Looking for autoimmunity and leaky gut proof

Answered on August 19, 2014
Created July 12, 2012 at 2:11 PM

So this interview by Sean Croxton of Dr Thomas O'Bryan was very interesting and I would love to believe everything he says.

So I'm looking for research that backs up these claims:

  • Autoimmunity needs this trilogy to develop:
    • Genetic vulnerability
    • Environmental trigger
    • Intestinal permeability (leaky gut)
  • Autoimmune diseases are the number 3 cause of morbidity and mortality in industrialized countries
  • Autoimmune diseases are more prevalent in women
  • 25-60% of people of European descent is gluten intolerant
  • The normal tests used for gluten sensitivity have 50% false negatives

Furthermore I'd like to find generally accepted medical literature that backs up his explanation of intestinal permeability (paraphrased):

  • Your intestines are covered with microvilii, each one specialized in getting a specific thing into the body in a controlled manner
  • They are covered with intestinal lining. If that lining gets disrupted you have intestinal permeability.
  • Intestinal permeability leads to absorbing longer proteins instead of just amino acids
  • When a chain of just 6 amino acids (a peptide) looks like e.g. some molecule on thyroid cells and you develop an immune response to it, your body will start attacking the thyroid. (molecular mimicry)

Bonus content: I found the March 2007 SciAm article he refers to online for free (legally), it convinces me of the predictive antibodies hypothesis.



on July 13, 2012
at 09:54 PM

Dunno about the specifics as to what you ask, but there is a previous thread with a lot of studies to peruse....http://paleohacks.com/questions/20017/gluten-risks-for-non-celiac-folks#axzz20XUIbj4b

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3 Answers


on July 12, 2012
at 03:07 PM

Systemic autoimmune disorders in Celiac disease: The role of gluten as a trigger of autoimmunity.



on July 12, 2012
at 02:43 PM

A few (hopefully) helpful articles:

Type 1 diabetes (autoimmunity) and gut permeability: http://www.ncbi.nlm.nih.gov/pubmed/19122519

Type 1 diabetes and use of a gluten-free diet: http://www.ncbi.nlm.nih.gov/pubmed/22729336 (no medical recommendation given or intended)

Environmental triggers of T1D: http://www.ncbi.nlm.nih.gov/pubmed/22762021

Of course I could be just cherry-picking.....



on July 12, 2012
at 02:22 PM

This might not be exactly what you're looking for, but it's a start. Explains very well the mechanism of dietary triggers, the peptide/amino acid sequences that resemble human tissue, and leaky gut. Great diagrams to illustrate the concepts.

I used it for a paper on how a reduced grain lectin diet would be therapeutic for rheumatoid arthritis. The mechanism at work here in RA is pretty much the same one for any AI condition, I think.

Lectins & RA

Okay, looks like that link might not work so well...

Try this one and just click on "View PDF"

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