2

votes

Why does caffeine not affect certain people?

Answered on June 24, 2017
Created January 13, 2013 at 11:06 PM

Is there any physiological reason why caffeine doesn't seem to work for me? I am not a regular coffee drinker (probably indulged around 8 times in the past year). I do indulge in 3 squares of 85-90% dark chocolate about 2x weekly. Lately I've been drinking yerba mate, which has slight levels of caffeine in it, I believe. However, I don't think this is reason enough for me to have developed a high caffeine tolerance yet.

Today, I drank 2 espresso shots at Peet's and didn't feel any difference in my energy levels. I am wondering if this hints at something in my physiology (good or bad).

Any thoughts, ideas are appreciated.

Notes= I sleep 7-9 hrs a night (lately, I've been sleeping around 1:30am and waking up at 10:30am, which doesn't seem ideal but I've noticed that caffeine hasn't affected me in the past when I was sleeping earlier ie 11pm). I eat clean, whole food sources, with the occasional non-paleo meal.

56e6c14445ef72f1bb9f46704e067ec3

on January 28, 2017
at 12:48 PM

          I am the same way as you when it comes to the effects of caffine on my mind and body. I love coffee so much i think i actually have an addiction to it. I drink at least 6 10oz cups of extra bold dark roast (always) per day and even double that and more if im home all day and stay up late. I average id say 7 to 8 10oz cups a day overall so i know i have a high tolerance for caffine but either way, i know it has no effects when it comes to the shakes from over caffinating if thats a word nor do i have trouble sleeping right after drinking a cup. The only noticable effects caffine has on me is when i go all day without any. I start to get headaches and feel irratable when i go 6 or 8 hours without a cup. I do not have the luxery of having my familys DNA unfortunately but my father is definitely a type A overactive mind and gets the shakes almost right away, id say half way through one cup of coffee. If he drinks a cup at 6pm he wont be able to sleep for another 6 hours or more. He is a terrible sleeper to begin with so i do wonder how much of it is mental, but, nevertheless he is hugly effected by caffine. I wish i knew more about why coffee seems to have no effect on me other than the negative ones from what i suspect to be withdraweral. I must admit though, that first sip always gets the endorphins going and i do sometimes feel a slight wash of happyness almost right away. Thanks for your time. 

                  - Brian

4ee18ffbedcb39834ad230a5130cc760

(0)

on April 13, 2016
at 05:50 PM

I have ADD (not the H part lol) But caffeine has no effect on me. I am usually tired, I could drink an espresso, with no effects. I have even taken weightloss pills with tons of caffeine, and nothing...notta... 

Cf08ad26759fdd206a2c9f9385080a57

(995)

on July 09, 2013
at 05:04 AM

Also http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=21357676. Interestingly, my dad who drinks a ton of coffee has a (CT) genotype at rs2472297, where mine is a (CC) http://i.imgur.com/kjDlLzi.png. I'm guessing you're more the AA/TT type.

Cf08ad26759fdd206a2c9f9385080a57

(995)

on July 09, 2013
at 04:59 AM

More info http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=16522833. My dad is a fast metabolizer (AA) and loves the stuff. I'm a slower metabolizer (AC) and have to go easy on it. My sister is a (CC) http://i.imgur.com/7YYikUe.png. Fun stuff having your family's DNA on file.

F0a9dea438e7943fa05da318773e785e

on January 14, 2013
at 03:41 PM

I feel for you rawrlife. Caffeine by itself does very little for me. :)

F0a9dea438e7943fa05da318773e785e

on January 14, 2013
at 03:40 PM

OP and I must have whackadoodle genes then. I can drink an entire pot of coffee and not feel a thing.

Ebb10603524dd22621c1155dd7ddf106

(19150)

on January 14, 2013
at 03:22 PM

@Doug - yes indeed, mate has levels high as most normal roast coffee.

32be195157f00ad15a933b8bb333dcc4

(379)

on January 14, 2013
at 02:47 AM

I thought yerba mate had a boatload of caffeine?

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8 Answers

4
874ff271ca3379984344d5f9f760fec3

on January 14, 2013
at 12:29 PM

Genetics is one reason. Caffeine is primarily metabolized by the liver enzyme cytochrome P450 1A2 (CYP1A2). The form of the SNP rs762551 a person has determines how fast CYP1A2 metabolizes caffeine

http://snpedia.com

F0a9dea438e7943fa05da318773e785e

on January 14, 2013
at 03:40 PM

OP and I must have whackadoodle genes then. I can drink an entire pot of coffee and not feel a thing.

