3

votes

Does strenuous endurance exercise induces hormonal and other changes which might promote cancer? Does carb loading promote cancer in endurance athletes? Paul Jaminet makes the case...sort of but not conclusively.

Answered on August 19, 2014
Created May 12, 2011 at 2:17 AM

http://perfecthealthdiet.com/?p=3474

Paul analyzes several papers that talk about biochemically how the body may be impacted by endurance exercise leading to cancer risk. And he says may

But he ends with this:

I don???t want to exaggerate the risks of endurance sports. With the exception of melanoma [8], there isn???t a clear increase in cancer incidence among marathon runners. And if this post seemed a bit tortuous, it???s because there???s no simple ???smoking gun??? pathway connecting endurance exercise to cancer.
On the other hand, endurance exercise is probably not as healthy, in terms of cancer risk, as shorter-duration activities. Also, the risk may rise substantially on high-carb or wheat-based diets. There are at least a few plausible mechanisms, not all of which I???ve discussed here, that might connect endurance exercise on grain-based high-carb low-fat diets to cancer.

Dr K has talked about endurance athletes having shorter telomeres and advocates sprinting only...400m max.

It must be that all the biochemistry Paul goes through results in shorter telomeres which is a marker of a potential shortened life.

Is there causation or a corolation? What do you think?

Will you alter your exercise regime from less endurance to shorter exercise. Or is the high of endurance exercise too good to give up?

06d21b99c58283ce575e36c4ecd4a458

(9948)

on May 13, 2011
at 05:29 AM

It's not that you are going to fall over dead doing a marathon, unless you currently have heart disease. It is about working your body so hard that you shorten your telomeres which means a shorter life span. Notice Dr K's runner patients no longer run because they see the light. Dr K has pointed out elsewhere that distance endurance runners rarely reach age 70. And I believe the average lifespan of men in the US is somewhere around 78. Take a look at this PaleoHack thread: http://paleohacks.com/questions/33826/do-you-aspire-to-be-an-elite-runner#axzz1MClvFpl8

Ffc7e0ecad8e8831b528c5d4921377cc

(942)

on May 13, 2011
at 05:21 AM

If you love to run, go for it. Eat paleo. Don't over train. Have fun with it. I did one half marathon. Don't think I would ever do a full. I doubt that I will do another half. But it was a great feeling of accomplishment. And the running club had Mark come and speak. That's where I learned about this paleo stuff, ironically.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 04:34 PM

The blogs are written but the web developer is slow as .......

667f6c030b0245d71d8ef50c72b097dc

(15976)

on May 12, 2011
at 02:01 PM

pretty good explanation Namby! That fourth paragraph there sums up the very very basic premise. well-done.

667f6c030b0245d71d8ef50c72b097dc

(15976)

on May 12, 2011
at 01:59 PM

ditto for dogs. pretty much all animals - just think of all the hours they sleep during the day, in addition to actually sleeping all night. Even my pit who i keep pretty active can easily and with no problem sleep away 18 of 24 hours a day.

742ff8ba4ff55e84593ede14ac1c3cab

(3536)

on May 12, 2011
at 01:58 PM

Almost got that blog up Dr.K?

A968087cc1dd66d480749c02e4619ef4

(20436)

on May 12, 2011
at 01:14 PM

Oooh, cats definitely know how to relax! They love to stretch and get a good rub down. Power nappers too. We could learn a lot from cats.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 12:55 PM

i do curcumin and chocolate cacoa once a day. My endurance patients are told to do it twice a day.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 12:55 PM

curcumin block both mTor pathways.....so does 99% cacoa. Rictor and Raptor are the names or mtor 1 and 2. I use Navitas cacoa. or world market 99% cacoa.

535633b57c4a4940d1e913e7a12ee791

(1013)

on May 12, 2011
at 12:44 PM

@ Dr.K, What are the factors in curcumin and cacoa that make them useful? Is it just the antioxidants?

Medium avatar

(5136)

on May 12, 2011
at 07:11 AM

incidentally, i fully believe the term "running yourself ragged" came about for a reason...and that many people are addicted to exercise (likely as a form of escapist fulfillment) with no knowledge of the importance of adequate relaxation (if you have a problem with this issue, i will send my cat over to your house and he will explain it to you, but you will have to feed the darling ba****d.)

