high histamine lab result - advice/views on the lab treatment recommendations (undermethylation/histadelia)

Commented on August 18, 2013
Created August 14, 2013 at 11:29 AM

hi All,

I recently tested high for histamine (blood test), result was 58.0 ug/L (range 28.0 - 51.0).

The lab report includes a 'treatment recommendations' section. It looks like the treatment recommendations are based on/sourced from a book by Carl Pfeiffer called 'Mental Illness and Schizophrenia: The Nutrition Connection' (isbn 0722514654, 978-0722514658).
...( the report includes the following text "To find out more about this, see Mental Illness: The Nutrition Connection, a book by Carl Pfeiffer").

Here are the treatment recommendations from the report to treat high histamine;

Treatment Recommendations: Methionine (amino acid) supplementation lowers blood levels of hitamine by increasing histamine breakdown. A low protein diet with high complex carbohydrates is recommended. Histidine, which is more common in animal proteins, should be avoided as it converts to histamine. Supplement with Calcium, Copper, Magnesium, Manganese, Vitamin B6 and Vitamin C.

Caution: Histadelics should avoid supplemental folic acid as it can produce excess histamine. Folic acid increases depression in histadelic patients. The treatment of histadelia requires great patience because 6-10 weeks are often needed before the beginning of significant improvement. The treatment usually takes 12 months to complete.

So, the help i am after, is with regards to two of the recommended supplements; Manganese and Copper.

Some googling has thrown back conflicting info with regards to one or both of these in dealing with high histamine. ie. no mention of them, or some sources recommended avoiding one or the other (or both).

Hopefully someone can provide some info or good references on manganese &/or copper as part the treatment for high histamine. thx

(I should add that depending on where i looked, 'high histamine' was also called 'undermethylation' or 'histadelia')



on August 18, 2013
at 10:18 PM

this 2010 document by Dr Walsh http://www.walshinstitute.org/powerpoints/Behavior-PP_3.ppsx was helpful. it could be that Walsh is a more up to date source on this than Pfeiffer (building on Pfeiffer's work perhaps?)



on August 16, 2013
at 06:01 AM

i think i have a slightly better understanding now, after reading a 2010 document by Dr Walsh here http://www.walshinstitute.org/powerpoints/Behavior-PP_3.ppsx

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