWING INGREDIENTS;NONFAT MILK, SORBITAN MONOSTEARATE, ARTIFICIAL FLAVOR, CARRAGEENAN, SUCRALOSE, MIXED TOCOPHEROLS, NITROUS OXIDE.

5de2fffda92c0bf2be7ede10cad55546

(1781)

on August 06, 2011
at 11:07 AM

That's crazy, the ingredients of cream is CREAM, that's all, just cream..

Ab19df3ededa28f7bf7daeba8435b205

(1471)

on August 05, 2011
at 07:21 PM

i wish i could find grass fed cream...every thing in jacksonville i can find has crap in it.

E35e3d76547b18096a59c90029e7e107

(15613)

on August 05, 2011
at 06:35 PM

My favourite health blogger, hope he gets back to posting soon.

0bc6cbb653cdc5e82400f6da920f11eb

(19235)

on August 05, 2011
at 05:51 PM

"The study was supported in part by a grant from the State of Florida, Department of Citrus". I expect they liked this study :)

Be1dbd31e4a3fccd4394494aa5db256d

(17969)

on August 05, 2011
at 05:45 PM

I don't think I have appreciated Peter enough. This guy pulls obscure facts out of thin air to make sense of it all.

Be1dbd31e4a3fccd4394494aa5db256d

(17969)

on August 05, 2011
at 05:44 PM

Lol, everyone loves gratuitous nitrous oxide. Barrel O' laughs that is.

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on August 05, 2011
at 05:14 PM

that's very interesting. it's a bummer though that heavy cream intake didn't really help me much (other than getting fit). but regarding heartburn and my lipid numbers, even pure cream was not much benefit to me. Seems that if cream really does raise endotoxin, which would allow for a robust environment of gut bacteria, that it woudl probably be helpful for heartburn or GERD, given how closely associated that is with gut bacteria.

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3 Answers

6
Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on August 05, 2011
at 04:29 PM

free3337 - honestly.. with ingredients like that, it's anyone's guess, and I would be suspicious of any outcome as a result. And thank you for posting the ingredients. It adds quite a necessary element to the equation.

"NONFAT MILK, SORBITAN MONOSTEARATE, ARTIFICIAL FLAVOR, CARRAGEENAN, SUCRALOSE, MIXED TOCOPHEROLS, NITROUS OXIDE."

COMPLETE and utter idiocy. Why put this stuff in there? There are plenty of cream brands that have only one single ingredient. Cream.

These ingredients are trickery. Sucralose?? In cream. Why? Trickery. They want you to like theirs the best, and buy it again.

N.O. in cream? WTF?

Shame on Land O'Lakes.

Be1dbd31e4a3fccd4394494aa5db256d

(17969)

on August 05, 2011
at 05:44 PM

Lol, everyone loves gratuitous nitrous oxide. Barrel O' laughs that is.

3
E35e3d76547b18096a59c90029e7e107

(15613)

on August 05, 2011
at 04:42 PM

Because fat increases absorption of endotoxin?

Now the scary thing is that eating a high fat meal, probably based on any fat which generates chylomicrons, markedly increases you uptake of endotoxin from your gut, which is obviously full of gram negative bacteria. Eating short chain fatty acids or carbohydrate does not have this effect.

But the twist is:

It turns out that the immune system, that is the innate immune system (of course), continuously monitors the contents of the gut by looking at endotoxin production. Lots of bacteria mean lots of endotoxin and an active, on-guard innate immune system. Kill off 99% of your gut bacteria and exdotoxin production drops. The innate immune system goes on vacation and clostridium difficile gets in and wipes out your granny. Simple administration of oral endotoxin to the experimental mice stopped this effect completely.

So yes, it looks like chylomicrons carry endotoxin. Phew. That's better than a clostridium difficile infection!

0bc6cbb653cdc5e82400f6da920f11eb

(19235)

on August 05, 2011
at 05:51 PM

"The study was supported in part by a grant from the State of Florida, Department of Citrus". I expect they liked this study :)

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on August 05, 2011
at 05:14 PM

that's very interesting. it's a bummer though that heavy cream intake didn't really help me much (other than getting fit). but regarding heartburn and my lipid numbers, even pure cream was not much benefit to me. Seems that if cream really does raise endotoxin, which would allow for a robust environment of gut bacteria, that it woudl probably be helpful for heartburn or GERD, given how closely associated that is with gut bacteria.

Be1dbd31e4a3fccd4394494aa5db256d

(17969)

on August 05, 2011
at 05:45 PM

I don't think I have appreciated Peter enough. This guy pulls obscure facts out of thin air to make sense of it all.

E35e3d76547b18096a59c90029e7e107

(15613)

on August 05, 2011
at 06:35 PM

My favourite health blogger, hope he gets back to posting soon.

2
Medium avatar

on August 05, 2011
at 05:22 PM

Jack's got it, my brain was screaming "CARAGEENAN! I'll bet my house it's a government study and those morons just used off the shelf CAFO cream!"

Based on David Moss's answer though, I don't feel bad about my almost daily intake of about a pint of pure, grassfed heavy cream.

Ab19df3ededa28f7bf7daeba8435b205

(1471)

on August 05, 2011
at 07:21 PM

i wish i could find grass fed cream...every thing in jacksonville i can find has crap in it.

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