Cf08ad26759fdd206a2c9f9385080a57

(995)

on July 09, 2013
at 04:59 AM

More info http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=16522833. My dad is a fast metabolizer (AA) and loves the stuff. I'm a slower metabolizer (AC) and have to go easy on it. My sister is a (CC) http://i.imgur.com/7YYikUe.png. Fun stuff having your family's DNA on file.

Cf08ad26759fdd206a2c9f9385080a57

(995)

on July 09, 2013
at 05:04 AM

Also http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=21357676. Interestingly, my dad who drinks a ton of coffee has a (CT) genotype at rs2472297, where mine is a (CC) http://i.imgur.com/kjDlLzi.png. I'm guessing you're more the AA/TT type.

0
53b42643c8bab56c79ba0b9c819ff5c8

on June 24, 2017
at 06:59 AM

Hello I know this post is old. I'm the same way. Nothing is effective. I can't seem to find anything that will give me that burst of energy that everyone else gets from caffeine. My concern is, how is it genetic? My parents love coffee and get energy from caffeine, as well as my sister and grandparents. I seem to be the only one that gets no reaction from it. But my metabolism has always been slow.  Idk. Best bet is to just check with the professionals lol.

0
Be7048c80460c6eb79bce0df0fdd3e99

on November 17, 2016
at 04:59 AM

I am the same as you; I don't experience any kind of "energizing" affect when I drink coffee or any kind of caffeine. However, I still drink it because I enjoy the taste. I also regularly drink tea. I'm not sure if this is genetic though because my father is addicted to coffee, and he has to have it or he gets mad. He does feel the energizing affect so it may be a natural tolerance thing. 

0
50f65337b8e58f0c3ca6665c4a55f8b1

on July 22, 2015
at 12:25 AM

Hi CloudsInSkies (great screen name, btw),

Just to tail on to what the other chaps/chappettes have illuded to, here, already, genetics CAN definitely play a role in it, as there is supposedly, according to researchers, a sort of "caffeine gene" (slick rhyming, amirite.).... but from everything that I've read and come to understand, it seems as thought genetics is not the ONLY thing at play in the idea of caffeine not affecting certain people in the way it does most. Alongside with just simple tolerance, I read one article that made an interesting comparison in that for some people (those with ADD or ADHD), drugs like Ritalin and Adderrall can help calm them down and focus, while for those WITHOUT ADD or ADHD, those very same drugs will get them twelve types of jacked up til next Tuesday.... I know that's not coffee or caffeine, but I thought that was an interesting comparison.

It should be noted, by the way, that I am in NO way a doctor, scientist, or anyone with excessive knowledge in any field related to your question.... I just like to read a lot :)

 

I hope that helped at all, even in the slightest.

0
5b80caf88cc810f17266212b44599906

on July 26, 2013
at 06:39 PM

As mentioned already, it is genetic. My father cannot tolerate coffee, and neither can I. If I drink one cup, I am not able to sleep for twelve hours after, and I will be irritated and getting popped ears. Funnily enough, we tolerate black tea quite fine, but I can only drink it with sugar, so I stay away from it too. Better get some good night sleep instead.

0
Baf8096c96b4d3c17053816f9f833a25

on July 26, 2013
at 05:20 PM

I am the same way. i get so tired during the work day about mid way through and I have tried five hour energy and coffee and soda and i get no effect from them. yet I have friends that take half a five hour energy and they are energized the whole day. I do not drink coffee at all, but I do enjoy hot chocolate and different hot teas. It may just be genetic. I don't drink tons of water either that may also be a reson-not being hydrated enough for the caffine to circulate your body.

0
334ae4564b6bed48a8aa5d7bd595971c

on July 09, 2013
at 04:43 AM

I Have the same issue, I never drink coffee, but I can chug two monsters with no effects at all.I think it's genetics, or maybe a natural tolerance.

0
5f678ffff153bfc8a17ac1ee438c054f

on January 14, 2013
at 02:43 AM

I don't know if this would explain all instances the caffeine didn't work for you, but I know that if you have an inadequate amount of water with coffee or another caffeine source, it doesn't distribute through your body as efficiently.

Regardless, I am sure there isn't something wrong with you just because caffeine doesn't seem to work. If you are looking for more energy you can try some supplements like vitamin D or CoQ10. Those seem to work for some people!

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