Is there any physiological reason why caffeine doesn't seem to work for me? I am not a regular coffee drinker (probably indulged around 8 times in the past year). I do indulge in 3 squares of 85-90% dark chocolate about 2x weekly. Lately I've been drinking yerba mate, which has slight levels of caffeine in it, I believe. However, I don't think this is reason enough for me to have developed a high caffeine tolerance yet.
Today, I drank 2 espresso shots at Peet's and didn't feel any difference in my energy levels. I am wondering if this hints at something in my physiology (good or bad).
Any thoughts, ideas are appreciated.
Notes= I sleep 7-9 hrs a night (lately, I've been sleeping around 1:30am and waking up at 10:30am, which doesn't seem ideal but I've noticed that caffeine hasn't affected me in the past when I was sleeping earlier ie 11pm). I eat clean, whole food sources, with the occasional non-paleo meal.
asked bycloudsinskies (767)
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on January 14, 2013
at 12:29 PM
Genetics is one reason. Caffeine is primarily metabolized by the liver enzyme cytochrome P450 1A2 (CYP1A2). The form of the SNP rs762551 a person has determines how fast CYP1A2 metabolizes caffeine
on June 24, 2017
at 06:59 AM
Hello I know this post is old. I'm the same way. Nothing is effective. I can't seem to find anything that will give me that burst of energy that everyone else gets from caffeine. My concern is, how is it genetic? My parents love coffee and get energy from caffeine, as well as my sister and grandparents. I seem to be the only one that gets no reaction from it. But my metabolism has always been slow. Idk. Best bet is to just check with the professionals lol.
on November 17, 2016
at 04:59 AM
I am the same as you; I don't experience any kind of "energizing" affect when I drink coffee or any kind of caffeine. However, I still drink it because I enjoy the taste. I also regularly drink tea. I'm not sure if this is genetic though because my father is addicted to coffee, and he has to have it or he gets mad. He does feel the energizing affect so it may be a natural tolerance thing.
on July 22, 2015
at 12:25 AM
Hi CloudsInSkies (great screen name, btw),
Just to tail on to what the other chaps/chappettes have illuded to, here, already, genetics CAN definitely play a role in it, as there is supposedly, according to researchers, a sort of "caffeine gene" (slick rhyming, amirite.).... but from everything that I've read and come to understand, it seems as thought genetics is not the ONLY thing at play in the idea of caffeine not affecting certain people in the way it does most. Alongside with just simple tolerance, I read one article that made an interesting comparison in that for some people (those with ADD or ADHD), drugs like Ritalin and Adderrall can help calm them down and focus, while for those WITHOUT ADD or ADHD, those very same drugs will get them twelve types of jacked up til next Tuesday.... I know that's not coffee or caffeine, but I thought that was an interesting comparison.
It should be noted, by the way, that I am in NO way a doctor, scientist, or anyone with excessive knowledge in any field related to your question.... I just like to read a lot :)
I hope that helped at all, even in the slightest.
on July 26, 2013
at 06:39 PM
As mentioned already, it is genetic. My father cannot tolerate coffee, and neither can I. If I drink one cup, I am not able to sleep for twelve hours after, and I will be irritated and getting popped ears. Funnily enough, we tolerate black tea quite fine, but I can only drink it with sugar, so I stay away from it too. Better get some good night sleep instead.
on July 26, 2013
at 05:20 PM
I am the same way. i get so tired during the work day about mid way through and I have tried five hour energy and coffee and soda and i get no effect from them. yet I have friends that take half a five hour energy and they are energized the whole day. I do not drink coffee at all, but I do enjoy hot chocolate and different hot teas. It may just be genetic. I don't drink tons of water either that may also be a reson-not being hydrated enough for the caffine to circulate your body.
on July 09, 2013
at 04:43 AM
I Have the same issue, I never drink coffee, but I can chug two monsters with no effects at all.I think it's genetics, or maybe a natural tolerance.
on January 14, 2013
at 02:43 AM
I don't know if this would explain all instances the caffeine didn't work for you, but I know that if you have an inadequate amount of water with coffee or another caffeine source, it doesn't distribute through your body as efficiently.
Regardless, I am sure there isn't something wrong with you just because caffeine doesn't seem to work. If you are looking for more energy you can try some supplements like vitamin D or CoQ10. Those seem to work for some people!