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Any thoughts on Vitamin A supplementation and melanoma? What do you think of this new paper?

Answered on August 19, 2014
Created March 19, 2012 at 5:13 PM

I know correlation doesn't = causation but ... I can't get into the original article because it hasn't been published yet, so maybe I just have to wait. http://www.ncbi.nlm.nih.gov/pubmed/22377763

J Invest Dermatol. 2012 Mar 1. doi: 10.1038/jid.2012.21. [Epub ahead of print] Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort. Asgari MM, Brasky TM, White E.

Source 1] Division of Research, Kaiser Permanente Northern California, Oakland, California, USA [2] Department of Dermatology, University of California, San Francisco, San Francisco, California, USA.

Abstract Laboratory data suggest that intake of vitamin A and carotenoids may have chemopreventive benefits against melanoma, but epidemiological studies examining the association have yielded conflicting results. We examined whether dietary and supplemental vitamin A and carotenoid intake was associated with melanoma risk among 69,635 men and women who were participants of the VITamins And Lifestyle (VITAL) cohort study in western Washington. After an average of 5.84 years of follow-up, 566 incident melanomas were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of melanoma associated with dietary, supplemental, and total vitamin A and carotenoid intake after adjusting for melanoma risk factors. Baseline use of individual retinol supplements was associated with a significant reduction in melanoma risk (HR: 0.60; 95% CI: 0.41-0.89). High-dose (>1,200?????g per day) supplemental retinol was also associated with reduced melanoma risk (HR: 0.74; 95% CI: 0.55-1.00), as compared with non-users. The reduction in melanoma risk was stronger in sun-exposed anatomic sites. There was no association of melanoma risk with dietary or total intake of vitamin A or carotenoids. Retinol supplementation may have a preventative role in melanoma among women.

Journal of Investigative Dermatology advance online publication, 1 March 2012; doi:10.1038/jid.2012.21.

9d43f6873107e17ca4d1a5055aa7a2ad

on March 19, 2012
at 05:53 PM

I'd be curious to know what kind of retinol supplement they used. A common retinol supplement is cod liver oil.

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2 Answers

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4781cf8ae1bfcb558dfb056af17bea94

(4359)

on March 19, 2012
at 07:50 PM

Another potential example of synergism. Most cancers may well just be caused by a deficiency in fat soluble vitamins...

0
4781cf8ae1bfcb558dfb056af17bea94

(4359)

on March 19, 2012
at 07:49 PM

Another potential example of synergism. Most cancers may well just be a deficiency in fat soluble vitamins...

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