2

votes

pregnenolone supplementation vs a combined hormone supplement

Answered on August 19, 2014
Created December 26, 2011 at 4:24 PM

For the past year but especially the past few months I've felt very stressed, had insomnia, unintended weight loss, and other symptoms that I believe indicate I have very high cortisol levels. I'm looking into buying a hormone supplement that balances my hormones and therefore lowers my cortisol. I also have most if not all of the symptoms of hypothyroidism so I suspect I'm very low in thyroid hormone as well. To correct this I'm wondering if I should take pregnenolone, which is the hormone from which all the steroid hormones come from, or just take a supplement that has all of the hormones combined. Maybe there could be issues with my body's ability to convert pregnenolone to the other hormones or to synthesize it from cholesterol? Also, if anyone is taking such a supplement, which product is it and what has been your experience with it? Paraplex is one I've read about so has anyone taken it or a similar product? Here's a description of it http://healthy-information.naturalhealthdoc.net/STANDARD-PROCESS-INFORMATION-SHEET/Paraplex-Information.htm. Any research or personal experience is welcome, thanks.

6cca02352c216b4ca8325fda7d83832c

(1042)

on December 27, 2011
at 07:00 AM

@Ashley Same here, and I believe there is a genetic component to stress tolerance in general and tolerance to specific stressors. Like you, sleep deprivation has always been my Achilles heel compared to all other stressors. When I get less than about 6 hours even for just one night it feels like I am dying that day until I get an adequate quantity of sleep the next night, yet other people I know seem to function as well on 4 hours of sleep as I do on 8 hours. So I completely agree with you that for treating excess stress, lifestyle modification usually trumps supplementation.

60af23519906aa54b742ffc17477c3d3

(1186)

on December 26, 2011
at 10:47 PM

Agreed. You can't put a band-aid on it. Try making your life easier and eliminating as many stressors as possible. Some can't be avoided and at that point, you may need to supplement. Personally, sleep is my biggest contributor. I function best with 9 hours, but if I get less than 8, I am a mess.

Medium avatar

on December 26, 2011
at 10:34 PM

Thanks for sharing your experience, it seems like we have similar symptoms. I also can't afford testing right now and I also believe I have low grade infections of bacteria and possibly candida.

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6 Answers

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3
77877f762c40637911396daa19b53094

(78467)

on December 26, 2011
at 08:13 PM

About a year ago I was very stressed, over sweating but cold extremities, sleep did not refresh me, unintended weight gain and a visibly enlarged thyroid gland. My symptoms were a bit different than yours but I came to the same conclusion that I was heavy on the cortisol formation and hypothyroid. I figured out to start iodine supplementing from PHD, and added 10mg of DHEA at the same time (Lifetime pharma grade, not from yams). I started to improve. What really turned things around was reading Mastering Leptin and starting Dr. Kruse's Leptin protocol. I had been fasting until noon. The BAB was a wonder. Very calm, refreshed when I wake up, thyroid shrinking, energy better, sweat pattern better. Changed to Lifetime combo of DHEA 10 mg with pregnenolone 15mg but didn't notice much difference except to grow some chin hairs! So I've dropped Lifetime and I"m trying NOW 7-Keto 25mg.

Still need to improve: I'd like more energy (like instead of sitting here with my computer in my lap!) and I need to win my battle with chronic low grade fungal infections. I need direction on the DHEA but can't afford testing. I hope you get some suggestions here. Good question.

Medium avatar

on December 26, 2011
at 10:34 PM

Thanks for sharing your experience, it seems like we have similar symptoms. I also can't afford testing right now and I also believe I have low grade infections of bacteria and possibly candida.

4
755d3a18737359da49c5e2167e5f2f63

on December 27, 2011
at 12:15 AM

I'm not sure about the wisdom of hormone supplementation for high cortisol. That said, I suffer from low cortisol/adrenal fatigue and have been taking 50mg of Pregnenolone every morning. It's the Vitamin World brand. My N=1: it helps a lot with energy levels, sex drive, and perhaps most importantly, it really helps me sleep better. I tried taking another 50mg around lunchtime, following a practitioner's advice, but it gave me insomnia. Which underscores that everyone is different and results will vary.

4
3a9aef29f44d81785622400b60fc5e14

on December 26, 2011
at 05:30 PM

Hey I have suffered from extremely high cortisol levels due to combined work and training stress and from all my research into recovery I don't believe supplementation is the right way to go. You should find out what is causing the problem and fix it from the root cause. Taking hormone supplements can be bad and it is way more important to get you natural hormones working properly again. For me getting a proper sleep and stopping training all together helped get me back to normal.

Here are 2 good links.. http://jackkruse.com/what-might-casey-anthony-and-oj-have-in-common/ http://jackkruse.com/primal-cortisol-response/

60af23519906aa54b742ffc17477c3d3

(1186)

on December 26, 2011
at 10:47 PM

Agreed. You can't put a band-aid on it. Try making your life easier and eliminating as many stressors as possible. Some can't be avoided and at that point, you may need to supplement. Personally, sleep is my biggest contributor. I function best with 9 hours, but if I get less than 8, I am a mess.

6cca02352c216b4ca8325fda7d83832c

(1042)

on December 27, 2011
at 07:00 AM

@Ashley Same here, and I believe there is a genetic component to stress tolerance in general and tolerance to specific stressors. Like you, sleep deprivation has always been my Achilles heel compared to all other stressors. When I get less than about 6 hours even for just one night it feels like I am dying that day until I get an adequate quantity of sleep the next night, yet other people I know seem to function as well on 4 hours of sleep as I do on 8 hours. So I completely agree with you that for treating excess stress, lifestyle modification usually trumps supplementation.

2
E5c7f14800c5992831f5c70fa746dc5c

(12857)

on December 27, 2011
at 01:01 PM

www.raypeat.com

0
5195c4f5dbbeba0290bd99285b505c1a

on June 11, 2013
at 02:43 AM

I also have high cortisol as well as other problems with hormone balance. The thyroid is extremely important for proper hormone balance of all other glands in the endocrine system. You could possibly have some hypothyroidism (even subclinical hypothyroidism can cause problems). You could consider supplementing iodine. Iodine is essential for proper thyroid function and is needed by other glands in the endocrine system, especially in women. Thyroid hormones like T4, T3, and TSH are all produced from iodine and tyrosine, so the body cannot produce the thyroid hormones it needs for thyroid function without iodine. It may take several months or longer to notice improvement from iodine supplementation and if you are severely deficient in iodine, you may need more of it.

I do notice benefits from using pregnenalone supplements despite the fact I have high cortisol production. The pregnenalone helps balance other hormones I'm low in. I use a supplement called Relora containing a blend of herbs used in chinese medicine for anxiety to control my high cortisol levels. I notice less tension, stress, better sleep, and blood pressure when I use Relora.

It's possible Relora could also facilitate the proper use of pregnenalone in your body by ensuring it does not all convert to more cortisol and can be used for other hormones.

Those supplements have been helpful to me, so they could benefit you, too. I've heard of some people using ashwagandha for adrenal fatigue, also, so you could look into that.

0
6a22229638cc5cd62a0ae40f2577dda5

on August 20, 2012
at 07:58 AM

Powerful Pregnenolone supplement is best drug to reduce stress. Pregnenolone was known to have a wide range of beneficial actions for people who were sick or under stress. These included helping arthritic conditions, countering fatigue, and in general improving the quality of life and awareness. Because it occurs naturally, it cannot be patented.

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