1

votes

Can statins cure breast cancer?

Answered on August 19, 2014
Created January 21, 2012 at 3:24 AM

That's the assertion of this article's title:

http://www.dailymail.co.uk/health/article-2089099/Breast-cancer-cure-linked-cholesterol-lowering-tablets.html

Are there potential confounders at play here?

D30ff86ad2c1f3b43b99aed213bcf461

on January 23, 2012
at 03:57 PM

Sweet, thanks for linking that.

32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on January 23, 2012
at 02:10 PM

Actual journal article: http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=CELLPRESS&_urlversion=4&_method=citationSearch&_version=1&_src=FPDF&_piikey=S0092867411015698&md5=f64ee8668d5c4953131b4774ea170609

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3 Answers

best answer

1
32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on January 23, 2012
at 02:15 PM

The fact that these are drugs that are used in hypercholesterolemia is beside the point. They happen to target the mutant p53. It's simply targeting a biosynthetic pathway, shutting it down to prevent cancer growth. Seems like a valid strategy for some cancers, when susceptible.

1
B8592e62f9804ddabae73c1103d6bcb9

(1956)

on January 23, 2012
at 04:08 PM

Statins reduce inflammation, that's what gives their positive effects, not reducing cholesterol. The reduced inflammation will help with cancer too, but there are many other ways to reduce inflammation without messing with cholesterol.

1
Medium avatar

on January 21, 2012
at 03:56 AM

Great question. Mind if I revise it slightly?

"What are the potential confounders at play here?

There are always potential confounders. Surely there are some here.

Looking forward to hearing the views of those who have knowledge and/or experience.

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