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votes

Who do "well controlled studies" offer no hints statin drugs cause significant cognitive impairment

Answered on September 12, 2014
Created July 14, 2012 at 2:13 PM

When thousands of people experience this causing Dr. Beatric Golumb to look into it?

My own dad is experiencing very sgnificant statin drug induced cognitive impairment . He has also aged about 10 years in only 2 to 3 years. All of this only because "his cholesterol was elevated 220mg/dl." Now his total cholesterol is as low as a forced down artifical 120 mg/dl

Sad state of affairs. I told me dad to confront his doctor. Before getting his cholesterol checked he was a vibrant man who looked a good 5 years less than his actual age.

What would you guys do about this doctor?

32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on July 15, 2012
at 11:42 PM

If you're going to copy/paste, post a link.

32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on July 14, 2012
at 04:31 PM

Not a paleo question...

32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on July 14, 2012
at 04:30 PM

That doesn't excuse pseudo-scientific jibber-jabber.

A201f99e84f4071875e016d7b9603276

on July 14, 2012
at 03:44 PM

Remember science cannot "prove" anything- anything.

C45d7e96acd83d3a6f58193dbc140e86

on July 14, 2012
at 02:31 PM

Get him to evaluate his diet and exercise program, and maybe see a different doctor. Some doctors are using statin prescriptions as a form of consistent residual income. People have to come in to get the check ups and a new prescription.

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4 Answers

4
D8e5242da8fc9916a3145ba12f6c5ed9

on July 15, 2012
at 08:15 PM

No studies? Oh, and this is a very SHORT list. The actual total is near 500.

Study Title: Statins May Cause Muscle Damage in Some Patients

Dr. Annette Draeger University of Bern Prof. MD Cell Biology, Head of Section Office number:B223 Phone: +41 (0)31 631 46 25 Email: draeger@ana.unibe.ch

Study Title: Statin Therapy Inhibits Remyelination in the Central Nervous System

Dr. Veronique E. Miron Montreal Neurological Hospital and Institute 3801 University Street Montreal, Quebec H3A 2B4 Telephone: 514-398-6644 Email: veronique.miron@mcgill.ca

Study Title: Genomas Presents Drug-Specific Genetic Determinants of Statin Safety and Efficacy at the XV International Symposium on Atherosclerosis

Gualberto Rua??o, M.D., Ph.D. Genomas, Inc. 67 Jefferson Street Hartford, CT 06106 860.545.4574 Email: Admin@Genomas.net

Study Title: Statin-Induced Muscle Disorders

Dr. Georgirene Vladutiu Professor; Professor of Pediatrics, Neurology and Pathology Buffalo General Hospital Robert Guthrie Biochemical Genetics Laboratory 100 High Street Buffalo NY, 14203 Phone: (716) 859-7741 Email: gvladutiu@upa.chob.edu

Study Title: Chemical Toolkit Tests Mitochondria, Reveals Machinery of Drug Effects

Vamsi K. Mootha, M.D. Department of Medicine Massachusetts General Hospital Broad Institute of MIT and Harvard Phone: (617) 643-3096 Email: vamsi@hms.harvard.edu

Paper Title: The Unholy Marriage to American Health Care (Book: Confessions of an Rx Drug Pusher)

Email: gwen@gwenolsen.com

Litigation: 07/24/09 - BC/BS alleges cholesterol drug makers hid unfavorable test results.

Blue Cross/ Blue Shield vs. Merck and Co. Inc., Schering-Plough Corp. and Merck/Shering-Plough Pharmaceuticals in the Marshall Division of the Eastern District of Texas.

Presiding Judge: The Honorable T. John Ward (903) 935-3868 ??? voice Email: None given Becky Andrews - Secretary

Study Title: Statins Provoking MELAS Syndrome

Departments of a) Internal Medicine b) Neurology, School of Medicine, University of Connecticut, Farmington, Conn., c) Department of Cardiology, Hartford Hospital, Hartford, Conn., USA Joseph E. Thomas, MD Tel. +1 860 223 7471 E-Mail drjethomas@yahoo.com

Study Title: Atrogin-1gene and the myopathy caused by HMG CoA Reductase inhibitors

Dr. Stewart Lecker: Research Beth Israel Deaconess Medical Center, Boston, Ma. Phone: 667-2147 Email: slecker@bidmc.harvard.edu

Study Title: Muscle Symptoms Associated with Statins: A Series of Twenty Patients

Author for correspondence: Kari T. Kivist??, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112,D-70376 Stuttgart, Germany Email: kari.kivisto@ikp-stuttgart.de

Study Title: Statins and risk of polyneuropathy

D. Gaist, MD PhD, U. Jeppesen, MD PhD, M. Andersen, MD PhD, L. A. Garc??a Rodr??guez, MD MSc, J. Hallas, MD PhD and S. H. Sindrup, MD PhD Dr. David Gaist, Epidemiology, Institute of Public Health, University of Southern Denmark Email: dgaist@health.sdu.dk or dg@dadlnet.dk

Study Title: SLCO1B1 Variants and Statin-Induced Myopathy ??? A Genomewide Study

SEARCH Collaborative Group Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Email: search@ctsu.ox.ac.uk.

