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What would cause an increase in LDL?

Answered on September 12, 2014
Created January 09, 2013 at 9:17 PM

I've just had my cholesterol tested and while most numbers look good, I'm a bit concerned about the increase in LDL. Been mostly following a primal diet for the past four months, although there was definitely a fair bit of SAD eating with Christmas and New Years recently.

Here are my results (conventionally "healthy" SAD diet about a year ago results vs primal now)

CHOL 140 --> 201 (eek, trending a bit high?)

HDL 47 --> 100

LDL 80 --> 93 (my main concern)

TRIG 67 --> 42

CHOL/HDL RISK FACTOR 3.0 --> 2.01

Also my TSH went from 1.51 to .97, does that mean anything?

What could cause the increase in LDL on a (mostly) primal diet?

Thanks!

3ce6a0d24be025e2f2af534545bdd1d7

(26217)

on January 31, 2013
at 01:26 PM

Clinically speaking, the Friedewald formula has only been shown to be ineffective at high TGs (> 350). Although the Iranian study suggests it is also poor at < 100 as well.

A402a961303d312055dc0b253f29deac

(320)

on January 31, 2013
at 11:01 AM

Big effing thanks. I never heard of that formula before. BTW, the Friedewald formula is completely useless with TG < 100.

A402a961303d312055dc0b253f29deac

(320)

on January 31, 2013
at 10:59 AM

Lady, with these great lab results, I wonder why your body doesn't grow a second heart!

Medium avatar

(10611)

on January 10, 2013
at 11:37 PM

I tried the Wilfrid Brimley oatmeal method once specifically to see what would happen to my cholesterol. It went up.

Medium avatar

(10611)

on January 10, 2013
at 11:35 PM

Having that high HDL is what lowers your CV risk the most. The effect of total cholesterol is slightly negative, but 200 shouldn't be much to worry about.

0fd6f063c05a06af48b4ef896acd98a3

(5)

on January 10, 2013
at 09:17 PM

ah good to know how it is calculated, very enlightening. Thanks!

A2c38be4c54c91a15071f82f14cac0b3

(12682)

on January 09, 2013
at 10:21 PM

Your LDL increased by a parsley 13 mg/dl, so not worth worrying about in my opinion.

0fd6f063c05a06af48b4ef896acd98a3

(5)

on January 09, 2013
at 10:09 PM

so fricking awesome!! trying REALLY hard not to shove it in the faces of my housemates who are always making jokes about giving myself a heart attack with all the eggs, butter, and beef I eat. Take that you oatmeal proselytizers!

782d92f4127823bdfb2ddfcbcf961d0e

(5231)

on January 09, 2013
at 09:58 PM

Yes. The Iranian formula is more accurate at estimating LDL when triglycerides are below 100mg/dl. This is also a handy calculator: http://homepages.slingshot.co.nz/~geoff36/LDL_mg.htm

7fc82eebafd44badc73c520f44660150

(3275)

on January 09, 2013
at 09:37 PM

isn't HDL going from 47 to 100 fricking awesome! ??

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5 Answers

best answer

7
3ce6a0d24be025e2f2af534545bdd1d7

(26217)

on January 09, 2013
at 09:27 PM

The increase in your estimated LDL is a function of the decreased trigs.

Your LDL is an estimated value based upon the Friedewald Formula: LDL = TC - HDL - TG/5.0 (mg/dL). Since it is a linear equation, and your trigs dropped and your TC went up the result (LDL) goes up. That does not mean your LDL actually went up, just that the formula used to estimate it went up.

Interestingly, if you use the Iranian Formula to estimate LDL: LDL = TC/1.19 + TG/1.9 ??? HDL/1.1 ??? 38 (mg/dL) (reference http://www.ncbi.nlm.nih.gov/pubmed/18426324), your LDL went from 72.18 (SAD) to 61.1 (Primal)

782d92f4127823bdfb2ddfcbcf961d0e

(5231)

on January 09, 2013
at 09:58 PM

Yes. The Iranian formula is more accurate at estimating LDL when triglycerides are below 100mg/dl. This is also a handy calculator: http://homepages.slingshot.co.nz/~geoff36/LDL_mg.htm

0fd6f063c05a06af48b4ef896acd98a3

(5)

on January 10, 2013
at 09:17 PM

ah good to know how it is calculated, very enlightening. Thanks!

A402a961303d312055dc0b253f29deac

(320)

on January 31, 2013
at 11:01 AM

Big effing thanks. I never heard of that formula before. BTW, the Friedewald formula is completely useless with TG < 100.

3ce6a0d24be025e2f2af534545bdd1d7

(26217)

on January 31, 2013
at 01:26 PM

Clinically speaking, the Friedewald formula has only been shown to be ineffective at high TGs (> 350). Although the Iranian study suggests it is also poor at < 100 as well.

0
Ea1bb0c24b59345463ef96880b6b27fc

(300)

on January 31, 2013
at 09:34 AM

The increase in your LDL is well within the limits of statistical variability and is nothing to be concerned about. The increase in your total cholesterol is coming almost entirely from an increased HDL, not the usual pattern we see here where people are also complaining about a greatly increased LDL. Overall, these results present nothing to worry about since everything is well with accepted limits and ratios but you might want to keep an eye on your HDL. Although HDL is generally considered to be the "good cholesterol", an ever increasing HDL could be the sign of something amiss but again, at the current level its noting yet to be concerned about.

0
Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on January 10, 2013
at 04:33 PM

a Few thing things......Low Mg = low LPL activity = low HDL and higher LDL and higher TG's

Low levels of L-carnitine do as well low Q10 levels too all behind low iodine levels.

0
Dc6407193ba441d1438f6f0c06af872b

on January 10, 2013
at 01:25 AM

Also, don't forget experimental variance, including what foods you ate when the previous day. 80 to 93 is not significant, and 93 is great anyway by traditional reckoning. If your next reading is 106, then you have a trend. Right now, no trend.

0
366c23d69eadce094a2b22299c58a424

(2988)

on January 09, 2013
at 11:33 PM

This is totally going to depend on who you ask. If it were me, I'd be happier with your current panel than your old one...low cholesterol, IMHO, is not a sign of good health. You don't want it too high, mind you, but 201 is probably better than 140 (some will say 200-240 is the "sweet spot", so long as your trigs are low and HDL is high, and yours are excellent). And your LDL, as has already been pointed out, is an estimate anyway.

If your numbers ever do get too high for comfort, highly recommend all the cholesterol articles at Daily Lipid & Perfect Health Diet blogs.

Can't answer about your TSH though.

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