4

votes

What is the mechanism behind phosphatidylserine's cortisol lowering effects?

Answered on August 19, 2014
Created January 30, 2012 at 12:00 AM

Does anyone know what the molecular mechanism is behind bovine-derived phosphatidylserine's cortisol blunting effects in response to exercise?

Well thought out detailed theories are welcome too!

E4f858a9178422502c42b9719690e52c

(603)

on June 07, 2012
at 04:09 PM

Only 10% of that is phosphatidylserine though.

1a38d3adc2466cbb0ab80aac86cc7597

(88)

on January 31, 2012
at 02:35 AM

I'm interested in the molecular mechanisms behind why it might resensitize the HPA axis, very nity gritty, but this is stuff that fascinates me lol perhaps there isn't an answer at this time, but I figured I would ask.

1c67bc28f4e44bbb8770b86df0463df3

(6719)

on January 30, 2012
at 12:51 AM

http://www.amazon.com/Vitacost-Phosphatidylserine-Complex-000-serving/dp/B0045NPN3C 1 gram / 60, for less than $20

1c67bc28f4e44bbb8770b86df0463df3

(6719)

on January 30, 2012
at 12:49 AM

This stuff has been known about for a long time, its the PRIMARY active driver in 'Brain Quicken' <-- tim ferriss's supplement that he made $$$ on in order to write the 4hour work week, and then the 4 hour body, even though I don't remember seeing it written about. IMO, I would take 300mg/day, 800mg/day if training. I might buy a couple bottles and see how it goes.

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2 Answers

1
9dd74d3941535d0aaa2c8d3cf454fb7e

on January 30, 2012
at 02:29 AM

Phosphatidylserine is believed to help re-sensitize the hypothalmic-pituitary-adrenal axis to cortisol, thus reducing its overproduction:

http://www.vrp.com/hormone-support/neuroendocrine-theory-of-aging-chapter-7-restoring-receptor-sensitivity-part-iii

There have been limited studies, funded by supplement manufacturers, showing that soy derived PS limits exercise induced stress, however results of the studies are controversial: http://www.med.nyu.edu/content?ChunkIID=21843

Elsewhere on this site (think its the Adaptogens thread) I posted some links to the newly emerging fish derived phosphatidylserine supplements, along with the DHA and/or EPA conjugated forms of soy derived PS. These appear to have chemical strcutures that more closely approximate bovine derived PS. http://paleohacks.com/questions/12136/has-anyone-tried-adaptogens#axzz1ku395h27

1a38d3adc2466cbb0ab80aac86cc7597

(88)

on January 31, 2012
at 02:35 AM

I'm interested in the molecular mechanisms behind why it might resensitize the HPA axis, very nity gritty, but this is stuff that fascinates me lol perhaps there isn't an answer at this time, but I figured I would ask.

0
1c67bc28f4e44bbb8770b86df0463df3

on January 30, 2012
at 12:38 AM

1c67bc28f4e44bbb8770b86df0463df3

(6719)

on January 30, 2012
at 12:49 AM

This stuff has been known about for a long time, its the PRIMARY active driver in 'Brain Quicken' <-- tim ferriss's supplement that he made $$$ on in order to write the 4hour work week, and then the 4 hour body, even though I don't remember seeing it written about. IMO, I would take 300mg/day, 800mg/day if training. I might buy a couple bottles and see how it goes.

1c67bc28f4e44bbb8770b86df0463df3

(6719)

on January 30, 2012
at 12:51 AM

http://www.amazon.com/Vitacost-Phosphatidylserine-Complex-000-serving/dp/B0045NPN3C 1 gram / 60, for less than $20

E4f858a9178422502c42b9719690e52c

(603)

on June 07, 2012
at 04:09 PM

Only 10% of that is phosphatidylserine though.

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