Study Title: Increased exposure to statins in patients developing chronic muscle diseases: a 2-year retrospective study

Dr L Sailler, Unit of Pharmacoepidemiology, University of Tolouse, Toulouse, France Email: sailler.l@chu-toulouse.fr

Study Title: Statins and lupus erythematosus

B. No??l Department of Dermatology, Centre Hospitalier Universitaire Vaudois, tel. +41 21 314 04 03 Email: bernard.noel@chuv.hospvd.ch

Study Title: UCSD Statin Study

Beatrice Alexandra Golomb, MD, PhD Phone: (858) 558-4950 x201 Email: bgolomb@ucsd.edu

Paper: Unpublished THINCS documents Author: Various

                Email:  http://www.thincs.org/unpublic.htm

Study Title: An Assessment of Statin Safety by Muscle Experts

Paul D. Thompson, MD, Division of Cardiology, Hartford Hospital, E-mail: pthomps@harthosp.org

Study Title: The Role of Coenzyme Q10 in Statin-Associated Myopathy. A Systematic Review

Leo Marcoff, MD* and Paul D. Thompson, MD,a,* Hartford Hospital, Dept. of Cardiology Hartford, Connecticut

Email: pthomps@harthosp.org

Study Title: Drug-induced myopathies. An overview of thepossible mechanisms

Jacek Owczarek, Magdalena Jasi??ska, Daria Orszulak-Michalak Department of Biopharmacy, Faculty of Pharmacy, Medical University of ????d, Poland Correspondence: Daria Orszulak-Michalak, Email: dmichalak@pharm.am.lodz.pl

Study Title: Reversal of statin toxicity to human lymphocytes in tissue culture.

Pettit FH, Harper RF, Vilaythong J, Chu T, Shive W. The University of Texas at Austin, Biochemical Institute, Austin, TX 78712-0163, Email: fvhp@sbcglobal.net

Study Title: Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV

Schambelan, Morris, Professor University of California San Francisoc Department: Medicine Email: morrie@sfghgcrc.ucsf.edu

Study Title: Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV

Schambelan, Morris, Professor University of California San Francisco Department: Medicine Email: morrie@sfghgcrc.ucsf.edu

Study Title: Diplopia, blepharoptosis, and ophthalmoplegia and 3-hydorxy-3-methyl-glutaryl-CoA reductase inhibitor use.

F.W. Fraunfelder, M.D. Casey Eye Institute, Oregon Health & Science University Email: eyedrug@ohsu.edu

Study Title: The Effect of Q10 and Selenium Supplement on Muscular Adverse Events in Statin Therapy #NCT00113477

Kjetil Retterst??l, MD Rikshospitalet, HF
Pharma Nord Email: none given

Study Title: Progressive myopathy with up-regulation of MHC-I associated with statin therapy

Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre and University of Western Australia, Corresponding author: Dr. Merrilee Needham
E-mail: needhm01@uwa.edu.au

Study Title: Increased exposure to statins in patients developing chronic muscle diseases

Dr. L Sailler University of Tolouse, Toulouse, France Email: sailler.l@chu-toulouse.fr

Study Title: Genetic risk factors associated with lipid-lowering drug-induced myopathies

Georgirene D. Vladutiu, PhD New York University @ Buffalo Contact: Dr. Vladutiu Email: gdv@buffalo.edu

Study Title: Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems.

Dr. Wilhelm Auerswald Atherosclerosis Research Group (ASF) Vienna, Austria Contact Dr. Helmut Sinzinger Email: helmut.sinzinger@univie.ac.at

Study Title: Adverse side effects of statins in the oral cavity

Facultad de Medicina UAB, Barcelona, Spain Correspondence: Dra Montse Pascual Cruz E-mail: 20673mpc@comb.es

Study Title: Medication-induced mitochondrial damage and disease

Dr. John Neustadt Montana Integrative Medicine, Bozeman, MT, USA E-mail: drneustadt@gmail.com

Study Title: Statin-Associated Myopathy Is Associated With Impaired ??-Oxidation of Fatty Acids

PAUL S. PHILLIPS, MD, DIRECTOR, INTERVENTIONAL CARDIOLOGY SCRIPPS HEALTH INSTITUTE, SAN DIEGO, CA. Email: PHILLIPS.PAUL@SCRIPPSHEALTH.ORG

Study Title: Statin-induced apoptosis and skeletal myopathy

Amie J. Dirks and Kimberly M. Jones Wingate University School of Pharmacy, Wingate, North Carolina Email: adirks@wingate.edu

Study Title: Maternal exposure to statins and risk for birth defects: A case-series approach

Sonja A. Rasmussen National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia Email: skr9@cdc.gov

Study Title: Potential Adverse Effects of Statins on Muscle

Susan S Tomlinson Department of Physical Therapy, Arcadia University Glenside, PA. USA Email: tomlinsons@arcadia.edu

