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How can you protect NMDA channels?

Answered on August 19, 2014
Created May 06, 2012 at 11:47 PM

The Quilt has said in a previous post:

Another thing I ask my younger paleo's to do is this......maximally eat to protect your brain before the age of 30.....You have to protect you NMDA channels and you must protect against glutamate toxicity in the brain. Excitotoxins destroy the real controller of our metabolism and that is the hypothalamus. Avoid aspartame MSG and sucralose and saccharin at all costs. And if you have used a ton reverse and protect what is left with N acetyl cysteine, tumeric, resveratrol in as high a doses as you can afford. Obviously this is a bigger focus in older paleos i treat but this is huge for young...(http://paleohacks.com/questions/28471/doctors-what-are-the-most-important-medical-things-us-paleos-dont-know-about#ixzz1u8RQyWMM)

What can I add to my diet to reverse the neurological damage done by excitotoxins?

This is my current understanding: 1) Turmeric is a spice so I guess I can use it as a spice for cooking. 2) Resveratol is found in grapes, berries and chocolate...I don't eat any of these three items. So what else can I include in my diet? 3) N acetyle cysteine is a dietary supplement and derivative of cysteine. So can I just focus on getting enough cysteine?

I am not interested in taking dietary supplements. Thank you!

5ef574d7893bc816ec52e04139e9bc09

(6097)

on May 07, 2012
at 12:15 AM

Unless you spent the first 10 years of your live subsisting on aspartame and MSG, I wouldn't be too concerned about neurological damage.

5ef574d7893bc816ec52e04139e9bc09

(6097)

on May 07, 2012
at 12:13 AM

I don't know. However, I think neurotoxicity is bad in any case. I would base any supplementation on thorough clinical data; I would be hesitant to take in unnaturally high quantities of chemicals like resveratrol, and I would also tend to doubt their efficacy.

92d67b02a709cad2250f10848f9178e6

(2422)

on May 07, 2012
at 12:03 AM

Thanks! I am already in ketosis (50g of carbs a day) and I do intermittent fasting (20-24 hours) everyday. Do you think his theory about NMDA channels being damaged by excitotoxins is valid, though? Also, if reversal through dietary supplementation is possible?

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1 Answers

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5ef574d7893bc816ec52e04139e9bc09

(6097)

on May 06, 2012
at 11:55 PM

First, I will caveat this by saying that you want to be careful about blindly accepting Mr. Kruse's assertations. He has a very colorful history of making shit up.

However, to answer your question, consider a ketogenic diet, for the reason that "ketogenic diets seem to favor glutamate becoming GABA rather than aspartate."

5ef574d7893bc816ec52e04139e9bc09

(6097)

on May 07, 2012
at 12:15 AM

Unless you spent the first 10 years of your live subsisting on aspartame and MSG, I wouldn't be too concerned about neurological damage.

5ef574d7893bc816ec52e04139e9bc09

(6097)

on May 07, 2012
at 12:13 AM

I don't know. However, I think neurotoxicity is bad in any case. I would base any supplementation on thorough clinical data; I would be hesitant to take in unnaturally high quantities of chemicals like resveratrol, and I would also tend to doubt their efficacy.

92d67b02a709cad2250f10848f9178e6

(2422)

on May 07, 2012
at 12:03 AM

Thanks! I am already in ketosis (50g of carbs a day) and I do intermittent fasting (20-24 hours) everyday. Do you think his theory about NMDA channels being damaged by excitotoxins is valid, though? Also, if reversal through dietary supplementation is possible?

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