Anyone have any experience or knowledge about this drug aside from what the pharmaceutical companies say?
A close family member had an early stage 1 breast cancer removed and has been undergoing radiation for a few months. They now want to put her on this drug for 5 years.
She's always eaten pretty well and has a healthy weight. 65 years old, started eating paleo about a year ago and only in the past 6 months has given up dairy with a huge health improvement.
asked byJeff__1 (15236)
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on January 16, 2012
at 09:08 AM
Not sure what the pharmaceutical companies line is on Adex, but it's an AI (aromatase inhibitor) which basically means it blocks the enzyme (aromatase) that makes estrogen. Estrogen is required for the growth of breast cancers and other fibrous lumps (this is why it's commonly used by dudes after a steroid cycle - to prevent man boobs from what's known as "estrogen rebound"). Adex is effective at around 50%, meaning it will effectively reduce estrogen by 50% at normal levels. While I'm not a doctor, I'd suggest a "normal" dose is between 1-2mg per week, spread over the week (normally every few days as it has around a 2 day half-life).
Anyway - it's quite clearly a preventative treatment to help prevent cancer relapse incase they missed any. Obviously it's worth doing, but it will definitely permanently screw up your family members endocrine system.
It's very mildly toxic to the liver, as are any orally administered hormones at they need special binding to avoid being destroyed during first stage digestion. I'd therefore recommend permanent supplementation of something like Liv52 or milk thistle (there are zero side effects to these, they are just OTC supps, so no reason not to do this)
It may be worth looking into 'pulsing'. This is where you take it for a period, then cease for a period (say 8 weeks on, 4-8 weeks off) to give your endocrine system a chance to recogver itself between bouts). Obviously diccuss this with your doc however; and I'm 99% sure they won't recommend it. Honestly, I have no idea about cancer formation so can't possibly give a recommendation here.
Anyway, a bit of food for thought.