9

votes

Paleo Summit Hack-a-thon: Chris Kresser, 3/1

Answered on September 12, 2014
Created March 01, 2012 at 2:50 AM

What: The Paleo Summit (see also this post)

Who: Chris Kresser ??? Integrative Medicine Practitioner

Topic: An Update on Cholesterol. The cholesterol hypothesis has its staunch proponents as well as its skeptics. So who???s right? Chris presents the latest research demonstrating why elevated cholesterol scores should not be dismissed by the skeptics. He also explains why a high cholesterol score is not always cause for a prescription.

What did you think of this presentation?

E05b8d2c9ae8a9a92341785f342f131d

(346)

on March 13, 2012
at 11:21 PM

Yep, his ability to turn his skepticism upon himself is what has made him my go-to paleo authority.

F5f742cc9228eb5804114d0f3be4e587

(7660)

on March 02, 2012
at 04:00 PM

Thanks, Sue. In that case, I'm rocking it! ;) I can't find my LDL numbers (stupid health check for a reduced insurance rate, and all they gave me was TC and HDL #s).

64433a05384cd9717c1aa6bf7e98b661

(15236)

on March 02, 2012
at 02:45 PM

Thanks Melissa, I will read the Beltowski paper. The second one I had found but it seems like they are saying leptin might have some impact on plasma cholesterol metabolism, but through an LDLR-independent pathway. Good idea with the better search term too, thanks.

5e5ff249c9161b8cd96d7eff6043bc3a

(4713)

on March 02, 2012
at 01:57 PM

It was in reference to LDL particle size tests. Previously, he was willing to rely much more heavily on them, but now is of the opinion that they aren't necessarily all that reliable or accurate.

9d43f6873107e17ca4d1a5055aa7a2ad

on March 02, 2012
at 07:37 AM

here is one that is already free http://www.jbc.org/content/276/40/37402.short also you get better results if you search for " lipoprotein receptor " rather than LDL

9d43f6873107e17ca4d1a5055aa7a2ad

on March 02, 2012
at 07:30 AM

Maybe referring to the leptin knockout mice referred to here in this review http://www.scribd.com/doc/83454391/Leptin-and-atherosclerosis lemme know if you want to read the papers referenced.

93f44e8673d3ea2294cce085ebc96e13

(10502)

on March 02, 2012
at 07:10 AM

What did he take down?

C00e493393828df34be65ddc25456c7c

(610)

on March 02, 2012
at 06:58 AM

LDL:HDL ratio ideal 2, TC:HDL ratio 3-4

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on March 02, 2012
at 04:00 AM

Actually, Chris Masterjohn says TC to HDL in some of his articles.

F5f742cc9228eb5804114d0f3be4e587

(7660)

on March 02, 2012
at 03:28 AM

Thanks for heads-up, Andy. Will recalculate...

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on March 02, 2012
at 02:56 AM

@JayJay, no I'm pretty sure I saw him say something about being thin not being a guarantee of health. I'll see if I can find it.

3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:44 AM

I find Dr. Harris' last comment quite interesting as there was a question on it recently....so does he expect obesity/overweight to be the sole predictor of CV disease? That is quite what his comment sounds like.

3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:40 AM

BTW...Kurt doesn't say anything about skinny low carbers (the effect low carber docs are looking for).

3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:37 AM

That makes sense to me....and brings us back to the fact about these labs...we're just guessing folks ;). They are educated guesses based on best current science but we are FAR away from resolution.

3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:29 AM

Actually that means 235 could be 165! Even bigger variance.

E34fbfa1bca9ae970c9c7313bf9de9f8

(1436)

on March 02, 2012
at 01:06 AM

oh, and Dr. Harris comment there regarding lipid markers is facinating (as ususal).

E34fbfa1bca9ae970c9c7313bf9de9f8

(1436)

on March 02, 2012
at 01:05 AM

Chris made a mistake on this; he meant LDL:HDL, not TC:HDL. see the comments here: http://carbsanity.blogspot.com/2012/03/live-blogging-from-paleo-summit-ix.html

742ff8ba4ff55e84593ede14ac1c3cab

(3536)

on March 02, 2012
at 12:52 AM

That's what I like about the guy.

7dc950fc76a046048e683d2a27dced37

on March 01, 2012
at 11:15 PM

Great idea! Will do.

F5f742cc9228eb5804114d0f3be4e587

(7660)

on March 01, 2012
at 07:35 PM

Beth, are you planning on doing a Paleo Summit wrap-up thread? I have so many general thoughts, it would be nice to see what others are thinking too. Like: How has the Summit changed your mind about what you eat and what do you plan on doing now?

