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What exactly is the physical difference between small dense and large buoyant LDL?

Answered on August 19, 2014
Created May 26, 2012 at 12:14 PM

At a molecular level, what is the difference difference between small dense and large buoyant LDL? Is it simply that large buoyant LDL is bigger and contains more cholesterol than small dense LDL? Are they both produced that way by the liver, or does one change into the other through some other process?

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2 Answers

1
Ddfdaa75ac9f47e01fc71162dd0d38dc

on May 26, 2012
at 01:27 PM

Go read Dr. Peter Attia's 5 part discussion of the different forms of these particles - of which there are many! - at his blog, waroninsulin.com. You'll know more about lipids than your doctor. Also go to lecturepad.org and listen to Dr. Dayspring give his lectures on the anatomy of lipids. These are aimed at continuing medical education, so it's the real deal not bro-science.

1
4de2c59d682664a54cfcd4f0979e1115

on May 26, 2012
at 01:26 PM

LDL carries fat around the body, and my understanding is large/bouyant is just filled with more fat while small/dense has less fat. I believe they are both made by the liver, and start out as the same thing -- what you eat determine if they're large (high fat) or small (high carb). Unfortunately I haven't found any good research to clarify that further.

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