10

votes

The Apo-E4 Gene And High Animal Fat Diet

Answered on September 12, 2014
Created January 20, 2013 at 12:54 PM

On Jimmy Moore's Ask the Low Carb experts, he had Dr. Steven Gundry on and he said something I've never heard or come across before. He said people with the APO-E4 gene, which is 20% of the population, that a diet high in animal fat is damaging for these people.

I was wondering if anyone in the Bulletproof Community ever heard of this and agree? Also, does anyone know a cheaper source to get the test? The cheapest I could find is $399.00.

http://www.accesalab...CFQUFnQodhxQA7g

3d58b5fb4f9780e2f47d4dcc53338a5a

(2771)

on April 18, 2013
at 07:43 PM

I think it needs a more "layman" explanation than you gave. I've done a lot of reading and I'm not sure what you mean by "AD" results, and I'm not sure what you mean by "you NEVER get." because it's an incomplete sentence, so I'm not sure if you're referring to electron flow, or increasing or decreasing cholesterol or what. I think I get what you're saying about electron flow, but most people don't know anything about it, and those that might know a little (like me) may not know how to do it. Can you post a more detailed "common man" explanation? Mitochondrial activity is a good subject.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on February 03, 2013
at 02:39 PM

You believe it is incorrect......but it is not. AD is a disease of poor energy dynamics in the brain......and I am an expert in this. It is time for you to step your game up in this area.

E253f8ac1d139bf4d0bfb44debd1db21

on February 02, 2013
at 11:41 PM

That statement is as cryptic to most people as it is poorly written as it is factually wrong. Why would a person with your education and experience choose to disseminate information in this way?

6120c989fd5b69f42a0834b69b87955b

(24553)

on January 21, 2013
at 08:36 AM

If you use the search function on here for ApoE4 there were some good discussions about this a while back.

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7 Answers

10
Cbdc8318738324492f2d5918868ce4c9

(1211)

on January 20, 2013
at 01:59 PM

You can test for it at 23andme.com for $99, includes entire genome, not just ApoE gene.

It's specifically the E3/E4, E4/E4 alleles of the ApoE gene that are hyper-responders to dietary fat (25% of the population).

Here's some additional info to consider:
http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19

Warning: keep in mind ApoE4 is strongly associated with Alzheimer???s disease and some might find it unsettling and stressful to know, while others might find in empowering. 23andme will also provide other health risk factors associated with your genome.

4
5dd50f78f47b8848d93724d6eb38d4c1

on January 21, 2013
at 07:06 AM

It wouldn't be suprising. That would probably account for the posts you see asking "why is my ldl 220 and my total cholesterol over 300". Yet you see others eat the same diet and maintain a total cholesterol under 200.

2
874ff271ca3379984344d5f9f760fec3

on January 21, 2013
at 10:52 AM

"animal fat is damaging for these people" is an ignorant over-generalization that will only contribute to uniformed knee-jerk reactions. Gundry probably qualified that statement with context. Most people with APOE4 allele's digest, absorb, and retain all fats much BETTER than the "newer" /3's. This does require different eating habits to stay healthy for the long haul. Avoiding animal fat makes you unhealthy. Over eating animal fat OR protein makes you really unhealthy.

0
3d58b5fb4f9780e2f47d4dcc53338a5a

(2771)

on April 18, 2013
at 07:50 PM

The main problem with this is the assumption that the high cholesterol is damaging. High or low cholesterol in the blood isn't an indication of artery blockage or damage or anything else.

I think I would not worry too much about getting genetically tested and go for a heart scan instead. A lot of hospitals have a mobile van that goes out and does a series of tests, like an EKG and ultrasound of the heart and abdominal valves and such to see if they're blocked and flowing right. It cost me about $175 to do it, and it took a month and a half to get the results back, but a clean bill of health and no blockage let me know that my cholesterol numbers didn't mean anything in relation to my heart healthiness.

I have heard some people with really high cholesterol react to dairy more than other foods. My plan this month is to get a cholesterol check, and then go completely dairy free for a month and try again to see if that really does impact me.

If you have high cholesterol and are worried about it, then do a before and after experiment like what I'm going to do. If cutting out animal fats makes a difference, then you don't need a test. You'll then need to figure out if you need to make any changes.

I want to know about dairy in my diet so I know what to give up to lower my cholesterol in case I need to re-apply for insurance and I need to match the metrics of what they think is "normal."

0
6120c989fd5b69f42a0834b69b87955b

(24553)

on April 18, 2013
at 06:43 PM

This is a very interesting article I read yesterday about why a high fat diet might be an imperative rather than a detriment to prevent Alzheimer's in people with the ApoE4 allele because they have trouble transporting cholesterol into the cerebrospinal fluid, and a decline in cholesterol in the brain is apparently seen across the board in Alzheimer's cases. Also talks about why statins often used to reduce cholesterol in this particular population prone to high cholesterol can often make things much worse, it is not an accident that they have/produce more serum cholesterol, it is a byproduct of their body's trying to keep house. In addition to needlessly and potentially harmfully reducing cholesterol the statins cripple the part of the liver that synthesizes Co Q 10, leading to oxidative damage in the brain on top of starving it of cholesterol.

http://people.csail.mit.edu/seneff/alzheimers_statins.html

0
E1350fcfc41f52e78ba53b517d8100ff

(0)

on February 02, 2013
at 05:11 PM

@Helpberman - he didn't actually qualify it much. I was struck by it, too. My recollection is that he said people with what he called apoe3-3 and apoe4-3 both had problems with animal fats in particular and should stick with coconut, avocado and fish oil.

0
Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on January 21, 2013
at 09:23 PM

It is pretty easy to get around that defect......just got to increase electron flow in your mitochondrial membrane......for those who dont AD results. If you do you NEVER get. Pretty simple.

E253f8ac1d139bf4d0bfb44debd1db21

on February 02, 2013
at 11:41 PM

That statement is as cryptic to most people as it is poorly written as it is factually wrong. Why would a person with your education and experience choose to disseminate information in this way?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on February 03, 2013
at 02:39 PM

You believe it is incorrect......but it is not. AD is a disease of poor energy dynamics in the brain......and I am an expert in this. It is time for you to step your game up in this area.

3d58b5fb4f9780e2f47d4dcc53338a5a

(2771)

on April 18, 2013
at 07:43 PM

I think it needs a more "layman" explanation than you gave. I've done a lot of reading and I'm not sure what you mean by "AD" results, and I'm not sure what you mean by "you NEVER get." because it's an incomplete sentence, so I'm not sure if you're referring to electron flow, or increasing or decreasing cholesterol or what. I think I get what you're saying about electron flow, but most people don't know anything about it, and those that might know a little (like me) may not know how to do it. Can you post a more detailed "common man" explanation? Mitochondrial activity is a good subject.

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