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10 Answers

20
5e5ff249c9161b8cd96d7eff6043bc3a

(4713)

on March 01, 2012
at 07:07 PM

Honestly my favorite part was when he said he needed to take some things down off his site because he's found out contrary information. He actually stated he was wrong. Ton of respect for that. Makes me trust his opinions even more.

93f44e8673d3ea2294cce085ebc96e13

(10502)

on March 02, 2012
at 07:10 AM

What did he take down?

742ff8ba4ff55e84593ede14ac1c3cab

(3536)

on March 02, 2012
at 12:52 AM

That's what I like about the guy.

5e5ff249c9161b8cd96d7eff6043bc3a

(4713)

on March 02, 2012
at 01:57 PM

It was in reference to LDL particle size tests. Previously, he was willing to rely much more heavily on them, but now is of the opinion that they aren't necessarily all that reliable or accurate.

E05b8d2c9ae8a9a92341785f342f131d

(346)

on March 13, 2012
at 11:21 PM

Yep, his ability to turn his skepticism upon himself is what has made him my go-to paleo authority.

10
3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:50 AM

I gotta question...If all you non doctors out there have the drive to take time out of your day to learn about the nuances of cholesterol and the obvious competing theories and problems with the current paradigm WTF are YOUR DOCTORS DOING RIGHT NOW!.....Seriously skip one F'n lunch with your drug rep and listen to some freakin common sense based on CURRENT science! I hear about the side effects of these statins so frequently it makes my head spin. Make sure someone needs em before you prescribe them PLEASE!

9
96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on March 01, 2012
at 07:03 PM

I hope everyone who's participated in one of the cholesterol threads here at PH listens to this update. Chris is not an alarmist but he doesn't give medical tests a free pass either. I know I for one feel much better equipped to discuss results with my doctor after listening, and I had already followed the series he released with Chris Masterjohn.

My vote is 5 stars for this one.

7
1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on March 01, 2012
at 08:10 AM

Awesome Talk. An update on cholestrol is great for Travis, Jack and others (though maybe too simple for them). At least has some good quotes.

Eat low PUFA consumption, nutrient dense high antioxident rich foods, exercise and stress managment.

Very understandable talk on a not so easy subject.

Talks about not getting LDL particle size test... Tests are currently too variable (amongst tests)... Also studies inconsistent. except for the fact that small LDL is bad.

Likes LDL /HDL to be under 3 and better under 2. (He actually said Tcol/HDL but later corrrected it)...

total in 300-350 is bad if HDL is normal...

Tests are only accurate to 35 mg either way... So 235 could actually be 200.

If cholestrol is in 250-275 range get tested 2 more times (Over period of time???)

go to doc

screen for infection, inflamaton, micronutrient deficenyu, Full thyroid panel.

Other recs as well...

A great to watch video.

3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:29 AM

Actually that means 235 could be 165! Even bigger variance.

5
F5f742cc9228eb5804114d0f3be4e587

(7660)

on March 01, 2012
at 07:33 PM

Chris is quickly becoming my go-to guy. I absolutely trust his perspective and respect his advice. Much like j3wcy's comment, the fact that he's willing to revise his advice doesn't detract at all.

I had a hard time wrapping my head around all the cholesterol info. Reading Chris Masterjohn's website was helpful, but a bit too dense for me to absorb in one sitting. This presentation helped me put all the pieces together.

When Chris mentioned that a better predictor for risk factors is Total Cholesterol/HDL, I immediately found my latest numbers (actually paused the presentation!) and came up with 2.75 (under 3 is considered good, 2 or under is ideal). This made me feel better, but can see that I might have some work to do. Of course, that all depends on where I was in my natural variations in cholesterol numbers that particular day last November, as Chris goes on to describe.

This is one of my faves so far, right up there with Dr. Thomas O'Bryan's talk on gluten. In general, I'm finding the specific topics more educational than the general ones in this summit.

F5f742cc9228eb5804114d0f3be4e587

(7660)

on March 02, 2012
at 03:28 AM

Thanks for heads-up, Andy. Will recalculate...

3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:40 AM

BTW...Kurt doesn't say anything about skinny low carbers (the effect low carber docs are looking for).

E34fbfa1bca9ae970c9c7313bf9de9f8

(1436)

on March 02, 2012
at 01:05 AM

Chris made a mistake on this; he meant LDL:HDL, not TC:HDL. see the comments here: http://carbsanity.blogspot.com/2012/03/live-blogging-from-paleo-summit-ix.html

E34fbfa1bca9ae970c9c7313bf9de9f8

(1436)

on March 02, 2012
at 01:06 AM

oh, and Dr. Harris comment there regarding lipid markers is facinating (as ususal).