Study Title: Statins and lupus erythematosus

B. No??l Centre Hospitalier Universitaire Vaudois, 1005 Lausanne, Switzerland Email: bernard.noel@chuv.hospvd.ch

Study Title: Disorder resembling Guillain-Barr?? syndrome on initiation of statin therapy

Yusuf A. Rajabally, MD University Hospitals of Leicester, United Kingdom Email: yusuf.rajabally@uhl-tr.nhs.uk

Study Title: Evidence for Caution: Women and statin use

Harriet Rosenberg, Danielle Allard Women and Health Protection Toronto (Ontario) www.whp-apsf.ca Email: whp.apsf@gmail.com

Study Title: Coenzyme Q10. An independent predictor of mortality in CHF

Christopher M. Florkowski, MD, Sarah L. Molyneux, PHD The Christchurch Cardioendocrine Research Group, University of Otago (Christchurch), Christchurch, New Zealand Contact: Dr. Christopher M. Florkowski, Email: chris.florkowski@cdhb.govt.nz.

Study Title: Statin Myopathy as a metabolic muscle disease

Paul S. Phillips, Director, Interventional Cardiology Scripps Mercy Hospital San Diego, Ca. Email: Phillips.paul@scrippshealth.org

*******NEW DOWN *****

Study Title: Statins induce calcium-dependent mitochondrial permeability transition

Jesus A. Velho, et al. Universidade Estadual de Campinas, Sao Paolo, Brazil Contact: Anibal E. Vercesi Email: anibal@unicamp.br

Study Title: All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells.

Dr. S. Kaneta Department of Pharmacology, Hokkaido College of Pharmacy, Otaru, Japan. Email: info@hokuyakudai.ac.jp

Study Title: Association between statin-associated myopathy and skeletal muscle damage

Markus G. Mohaupt, MD, et al. Department of Nephrology and Hypertension, University of Bern, Bern, Switzerland Correspondence to: Dr. Annette Draeger, Email: draeger@ana.unibe.ch

Study Title: Methods and Compositions for the Treatment and Diagnosis of Statin-Induced Myopathy (BIDMC 1015)

Vikas P. Sukhatme, S.H. Lecker
Beth Israel Deaconess Medical Center Harvard Email: vsukhatm@bidmc.harvard.edu

Patent Pending: Diagnostic Assays for Predicting Patient Response to Statin Treatment http://apps.research.ufl.edu/otl/pdf/marketing/12210.pdf

Dr. Issam Zineh Assistant Professor Department of Pharmacy University of Florida Contact: Elizabeth Garami Email: egarami@ufl.edu

Study Title: Medication-induced mitochondrial damage and disease

John Neustadt, Steve R. Pieczenik Montana Integrative Medicine, Bozeman, MT, USA Contact: John Neustadt Email: drneustadt@gmail.com

Study Title: Adverse side effects of statins in the oral cavity

Dra. Montserrat Pascual Cruz Barcelona, Spain Email: 20673mpc@comb.es

Study Title Statins and Interstitial Lung Disease - A Systematic Review of the Literature and of Food and Drug Administration Adverse Event Reports

Paul D. Thompson, MD, et al. Cardiology Division, Hartford Hospital Email: pthomps@harthosp.org

Patent Pending: TREATMENT OF STATIN SIDE EFFECTS European Patent EP1343488 Kind Code: B1

Linnane, Anthony William 24 Myrtle Road, Canterbury, Victoria 3126, AU) Application #EP20010998341 Filed 11/25/2001
Link: http://www.freepatentsonline.com/EP1343488.html

Study Title: Cholesterol-lowering therapy and cell membranes. Stable plaque at the expense of unstable membranes?

Luca Mascitelli, MD E-mail: lumasci@libero.it
Comando Brigata Alpina ???Julia???
Udine, Italy

32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on July 15, 2012
at 11:42 PM

If you're going to copy/paste, post a link.

0
A201f99e84f4071875e016d7b9603276

on July 14, 2012
at 03:51 PM

Evrybody I personally know ( 6 people) who are on statins had impairment/forgetfulness of some sort ( not all as seere as my dad's necessarily) but some. Something is going on.

0
A201f99e84f4071875e016d7b9603276

on July 14, 2012
at 03:43 PM

Dr. Beatrice Golumb's research demonstrates this. There are thousands of people complaining on the internet who are on statins.

If studies do nto detect it, then that shows the flaws inherent in scienctific studies. It is not perfect.They are often extremely flawed.

All science is limited by our limited human minds.

0
32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on July 14, 2012
at 02:42 PM

Do you have support that statins cause significant cognitive impairment? Or are you basing this off of just your father's situation (N=1)?

I googled it myself, and it seems it's more an anecdotal link between the two, studies haven't conclusively shown a correlation.

A201f99e84f4071875e016d7b9603276

on July 14, 2012
at 03:44 PM

Remember science cannot "prove" anything- anything.

32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on July 14, 2012
at 04:30 PM

That doesn't excuse pseudo-scientific jibber-jabber.

Answer Question


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