06d21b99c58283ce575e36c4ecd4a458

(9948)

on May 12, 2011
at 03:46 AM

Tumeric contains a very small amount of curcurmin. You want cucurmin...and not as supplement in a pill. Go to a health food store that sells spices in bulk and buy it for about 50 cents and ounce Here is a website that sells the pills that pretty much lays it out. http://curcumin-turmeric.net/

B4aa2df25a6bf17d22556667ff896170

(851)

on May 12, 2011
at 03:27 AM

by curcumin, do you mean turmeric? or curcumin supplements?

06d21b99c58283ce575e36c4ecd4a458

(9948)

on May 12, 2011
at 03:04 AM

Dr K, what brand of cacoa cholate 99%? Is it available on line? I have used cacoa nibs but they are rather bitter. And is the 1-2 lbs weekly? I have been doing a teaspoon 2x per week curcurmin and cinnamon mixed in 1/2 cup green yoghurt. Is that a ton?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 02:57 AM

yes.....eat paleo and do several key things to inhibit mTor pathway consistently. My long distance runners all eat tons of curcumin and eat 1-2 lbs of 99% cacoa chocolate. The ones who have deep pockets I make get telomere lengths on.....the ones over 55 have all stopped running based upon their results. I dont have to convince them any longer running distance ages them and kills them early. They all get the numbers.

Be1dbd31e4a3fccd4394494aa5db256d

(17969)

on May 12, 2011
at 02:52 AM

If someone just has to has to has to do endurance athletics (not me! Although I like an hour long game of basketball here and there) is there anything they can do or take to mitigate the effects?

  • 06d21b99c58283ce575e36c4ecd4a458

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5 Answers

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2
Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 02:43 AM

Dexter the data is pretty clear......I dont need a RCT to tell me endurance exercise kills us. Cause it does. HIIT is hormetic and helpful. I think Paul has been reading and reading well. He is a friend of mine on FB and I have been lobbing grenades about endurance exercise for a long time. If you enjoy it.....fine. But I am in the business of advising. And based upon what we know now.....the advice is it will harm you.

B4aa2df25a6bf17d22556667ff896170

(851)

on May 12, 2011
at 03:27 AM

by curcumin, do you mean turmeric? or curcumin supplements?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 02:57 AM

yes.....eat paleo and do several key things to inhibit mTor pathway consistently. My long distance runners all eat tons of curcumin and eat 1-2 lbs of 99% cacoa chocolate. The ones who have deep pockets I make get telomere lengths on.....the ones over 55 have all stopped running based upon their results. I dont have to convince them any longer running distance ages them and kills them early. They all get the numbers.

06d21b99c58283ce575e36c4ecd4a458

(9948)

on May 12, 2011
at 03:46 AM

Tumeric contains a very small amount of curcurmin. You want cucurmin...and not as supplement in a pill. Go to a health food store that sells spices in bulk and buy it for about 50 cents and ounce Here is a website that sells the pills that pretty much lays it out. http://curcumin-turmeric.net/

535633b57c4a4940d1e913e7a12ee791

(1013)

on May 12, 2011
at 12:44 PM

@ Dr.K, What are the factors in curcumin and cacoa that make them useful? Is it just the antioxidants?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 12:55 PM

i do curcumin and chocolate cacoa once a day. My endurance patients are told to do it twice a day.

742ff8ba4ff55e84593ede14ac1c3cab

(3536)

on May 12, 2011
at 01:58 PM

Almost got that blog up Dr.K?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 04:34 PM

The blogs are written but the web developer is slow as .......

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on May 12, 2011
at 12:55 PM

curcumin block both mTor pathways.....so does 99% cacoa. Rictor and Raptor are the names or mtor 1 and 2. I use Navitas cacoa. or world market 99% cacoa.

06d21b99c58283ce575e36c4ecd4a458

(9948)

on May 12, 2011
at 03:04 AM

Dr K, what brand of cacoa cholate 99%? Is it available on line? I have used cacoa nibs but they are rather bitter. And is the 1-2 lbs weekly? I have been doing a teaspoon 2x per week curcurmin and cinnamon mixed in 1/2 cup green yoghurt. Is that a ton?

Be1dbd31e4a3fccd4394494aa5db256d

(17969)

on May 12, 2011
at 02:52 AM

If someone just has to has to has to do endurance athletics (not me! Although I like an hour long game of basketball here and there) is there anything they can do or take to mitigate the effects?

2
3c6b4eed18dc57f746755b698426e7c8

on May 12, 2011
at 05:45 AM

Is there correlation? We do have some anecdotal accounts. Grete Waitz (cancer), Alberto Salazar (multiple heart attacks ... but bad genetics and hypertension, according to him), Jimmy Fixx, etc. Countless others, according to those who support the theory.