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on March 02, 2012
at 04:00 AM

Actually, Chris Masterjohn says TC to HDL in some of his articles.

3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:37 AM

That makes sense to me....and brings us back to the fact about these labs...we're just guessing folks ;). They are educated guesses based on best current science but we are FAR away from resolution.

3846a3b61bc9051e4baebdef62e58c52

(18635)

on March 02, 2012
at 02:44 AM

I find Dr. Harris' last comment quite interesting as there was a question on it recently....so does he expect obesity/overweight to be the sole predictor of CV disease? That is quite what his comment sounds like.

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on March 02, 2012
at 02:56 AM

@JayJay, no I'm pretty sure I saw him say something about being thin not being a guarantee of health. I'll see if I can find it.

C00e493393828df34be65ddc25456c7c

(610)

on March 02, 2012
at 06:58 AM

LDL:HDL ratio ideal 2, TC:HDL ratio 3-4

F5f742cc9228eb5804114d0f3be4e587

(7660)

on March 02, 2012
at 04:00 PM

Thanks, Sue. In that case, I'm rocking it! ;) I can't find my LDL numbers (stupid health check for a reduced insurance rate, and all they gave me was TC and HDL #s).

4
8949bf87b0e0aefcad10f29975e4fa2b

(8989)

on March 02, 2012
at 03:59 AM

I thought he was kind of a boring speaker, but then I found myself replaying portions and then I just started taking notes. Nerds rule.

3
64433a05384cd9717c1aa6bf7e98b661

(15236)

on March 02, 2012
at 03:31 AM

I really enjoyed his talk, my favorite of the 'paleo summit so far. I thought it was a fantastic summary of the research and the Masterjohn podcast interviews.

One question, he made the statement that Leptin signals LDL uptake by LDL receptors.?? If you are LR, the receptor signaling is blocked. Dr Kruse has also made a similar statement in his blog.... I'm sure it is true, I just haven't found a reference. I have found papers that say leptin

  • Decreases hepatic cholesterol synthesis, promotes hepatic uptake of plasma cholesterol (VanPatten and others 2001)
  • Is an important regulator of HDL cholesterol (Lundasen and others 2003)

Can anyone find me a link for a study showing Leptin regulates LDL receptors?

9d43f6873107e17ca4d1a5055aa7a2ad

on March 02, 2012
at 07:30 AM

Maybe referring to the leptin knockout mice referred to here in this review http://www.scribd.com/doc/83454391/Leptin-and-atherosclerosis lemme know if you want to read the papers referenced.

9d43f6873107e17ca4d1a5055aa7a2ad

on March 02, 2012
at 07:37 AM

here is one that is already free http://www.jbc.org/content/276/40/37402.short also you get better results if you search for " lipoprotein receptor " rather than LDL

64433a05384cd9717c1aa6bf7e98b661

(15236)

on March 02, 2012
at 02:45 PM

Thanks Melissa, I will read the Beltowski paper. The second one I had found but it seems like they are saying leptin might have some impact on plasma cholesterol metabolism, but through an LDLR-independent pathway. Good idea with the better search term too, thanks.

2
D7cc4049bef85d1979efbd853dc07c8e

(4029)

on March 01, 2012
at 11:32 PM

I listened to all parts of Kresser's podcasts with Masterjohn as guest. This PaleoSummit with Kresser is a brilliant summary of Masterjohn's 3-part podcasts. Very very worth listening to by all Paleo Hackers who wish to contribute on threads regarding cholesterol!

Top shelf!

2
2d1729002574093032132b662b536226

on March 01, 2012
at 08:35 PM

Only show so far I took notes while listening. Planning to take to the doc (cardiologist) next week.

What I am going to do differently after hearing this is cut back on supplements, cancel a VAP test, and get checked for FH. My lipid panel numbers mesh perfectly with that profile.

I also have a full thyroid panel ordered, plus Vit D, ferritin, and a few more and I have an appt with Chris coming up soon.

Chris is the best, if you ask me.

0
Aa6717c2a045f299009541b941e8a821

(340)

on March 03, 2012
at 03:07 AM

I think Chris is my favourite voice in paleo health. I have listened to all of his podcasts & trust his view as he is a self-confessed nutrition nerd who spends a lot of time reading the latest research.

Like others, I found this to be a lot easier to understand than Chris Masterjohn (who obviously knows a TONNE about this subject) which allows it to become more accessible.

I also really like his ideas on leaky gut & it has helped me deal with a lot of issues that, previous to listening to his podcast, I didn't realise were related to a compromised digestive system.

I highly recommend!

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