On Jimmy Moore's Ask the Low Carb experts, he had Dr. Steven Gundry on and he said something I've never heard or come across before. He said people with the APO-E4 gene, which is 20% of the population, that a diet high in animal fat is damaging for these people.
I was wondering if anyone in the Bulletproof Community ever heard of this and agree? Also, does anyone know a cheaper source to get the test? The cheapest I could find is $399.00.
asked byHraz (100)
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on January 20, 2013
at 01:59 PM
You can test for it at 23andme.com for $99, includes entire genome, not just ApoE gene.
It's specifically the E3/E4, E4/E4 alleles of the ApoE gene that are hyper-responders to dietary fat (25% of the population).
Here's some additional info to consider:
Warning: keep in mind ApoE4 is strongly associated with Alzheimer???s disease and some might find it unsettling and stressful to know, while others might find in empowering. 23andme will also provide other health risk factors associated with your genome.
on January 21, 2013
at 07:06 AM
It wouldn't be suprising. That would probably account for the posts you see asking "why is my ldl 220 and my total cholesterol over 300". Yet you see others eat the same diet and maintain a total cholesterol under 200.
on January 21, 2013
at 10:52 AM
"animal fat is damaging for these people" is an ignorant over-generalization that will only contribute to uniformed knee-jerk reactions. Gundry probably qualified that statement with context. Most people with APOE4 allele's digest, absorb, and retain all fats much BETTER than the "newer" /3's. This does require different eating habits to stay healthy for the long haul. Avoiding animal fat makes you unhealthy. Over eating animal fat OR protein makes you really unhealthy.
on April 18, 2013
at 07:50 PM
The main problem with this is the assumption that the high cholesterol is damaging. High or low cholesterol in the blood isn't an indication of artery blockage or damage or anything else.
I think I would not worry too much about getting genetically tested and go for a heart scan instead. A lot of hospitals have a mobile van that goes out and does a series of tests, like an EKG and ultrasound of the heart and abdominal valves and such to see if they're blocked and flowing right. It cost me about $175 to do it, and it took a month and a half to get the results back, but a clean bill of health and no blockage let me know that my cholesterol numbers didn't mean anything in relation to my heart healthiness.
I have heard some people with really high cholesterol react to dairy more than other foods. My plan this month is to get a cholesterol check, and then go completely dairy free for a month and try again to see if that really does impact me.
If you have high cholesterol and are worried about it, then do a before and after experiment like what I'm going to do. If cutting out animal fats makes a difference, then you don't need a test. You'll then need to figure out if you need to make any changes.
I want to know about dairy in my diet so I know what to give up to lower my cholesterol in case I need to re-apply for insurance and I need to match the metrics of what they think is "normal."
on April 18, 2013
at 06:43 PM
This is a very interesting article I read yesterday about why a high fat diet might be an imperative rather than a detriment to prevent Alzheimer's in people with the ApoE4 allele because they have trouble transporting cholesterol into the cerebrospinal fluid, and a decline in cholesterol in the brain is apparently seen across the board in Alzheimer's cases. Also talks about why statins often used to reduce cholesterol in this particular population prone to high cholesterol can often make things much worse, it is not an accident that they have/produce more serum cholesterol, it is a byproduct of their body's trying to keep house. In addition to needlessly and potentially harmfully reducing cholesterol the statins cripple the part of the liver that synthesizes Co Q 10, leading to oxidative damage in the brain on top of starving it of cholesterol.
on February 02, 2013
at 05:11 PM
@Helpberman - he didn't actually qualify it much. I was struck by it, too. My recollection is that he said people with what he called apoe3-3 and apoe4-3 both had problems with animal fats in particular and should stick with coconut, avocado and fish oil.