But the best anecdotal evidence I've heard is this one by Kent Rieske: Why is it always the Marathoners who are collapsing and dying, not those in the stands watching the sport who outnumber the runners, who would presumably be less fit cardiovascularly?

Maybe there is something to this, eh? This is probably the best casual evidence based purely on cursory observation.

But whatever happened to the simple theory that endurance sports result in chronic inflammation throughout the body, due to elevated cortisol, insulin, etc., and that this inflammation is the start of all modern diseases: diabetes, CVD, cancer, and autoimmunity? If the atheletes are eating carb-heavy diets, and if the carbs are not from safe starches but include sugar and fructose (horrors), is it so far-fetched that they're falling by the wayside with cancer and CVD prematurely?

Sugar/Fructose + Refined Carbs + Oxidative Stress from Endurance Exercise ==> High Cortisol + High Insulin => Chronic Inflammation => CVD and Cancer

667f6c030b0245d71d8ef50c72b097dc

(15976)

on May 12, 2011
at 02:01 PM

pretty good explanation Namby! That fourth paragraph there sums up the very very basic premise. well-done.

1
4e813fcf7266312684862b945c1c3281

(462)

on May 13, 2011
at 02:02 AM

I LOVE to run and am training for a half marathon. What is considered "unhealthy" for running? I would love to do an occasional marathon personally, and don't want to fall over dead...

Ffc7e0ecad8e8831b528c5d4921377cc

(942)

on May 13, 2011
at 05:21 AM

If you love to run, go for it. Eat paleo. Don't over train. Have fun with it. I did one half marathon. Don't think I would ever do a full. I doubt that I will do another half. But it was a great feeling of accomplishment. And the running club had Mark come and speak. That's where I learned about this paleo stuff, ironically.

06d21b99c58283ce575e36c4ecd4a458

(9948)

on May 13, 2011
at 05:29 AM

It's not that you are going to fall over dead doing a marathon, unless you currently have heart disease. It is about working your body so hard that you shorten your telomeres which means a shorter life span. Notice Dr K's runner patients no longer run because they see the light. Dr K has pointed out elsewhere that distance endurance runners rarely reach age 70. And I believe the average lifespan of men in the US is somewhere around 78. Take a look at this PaleoHack thread: http://paleohacks.com/questions/33826/do-you-aspire-to-be-an-elite-runner#axzz1MClvFpl8

1
Medium avatar

(5136)

on May 12, 2011
at 06:38 AM

aren't biomechanics and overall physical prowess a bit of a factor? i mean, the chicago marathon used to pass my house, and we were at "the wall", mile 20 and it was amazing to see how different people's bodies handled running. We used to pull out the lawn chairs and a bloody mary and watch them go by. One person would seem like they were putting out no effort whatsoever and simply gliding along, and the person next to them going the same exact pace looked like they were giving the hardest effort of their life. It also always made me ask myself "who is doing the harder effort? the front runners who do this in 2 hours with gliding biomechanics or the middle of the road person who works hard at a slightly lower but bouncier, more jarring intensity for much much longer?" Personally, I always though the guy who was there for 4-5 hours had a much harder race than the guy who could do it in 2.

Medium avatar

(5136)

on May 12, 2011
at 07:11 AM

incidentally, i fully believe the term "running yourself ragged" came about for a reason...and that many people are addicted to exercise (likely as a form of escapist fulfillment) with no knowledge of the importance of adequate relaxation (if you have a problem with this issue, i will send my cat over to your house and he will explain it to you, but you will have to feed the darling ba****d.)

667f6c030b0245d71d8ef50c72b097dc

(15976)

on May 12, 2011
at 01:59 PM

ditto for dogs. pretty much all animals - just think of all the hours they sleep during the day, in addition to actually sleeping all night. Even my pit who i keep pretty active can easily and with no problem sleep away 18 of 24 hours a day.

A968087cc1dd66d480749c02e4619ef4

(20436)

on May 12, 2011
at 01:14 PM

Oooh, cats definitely know how to relax! They love to stretch and get a good rub down. Power nappers too. We could learn a lot from cats.

0
3564823c122649ff526850d2728e8812

on January 16, 2013
at 09:20 PM

Most evidence actually shows that endurance athletes adapt well to the oxidative stress from their training and racing. There is a decline in DNA damage after Ironman triathlons. See this article for references:

The Truth about Extreme Exercise, Oxidative Stress, and Your Health

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