1

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proinflammatory cytokines and acne

Answered on August 19, 2014
Created May 02, 2011 at 12:18 AM

I've been reading more of Dr. Cordain's theory of diet and acne. I follow a strict paleo diet, but still breakout from time to time. I take some GLA every day (16mg), but this hasn't helped. I've been hoping he will appear on the paleo solution to discuss acne with Robb Wolf, but I heard he has been super busy.

Do you think an immune modulator like EpiCor might help stop the excess pro-inflammatory response from cytokines? I know lactoferrin is another immune modulator which is proven for acne.

All I could dig up is this article:

http://www.embriahealth.com/upload/pdf/EpiCor%20Science%20-%20Effect%20of%20EpiCor%20Treatment%20on%20Type%20II%20Collagen-Induced%20Arthritis%20in%20Mice_9.2010.pdf

Since I am strict paleo, no nuts, low PUFA, good omega 6:3 ratio, lots of fermented foods and probiotics, barely any fruit, what could be causing these breakouts?

The only thing that has changed is that my Vitamin D levels have recently gotten much higher due to daily sun exposure (30-40 minutes a day).

My levels are around 90-100ng/ml

Can this be causing my immune response to go hyper reactive, leading to breakouts?

6e01c5e248d6a30bb7cb07d536aaf5b6

(193)

on May 03, 2011
at 04:55 AM

Really it's not called synthetic? I just remember the people's chemist calling supplemental D3 "synthetic" http://www.prweb.com/releases/The_Peoples_Chemist/Vitamin_D/prweb4847344.htm I was scared off from vitamin D supplements after listening to a podcast with Kurt Harris and Chris Kresser. Seems like FCLO is the way to go when sunshine isn't an option.

Eecc48184707bc26bce631485b5b7e34

(4764)

on May 02, 2011
at 09:10 PM

Cococnut oil as a topical doesn't work for me (oddly drying for my skin) but because it has such a low melting point, you should have no trouble using it (should you be so inclined) by simply scraping/scooping 1/8 or so tsp into your hand and rubbing it between your palms. It will melt instantly.

Eecc48184707bc26bce631485b5b7e34

(4764)

on May 02, 2011
at 09:08 PM

Stopping your supplemental D would be appropriate at this point. Currently, no D3 is synthetic. It's all either from fish liver or lanolin. Keep in mind that a year, in the scheme of things, is not that long in terms of having nutritional deficiencies pop up, or the opposite case of seeing benefits from improved nutritional sufficiency or depending on age and sex, the possibility that hormonal shifts are occuring and that those may require some tweaks in nutrition.

6e01c5e248d6a30bb7cb07d536aaf5b6

(193)

on May 02, 2011
at 04:17 AM

thanks Katherine, no synthetic vitamin D, just daily mid-day sun exposure for 30 minutes, i am light skinned, also taking some BLUE ICE Royal Butter Oil / Fermented Cod Liver Oil Blend as recommended by the healthy skeptic for vitamin A, K, D, etc... i do take optizinc 30mg daily, and have been taking this for the past year, but breakouts come and go in a seemingly random pattern. GLA comes from Spirulina, not evening primrose or borage oil. i'll definitely look into the marrow, broth ideas, just not sure where this would come from if my diet has been roughly consistent over the past year

6e01c5e248d6a30bb7cb07d536aaf5b6

(193)

on May 02, 2011
at 04:16 AM

never thought about using extra virgin coconut oil on my face as a topical, it is solid at room temp so this could be a pain and not very practical for daytime use, has anyone seen success with this? acne.org reviews are mixed.

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on May 02, 2011
at 02:55 AM

Zinc is an excellent rec. Plus one

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on May 02, 2011
at 02:55 AM

Sebum is loaded with MCT.....I would use coconut oil topically to help and make sure your D levels are higher than normal ranges

667f6c030b0245d71d8ef50c72b097dc

(15976)

on May 02, 2011
at 01:44 AM

I'm stuck too. You're diet sounds spot on. what I'm currently trying is Wolf's autoimmune protocol to deal with any inflammation that I may still have. Essentially it's strict paleo without nightshades and eggs.

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2 Answers

2
Eecc48184707bc26bce631485b5b7e34

on May 02, 2011
at 12:33 AM

I'd stop the GLA and have a closer look at zinc, Vitamin A, Vitamin D (are you supplementing as well as getting sun? if so, stop the supplements), Vitamin K, selenium, probiotics etc.

It appears that 25OHD levels of >65 ng/mL are not biologically appropriate. While they are possible to obtain just from sun, it's very very difficult to do so and your levels are pretty much impossible (wihtout D supplementation) unless quite fair and getting full day unprotected exposure indicating a lack of biological appropriateness.

There is some good info on zinc and acne (pubmed).

Also consider the inflammatory nature of significant tryptophan and methionine consumption. Consider shifting protein consumption toward more organ meat (not just liver but also sweetbreads, brain etc), marrow, broth (gelatinous proteins) and less muscle meat.

Ed71ab1c75c6a9bd217a599db0a3e117

(25482)

on May 02, 2011
at 02:55 AM

Zinc is an excellent rec. Plus one

Eecc48184707bc26bce631485b5b7e34

(4764)

on May 02, 2011
at 09:08 PM

Stopping your supplemental D would be appropriate at this point. Currently, no D3 is synthetic. It's all either from fish liver or lanolin. Keep in mind that a year, in the scheme of things, is not that long in terms of having nutritional deficiencies pop up, or the opposite case of seeing benefits from improved nutritional sufficiency or depending on age and sex, the possibility that hormonal shifts are occuring and that those may require some tweaks in nutrition.

6e01c5e248d6a30bb7cb07d536aaf5b6

(193)

on May 02, 2011
at 04:17 AM

thanks Katherine, no synthetic vitamin D, just daily mid-day sun exposure for 30 minutes, i am light skinned, also taking some BLUE ICE Royal Butter Oil / Fermented Cod Liver Oil Blend as recommended by the healthy skeptic for vitamin A, K, D, etc... i do take optizinc 30mg daily, and have been taking this for the past year, but breakouts come and go in a seemingly random pattern. GLA comes from Spirulina, not evening primrose or borage oil. i'll definitely look into the marrow, broth ideas, just not sure where this would come from if my diet has been roughly consistent over the past year

6e01c5e248d6a30bb7cb07d536aaf5b6

(193)

on May 03, 2011
at 04:55 AM

Really it's not called synthetic? I just remember the people's chemist calling supplemental D3 "synthetic" http://www.prweb.com/releases/The_Peoples_Chemist/Vitamin_D/prweb4847344.htm I was scared off from vitamin D supplements after listening to a podcast with Kurt Harris and Chris Kresser. Seems like FCLO is the way to go when sunshine isn't an option.

0
A0b8c4cc369f93ee987ce15b1bf323fe

on May 02, 2011
at 12:58 PM

In the past, someone once posted about DHA as a potential cause for acne: http://paleohacks.com/questions/23929/dha-causing-acne#axzz1LCLnf0d7

Maybe your supplementation is an aggravating factor? This does seem counter-intuitive, though.

What about your stress levels? Do you do heavy lifting? Cordain also discusses the role of IGF-1 in inflammatory acne, which I've read is increased by heaving lifting.

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